Применение ацетилсалициловой кислоты и ее комбинированных форм в реальной клинической практике

1. Fuste V, Sweeny JM. Aspirin: A historical and contemporary therapeutic overview. Circulation. 2011;123(7):768–78.

PMID: 21343593. https://doi.org/10.1161/circulationaha.110.963843

2. Desborough MJR., Keeling DM. The aspirin story – from willow to wonder drug. Br J Haematol. 2017;177(5):674–83.

PMID: 28106908. https://doi.org/10.1111/bjh.14520

3. Fijałkowski Ł, Skubiszewska M, Grześk G, Koech FK, Nowaczyk A. Acetylsalicylic acid-primus inter pares in pharmacology. Molecules. 2022;27(23):8412.

PMID: 36500502. PMCID: PMC9738180. https://doi.org/10.3390/molecules27238412

4. Collaborative overview of randomised trials of antiplatelet therapy – I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists’ Collaboration. BMJ. 1994;308(6921):81– 106. PMID: 8298418. PMCID: PMC2539220.

5. Kirchner VA, O’Farrell B, Imber C, McCormack L, Northup PG, Song G-W et al.; ERAS4OLT.org Working Group. What is the optimal management of thromboprophylaxis after liver transplantation regarding prevention of bleeding, hepatic artery, or portal vein thrombosis? A systematic review of the literature and expert panel recommendations. Clin Transplant. 2022;36(10):e14629.

PMID: 35240723. PMCID: PMC10078564. https://doi.org/10.1111/ctr.14629

6. Atallah A, Lecarpentier E, Goffinet F, Doret-Dion M, Gaucherand P, Tsatsaris V. Aspirin for prevention of preeclampsia. Drugs. 2017;77(17):1819–31.

PMID: 29039130. PMCID: PMC5681618. https://doi.org/10.1007/s40265-017-0823-0

7. Patrono C, Rodríguez LAG, Landolfi R, Baigent C. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med. 2005;353(22):2373–83.

PMID: 16319386. https://doi.org/10.1056/nejmra052717

8. Davì G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007;357(24):2482–94.

PMID: 18077812. https://doi.org/10.1056/nejmra071014

9. Patrono C, Ciabattoni G, Patrignani P, Pugliese F, Filabozzi P, Catella F et al. Clinical pharmacology of platelet cyclooxygenase inhibition. Circulation. 1985;72(6):1177–84.

PMID: 3933848. https://doi.org/10.1161/01.cir.72.6.1177

10. Patrignani P, Filabozzi P, Patrono C. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest. 1982;69(6):1366–72.

PMID: 7045161. PMCID: PMC370209. https://doi.org/10.1172/jci110576

11. Patrono C, Morais J, Baigent C, Collet J-P, Fitzgerald D, Halvorsen S et al. Antiplatelet agents for the treatment and prevention of coronary atherothrombosis. J Am Coll Cardiol. 2017;70(14):1760–76.

PMID: 28958334. https://doi.org/10.1016/j.jacc.2017.08.037

12. Patrignani P, Tacconelli S, Piazuelo E, Di Francesco L, Dovizio M, Sostres C et al. Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action. J Thromb Haemost. 2014;12(8):1320–30.

PMID: 24942808. https://doi.org/10.1111/jth.12637

13. Coxib and traditional NSAID Trialists’ (CNT) Collaboration; Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: Meta-analyses of individual participant data from randomised trials. Lancet. 2013;382(9894):769–79.

PMID: 23726390. PMCID: PMC3778977. https://doi.org/10.1016/S0140-6736(13)60900-9

14. Catella-Lawson F, Reilly MP, Kapoor SC, Cucchiara AJ, DeMarco S, Tournier B et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345(25):1809–17.

PMID: 11752357. https://doi.org/10.1056/nejmoa003199

15. Rocca B, Patrono C. Determinants of the interindividual variability in response to antiplatelet drugs. J Thromb Haemost. 2005;3(8):1597–1602.

PMID: 16102024. https://doi.org/10.1111/j.1538-7836.2005.01380.x

16. Rocca B, Fox KAA, Ajjan RA, Andreotti F, Baigent C, Collet J-P et al. Antithrombotic therapy and body mass: An expert position paper of the ESC Working Group on Thrombosis. Eur Heart J. 2018;39(19):1672–86.

