Новые возможности уратснижающей терапии у пациентов, страдающих подагрой


DOI: https://dx.doi.org/10.18565/therapy.2018.7-8.111-118

М.С. Петрова, М.М. Мусийчук, О.В. Инамова, В.И. Мазуров

1 Кафедра терапии и ревматологии им. Э.Э. Эйхвальда ФГОУ ВО «Северо-Западный государственный университет им. И.И. Мечникова», г. Санкт Петербург, Россия; 2 ГБУЗ СПб «Клиническая ревматологическая больница № 25», Санкт Петербург, Россия; 3 Городской клинический центр подагры, Санкт Петербург, Россия
Фебуксостат – недавно появившееся на российском фармацевтическом рынке противоподагрическое средство; оно представляет собой непуриновый, селективный ингибитор изоформ ксантиноксидоредуктазы (КОР), действие которого направлено на снижение уровня мочевой кислоты (МК) в сыворотке крови. Фармакокинетические свойства фебуксостата не зависят от почечного клиренса, что отличает его от аллопуринола и может служить преимуществом при лечении пациентов с хроническими заболеваниями почек. В целом ряде исследований проводится дальнейшая оценка безопасности фебуксостата в отношении сердечно-сосудистой системы, а также позитивного воздействия на сохранение функции почек. Фебуксостат более значимо подавляет КОР, чем аллопуринол, что подтверждается более частым достижением целевого уровня МК, особенно у пациентов с высокой концентрацией уратов в сыворотке крови. Немаловажно и то, что у пожилых пациентов не требуется коррекции дозы фебуксостата.
Ключевые слова: подагра, гиперурикемия, фебуксостат, аллопуринол, хронические заболевания почек, сердечно-сосудистые заболевания
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    • Об авторах / Для корреспонденции

    Марианна Семеновна Петрова, к.м.н., руководитель Городского клинического центра подагры, доцент кафедры терапии и ревматологии им. Э.Э. Эйхвальда ФГОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова». Адрес: 190068, Санкт Петербург, Большая Подъяческая, д. 30.
    Мария Меджидовна Мусийчук, врач-ревматолог ГБУЗ СПб «Клиническая ревматологическая больница № 25». Адрес: 190068, Санкт Петербург, Большая Подъяческая, д. 30.
    Оксана Владимировна Инамова, к.м.н., главный врач ГБУЗ СПб «Клиническая ревматологическая больница
    № 25». Адрес: 190068, Санкт Петербург, Большая Подъяческая, д. 30.
    Вадим Иванович Мазуров, д.м.н., профессор, академик РАН, завкафедрой терапии и ревматологии им. Э.Э. Эйхвальда ФГОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова», заслуженный деятель науки. Адрес: 191015, Санкт Петербург, ул. Кирочная, д. 41.

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