Immunoglobulin E and malignant neoplasms


DOI: https://dx.doi.org/10.18565/therapy.2024.10.108-114

Radygina L.V.

All-Russian Institute of Scientific and Technical Information of the Russian Academy of Sciences, Moscow
Abstract. Immunoglobulin E (IgE) is usually associated with allergic and parasitic diseases. The aim of the review is to present the role of IgE in case of malignant neoplasms. The search for relevant literature was performed in PubMed, Scopus databases for 2020–2024. It was found that ultra-low IgE levels can serve as a new biomarker of cancer susceptibility. At the same time, high IgE levels can contribute to the pathogenesis of Kaposi’s sarcoma and are associated with poor overall survival in patients with acute myeloid leukemia. The article also discusses IgE-type multiple myeloma, shows correlation between IgE and allergic reactions to antitumor drugs, and highlights a new direction in the treatment of malignant neoplasms – IgE therapy.

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About the Autors


Lyubov V. Radygina, MD, researcher at the Department of scientific information “Life sciences”, All-Russian Institute of Scientific and Technical Information of the Russian Academy of Sciences. Address: 125315, Moscow, 20 Usievicha St.
E-mail: lubarаdygina@yandex.ru
ORCID: https://orcid.org/0000-0003-2853-770X


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