PMID: 29509886. https://doi.org/10.1093/eurheartj/ehy066

17. Marquis-Gravel G, Stebbins A, Wruck LM, Roe MT, Effron MB, Hammill BG et al. Age and aspirin dosing in secondary prevention of atherosclerotic cardiovascular disease. J Am Heart Assoc. 2024;13(4):e026921.

PMID: 38348779. PMCID: PMC11010083. https://doi.org/10.1161/jaha.122.026921

18. Lanas A, Werz O, Mikhail E. Comparison of gastrointestinal adverse events between fast release tablets and regular acetylsalicylic acid (aspirin) galenics after short-term use: A meta-analysis of randomized clinical trials. Inflammopharmacology. 2023;31(5):2369–81.

PMID: 37603157. PMCID: PMC10518280. https://doi.org/10.1007/s10787-023-01264-3

19. Chesebro JH, Clements IP, Fuster V, Elveback LR, Smith HC, Bardsley WT et al. A platelet-inhibitor-drug trial in coronary-artery bypass operations: Benefit of perioperative dipyridamole and aspirin therapy on early postoperative vein-graft patency. N Engl J Med. 1982;307(2):73–78.

PMID: 7045659. https://doi.org/10.1056/nejm198207083070201

20. Burch JW, Stanford N, Majerus PW. Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest. 1978;61(2):314–19.

PMID: 413839. PMCID: PMC372541. https://doi.org/10.1172/jci108941

21. Pedersen AK, FitzGerald GA. Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. N Engl J Med. 1984;311(19):1206–11.

PMID: 6436696. https://doi.org/10.1056/nejm198411083111902

22. Giaretta A, Rocca B, Di Camillo B, Toffolo GM, Patrono C. In silico modeling of the antiplatelet pharmacodynamics of low-dose aspirin in health and disease. Clin Pharmacol Ther. 2017;102(5):823–31.

PMID: 28378909. https://doi.org/10.1002/cpt.694

23. Patrono C, Rocca B, De Stefano V. Platelet activation and inhibition in polycythemia vera and essential thrombocythemia. Blood. 2013;121(10):1701–11.

PMID: 23335367. https://doi.org/10.1182/blood-2012-10-429134

24. Cavalca V, Rocca B, Veglia F, Petrucci G, Porro B, Myasoedova V et al. On-pump cardiac surgery enhances platelet renewal and impairs aspirin pharmacodynamics: Effects of improved dosing regimens. Clin Pharmacol Ther. 2017;102(5):849–58.

PMID: 28379623. https://doi.org/10.1002/cpt.702

25. Pascale S, Petrucci G, Dragani A, Habib A, Zaccardi F, Pagliaccia F et al. Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target. Blood. 2012;119(15):3595–3603.

PMID: 22234683. https://doi.org/10.1182/blood-2011-06-359224

26. Krasinska B, Paluszkiewicz L, Miciak-Ławicka E, Krasinski M, Rzymski P, Tykarski A, Krasiński Z. The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients – a randomized, controlled trial. Eur J Clin Pharmacol. 2021;77(1):35–43.

PMID: 32959110. PMCID: PMC7782434. https://doi.org/10.1007/s00228-020-02997-8

27. Pareek M, Kristensen SD, Grove EL. Cardiovascular events after discontinuation of low-dose aspirin. J Thorac Dis. 2018;10(1):75–78.

PMID: 29600025. PMCID: PMC5863118. https://doi.org/10.21037/jtd.2017.12.48

28. Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL et al.; ESC Scientific Document Group. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J. 2016;37(29):2315–81.

PMID: 27222591. PMCID: PMC4986030. https://doi.org/10.1093/eurheartj/ehw106

29. Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324(7329):71–86.

PMID: 11786451. PMCID: PMC64503. https://doi.org/10.1136/bmj.324.7329.71

30. Jones WS, Mulder H, Wruck LM, Pencina MJ, Kripalani S, Muñoz D et al.; ADAPTABLE Team. Comparative effectiveness of aspirin dosing in cardiovascular disease. N Engl J Med. 2021;384(21):1981–90.

PMID: 33999548. PMCID: PMC9908069. https://doi.org/10.1056/nejmoa2102137

31. Lewis HD Jr, Davis JW, Archibald DG, Steinke WE, Smitherman TC, Doherty JE 3rd et al. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study. N Engl J Med. 1983;309(7):396–403.

