Additional diagnostic markers of comorbid version of vibration disease combined with arterial hypertension


DOI: https://dx.doi.org/10.18565/therapy.2024.5.68-78

Gorbunova A.M., Gerasimenko O.N., Shpagin I.S., Belyaeva T.M., Tolmacheva A.A., Maksimov V.N.

1) Novosibirsk State Medical University of the Ministry of Healthcare of Russia; 2) Semey Medical University of the Ministry of Healthcare of the Republic of Kazakhstan, Semey; 3) Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center “Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Sciences”, Novosibirsk
Abstract. Vibration disease (VD) in combination with arterial hypertension (AH) today is one of the leading problems in therapeutic clinical practice and occupational medicine.
The aim: to study additional clinical-functional, nutritional-metabolic and molecular-genetic diagnostic markers of the comorbid variant of VD in combination with arterial hypertension.
Material and methods. A single-center, open, non-randomized, cross-sectional study was performed. All the participants were divided into four groups: 1st – patients with isolated VD (n = 104); 2nd – patients with arterial hypertension (n = 107); 3rg group – patients with comorbid model of VD + arterial hypertension (n = 101); 4th (control group) – conditionally healthy individuals working at the same enterprise without contact with vibration and not suffering from hypertension (n = 119).
Results. The following most significant changes were revealed in VB + AH group: an increase in the frequency of general and specific complaints, high body mass index values corresponding to obesity of the 2nd and 3rd degrees, decrease in active cell mass and phase angle, decrease of adipocytokine profile indexes, lower vitamin D levels comparatively to other groups (all p < 0.0001). It was found that the molecular picture of inflammation in case of VD combined with arterial hypertension differs significantly from that in case of isolated VD and case of isolated hypertension. When studying a group of patients with VD + arterial hypertension, it was found that the increased frequency of T/T rs4880 genotype of superoxide dismutase SOD2 gene appears to be a characteristic of oxidative stress.
Conclusion. Formation of VD, combined with arterial hypertension, occurs secondary to nutritional and metabolic disorders in association with clinical and functional parameters, changes in adipocytokine status, systemic inflammation, vitamin D levels, endothelial dysfunction and oxidative stress, as well as an increased frequency of detection of the polymorphic variant of T/T locus Ala 16 Val (rs4880) of the MnSOD (superoxide dismutase) gene.
Keywords: anthropometric indicators, vibration disease, nutritional status, comorbidity, gene polymorphism, arterial hypertension
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About the Autors

Alena M. Gorbunova, MD, postgraduate student, assistant, head of the educational unit of the Department of faculty therapy named after professor G.D. Zalessky of the Faculty of general medicine, Novosibirsk State Medical University of the Ministry of Healthcare of Russia. Address: 630005, Novosibirsk, 71 Demyana Bednogo St.
E-mail: belyaeva-alena@list.ru
ORCID: https://orcid.org/0000-0002-1593-3984
Oksana N. Gerasimenko, MD, Dr. Sci. (Medicine), professor, head of the Department of faculty therapy named after professor G.D. Zalessky of the Faculty of general medicine, Novosibirsk State Medical University of the Ministry of Healthcare of Russia. Address: 630005, Novosibirsk, 71 Demyana Bednogo St.
E-mail: profgerasimenko@inbox.ru
ORCID: https://orcid.org/0000-0002-9742-0479
Ilya S. Shpagin, MD, Dr. Sci. (Medicine), associate professor of the Department of hospital therapy and medical rehabilitation of the Faculty of pediatrics, Novosibirsk State Medical University of the Ministry of Healthcare of Russia. Address: 630051, Novosibirsk, 21 Polzunova St.
E-mail: Dr.ilya.shpagin@gmail.ru
ORCID: https://orcid.org/0000-0002-3109
Tatyana M. Belyaeva, MD, PhD (Medicine), associate professor of the Department of general medical practice, Semey Medical University of the Ministry of Healthcare of the Republic of Kazakhstan. Address: 071400, Republic of Kazakhstan, Semey, 103 Abaya St.
E-mail: btm56@rambler.ru
ORCID: https://orcid.org/0000-0002-2565-2393
Anastasia A. Tolmacheva, MD, PhD (Medicine), assistant at the Department of faculty therapy named after professor G.D. Zalessky of the Faculty of general medicine, Novosibirsk State Medical University of the Ministry of Healthcare of Russia. Address: 630005, Novosibirsk, 71 Demyana Bednogo St.
E-mail: tolmacheva_nastena@mail.ru
ORCID: https://orcid.org/0000-0003-1687-4100
Vladimir N. Maksimov, MD, Dr. Sci. (Medicine), professor, professor of the Department of medical genetics and medical biology, Novosibirsk State Medical University of the Ministry of Healthcare of Russia, head of the Department of molecular genetic research of therapeutic diseases of Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center “Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Sciences”. Address: 630089, Novosibirsk, 175/1 B. Bogatkova St.
E-mail: medik11@mail.ru
ORCID: https://orcid.org/0000-0002-7165-4496


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