ANCA-associated systemic vasculitis: Aspects of diagnosis


DOI: https://dx.doi.org/10.18565/therapy.2024.1.126-136

Beketova T.V.

1) Central Clinical Hospital with Polyclinic of the Administration of the President of the Russian Federation, Moscow; 2) V.A. Nasonova Research Institute of Rheumatology, Moscow; 3) Moscow Polytechnic University
Abstract. Systemic vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA-SV) are among the rare rheumatological diseases, the importance of early detection of which is due to their poor prognosis. Crucial importance in ANCA-SV diagnosis has a detailed clinical analysis of the course of the disease and a detailed examination of patients with identification of pathognomonic signs, including asymptomatic ones. The article discusses clinical peculiarities of various variants of ANCA-SV, including granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis, illustrated by our own clinical observations. New classification criteria for this group of diseases, proposed by international experts in 2022, are discussed. Taking into account the multi-organ nature of ANCA-SV, presented data may be useful to a wide range of specialists.
Keywords: classification criteria for systemic vasculitis, antineutrophil cytoplasmic antibodies, eosinophilic granulomatosis with polyangiitis, granulomatosis with polyangiitis, microscopic polyangiitis, systemic vasculitis
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About the Autors

Tatyana V. Beketova, MD, Dr. Sci. (Medicine), rheumatologist, head of the Department of rheumatology, Central Clinical Hospital with Polyclinic of the Administration of the President of the Russian Federation, leading researcher at the Department of systemic sclerosis, V.A. Nasonova Research Institute of Rheumatology, professor of Moscow Polytechnic University. Address: 121359, Moscow, 15 Marshala Timoshenko St.
E-mail: doc@tvbek.ru
ORCID: https://orcid.org/0000-0003-2641-9785


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