PMID: 6135989. https://doi.org/10.1056/nejm198308183090703

32. Wallentin LC. Aspirin (75 mg/day) after an episode of unstable coronary artery disease: Long-term effects on the risk for myocardial infarction, occurrence of severe angina and the need for revascularization. Research Group on Instability in Coronary Artery Disease in Southeast Sweden. J Am Coll Cardiol. 1991;18(7):1587–93.

PMID: 1960301. https://doi.org/10.1016/0735-1097(91)90489-v

33. Cairns JA, Gent M, Singer J, Finnie KJ, Froggatt GM, Holder DA et al. Aspirin, sulfinpyrazone, or both in unstable angina. Results of a Canadian multicenter trial. N Engl J Med. 1985;313(22):1369–75.

PMID: 3903504. https://doi.org/10.1056/nejm198511283132201

34. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 1996;348(9038):1329–39.

PMID: 8918275. https://doi.org/10.1016/s0140-6736(96)09457-3

35. Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: A randomised trial. The SYMPHONY Investigators. Sibrafiban versus aspirin to yield maximum protection from ischemic heart events post-acute coronary syndromes. Lancet. 2000;355(9201):337–45. PMID: 10665552.

36. Bousser M-G, Amarenco P, Chamorro A, Fisher M, Ford I, Fox KM et al.; PERFORM Study Investigators. Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): A randomised, double-blind, parallel-group trial. Lancet. 2011;377(9782):2013–22.

PMID: 21616527. https://doi.org/10.1016/s0140-6736(11)60600-4

37. Johnston SC, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR et al.; SOCRATES Steering Committee and Investigators. Ticagrelor versus aspirin in acute stroke or transient ischemic attack. N Engl J Med. 2016;375(1):35–43.

PMID: 27160892. https://doi.org/10.1056/NEJMoa1603060

38. Vranckx P, Valgimigli M, Jüni P, Hamm C, Steg PG, Heg D et al.; GLOBAL LEADERS Investigators. Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: A multicentre, open-label, randomised superiority trial. Lancet. 2018;392(10151):940–49.

PMID: 30166073. https://doi.org/10.1016/S0140-6736(18)31858-0

39. Koo B-K, Kang J, Park KW, Rhee T-M, Yang H-M, Won K-B et al.; HOST-EXAM investigators. Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention (HOST-EXAM): An investigator-initiated, prospective, randomised, open-label, multicentre trial. Lancet, 2021;397(10293):2487–96.

PMID: 34010616. https://doi.org/10.1016/S0140-6736(21)01063-1

40. Chiarito M, Sanz-Sanchez J, Cannata F, Cao D, Sturla M, Panico C et al. Monotherapy with a P2Y12 inhibitor or aspirin for secondary prevention in patients with established atherosclerosis: A systematic review and meta-analysis. Lancet. 2020;395(10235):1487– 95.

PMID: 32386592. https://doi.org/10.1016/S0140-6736(20)30315-9

41. Gragnano F, Cao D, Pirondini L, Franzone A, Kim H-S, von Scheidt M et al.; PANTHER Collaboration. P2Y12 inhibitor or aspirin monotherapy for secondary prevention of coronary events. J Am Coll Cardiol. 2023;82(2):89–105.

PMID: 37407118. https://doi.org/10.1016/j.jacc.2023.04.051

42. Tantry US, Navarese EP, Bliden KP, Gurbel PA. Acetylsalicylic acid and clopidogrel hyporesponsiveness following acute coronary syndromes. Kardiol Pol. 2018;76(9):1312–19.

PMID: 30091133. https://doi.org/10.5603/kp.a2018.0159

43. Khalili M, Lepeytre F, Guertin JR, Goupil R, Troyanov S, Bouchard J, Madore F. Impact of updated recommendations on acetylsalicylic acid use for primary prevention of cardiovascular disease in Canada: A population-based survey. CMAJ Open. 2020;8(1):E41–E47.

PMID: 31992558. PMCID: PMC6996036. https://doi.org/10.9778/cmajo.20190105

44. Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ et al. 2019 ACC/AHA Guideline on the primary prevention of cardiovascular disease: A report of the American College of Cardiology / American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;140(11):e596–e646.

