Chemopreventive and anti-tumor potential of ademetionine in case of chronic hepatic disorders


DOI: https://dx.doi.org/10.18565/therapy.2024.3.125-136

Prikhodko V.A., Okovityi S.V.

1) Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Healthcare of Russia; 2) Saint Petersburg State University
Abstract. Hepatocellular cancer (HCC) is a primary hepatic tumor starting from hepatocytes, is characterized by high aggressiveness and conditionally unfavorable prognosis, which makes the problem of its chemoprevention urgent. Despite the numerous drugs considered as chemopreventive agents, their use in clinical practice is limited by the small volume and unsystematic nature of evidence of their efficacy and safety. Current work considers well known metabolic and epigenetic mechanisms of action of ademetionine (S-adenosyl-L-methionine), which are laying in the basis of its chemopreventive and antitumor activity against HCC.

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About the Autors


Veronika A. Prikhodko, PhD (Biology), senior lecturer of the Department of pharmacology and clinical pharmacology, Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 14, lit. A Professora Popova St.
E-mail: veronika.prihodko@pharminnotech.com
ORCID: https://orcid.org/0000-0002-4690-1811
Sergey V. Okovityi, MD, Dr. Sci. (Medicine), professor, head of the Department of pharmacology and clinical pharmacology of the Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Healthcare of Russia, professor of the scientific, clinical and educational center for gastroenterology and hepatology, Saint Petersburg State University. Address: 197022, Saint Petersburg, 14, lit. A Professora Popova St.
E-mail: sergey.okovity@pharminnotech.com
ORCID: https://orcid.org/0000-0003-4294-5531


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