Хемопревентивный и противоопухолевый потенциал адеметионина при хронических заболеваниях печени


DOI: https://dx.doi.org/10.18565/therapy.2024.3.125-136

В.А. Приходько, С.В. Оковитый

1) ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России; 2) ФГБОУ ВО «Санкт-Петербургский государственный университет»
Аннотация. Гепатоцеллюлярный рак (ГЦР) – первичная опухоль печени, происходящая из гепатоцитов, – характеризуется высокой агрессивностью и условно неблагоприятным прогнозом, что делает актуальной проблему ее хемопревенции. Несмотря на многочисленность средств, рассматриваемых в качестве хемопревентивных агентов, их применение в клинической практике ограничено малым объемом и несистематическим характером доказательств их эффективности и безопасности. В настоящей работе рассмотрены известные метаболические и эпигенетические механизмы действия адеметионина (S-аденозил-L-метионина), лежащие в основе его хемопревентивной и противоопухолевой активности в отношении ГЦР.

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Об авторах / Для корреспонденции


Вероника Александровна Приходько, к. биол. н., старший преподаватель кафедры фармакологии и клинической фармакологии ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России. Адрес: 197022, г. Санкт-Петербург, ул. Профессора Попова, д. 14, лит. А.
E-mail: veronika.prihodko@pharminnotech.com
ORCID: https://orcid.org/0000-0002-4690-1811
Сергей Владимирович Оковитый, д. м. н., профессор, заведующий кафедрой фармакологии и клинической фармакологии ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России, профессор Научно-клинического и образовательного центра гастроэнтерологии и гепатологии ФГБОУ ВО «Санкт-Петербургский государственный университет». Адрес: 197022, г. Санкт-Петербург, ул. Профессора Попова, д. 14, лит. А.
E-mail: sergey.okovity@pharminnotech.com
ORCID: https://orcid.org/0000-0003-4294-5531


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