PMID: 30879355. PMCID: PMC7734661. https://doi.org/10.1161/cir.0000000000000678

45. Zheng SL, Roddick AJ. Association of aspirin use for primary prevention with cardiovascular events and bleeding events: A systematic review and meta-analysis. JAMA. 2019;321(3):277–87.

PMID: 30667501. PMCID: PMC6439678. https://doi.org/10.1001/jama.2018.20578

46. Rognvaldsson KG, Bjarnason A, Kristinsson K, Bragason HT, Erlendsdóttir H, Þorgeirsson G, Gottfreðsson M. Acetylsalicylic acid use is associated with improved survival in bacteremic pneumococcal pneumonia: A long-term nationwide study. J Intern Med. 2022;292(2):321–32.

PMID: 35315156. PMCID: PMC9543431. https://doi.org/10.1111/joim.13485

47. ASCEND Study Collaborative Group; Bowman L, Mafham M, Wallendszus K, Stevens W, Buck G, Barton J et al. Effects of aspirin for primary prevention in persons with diabetes mellitus. N Engl J Med. 2018;379(16):1529–39.

PMID: 30146931. https://doi.org/10.1056/nejmoa1804988

48. Wein T, Lindsay MP, Gladstone DJ, Poppe A, Bell A, Casaubon LK et al.; Heart and Stroke Foundation of Canada in collaboration with the Canadian Stroke Consortium. Canadian Stroke best practice recommendations, seventh edition: Acetylsalicylic acid for prevention of vascular events. CMAJ. 2020;192(12):E302–E311.

PMID: 32392513. PMCID: PMC7101172. https://doi.org/10.1503/cmaj.191599

49. Berger JS, Brown DL, Becker RC. Low-dose aspirin in patients with stable cardiovascular disease: A meta-analysis. Am J Med. 2008;121(1):43–49.

PMID: 18187072. https://doi.org/10.1016/j.amjmed.2007.10.002

50. Patrono C, Rocca B. Nonsteroidal antiinflammatory drugs: Past, present and future. Pharmacol Res. 2009;59(5):285–89.

PMID: 19416627. https://doi.org/10.1016/j.phrs.2009.01.011

51. Gawaz M, Vogel S. Platelets in tissue repair: Control of apoptosis and interactions with regenerative cells. Blood. 2013;122(15):2550–54.

PMID: 23963043. https://doi.org/10.1182/blood-2013-05-468694

52. Kontoghiorghes GJ. The puzzle of aspirin and iron deficiency: The vital missing link of the iron-chelating metabolites. Int J Mol Sci. 2024;25(10):5150.

PMID: 38791185. PMCID: PMC11121054. https://doi.org/10.3390/ijms25105150

53. CURRENT-OASIS 7 Investigators; Mehta SR, Bassand J-P, Chrolavicius S, Diaz R, Eikelboom JW, Fox KAA et al. Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N Engl J Med. 2010;363(10):930–42.

PMID: 20818903. https://doi.org/10.1056/nejmoa0909475

54. Miilunpohja S, Jyrkkä J, Kärkkäinen JM, Kastarinen H, Heikkinen M, Paajanen H et al. Discontinuing low-dose acetylsalicylic acid after gastrointestinal bleeding is associated with increased mortality. Scand J Gastroenterol. 2022;57(5):618–24.

PMID: 35041575. https://doi.org/10.1080/00365521.2022.2026461

55. Scally B, Emberson JR, Spata E, Reith C, Davies K, Halls H et al. Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: A meta-analysis of randomised trials. Lancet Gastroenterol Hepatol. 2018;3(4):231–41.

PMID: 29475806. PMCID: PMC5842491. https://doi.org/10.1016/S2468-1253(18)30037-2

56. Hawkey C, Avery A, Coupland CAC, Crooks C, Dumbleton J, Hobbs FDR et al.; HEAT Trialists. Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): A randomised, double-blind, placebo-controlled trial. Lancet. 2022;400(10363):1597–1606.

PMID: 36335970. https://doi.org/10.1016/S0140-6736(22)01843-8

57. Yoskovitz GS, Yoskovitz MS, Haim-Pinhas H, Saban M, Pereg D, Wand O et al. Risk factors for major bleeding among patients with chronic kidney disease treated with acetylsalicylic acid. Kidney Blood Press Res. 2024;49(1):1033–40.

PMID: 39527927. https://doi.org/10.1159/000542500