Systemic scleroderma and chronic kidney disease


A.Yu. Zakharova , A.V. Gordeev, Z.Yu. Mutovina, L.P. Ananyeva, Ye.A. Galushko

1 V.A. Nasonova Research Institute of Rheumatology, Moscow 2 Educational scientific medical center, Department of therapy, cardiology and functional diagnostics with a course of nephrology and rheumatology, Moscow
The article considers the variants of chronic kidney disease (CKD) in systemic scleroderma (SSD). Following manifestations of subclinical CKD in this disease should be noted: 1) an isolated decrease in glomerular filtration rate; 2) an increase in the renal resistivity index; 3) decreased renal functional reserve. 15-year survival rate in SSD patients without CKD is 72%, in the presence of CKD – not more than 13%. The importance of the phenomenon of vascular endothelial dysfunction in the pathogenesis of CKD in SSD is discussed in detail. It is emphasized that a variety of drugs used in this disease, in the first place, D-penicillamine, can contribute to the development of CKD in the SSD.
Keywords: drug-induced nephropathy, chronic endothelial dysfunction, systemic scleroderma, chronic kidney disease
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About the Autors

Anastasiya Yu. Zakharova , junior researcher, V.A. Nasonova Research Institute of Rheumatology. Address: 115522, Moscow, 34a Kashyrskoe shosse. Tel.: +74996189092

Andrey V. Gordeev, MD, professor, senior researcher, V.A. Nasonova Research Institute of Rheumatology. Address: 115522, Moscow, 34a Kashyrskoe shosse. Tel.: +74996189092. E-mail: andrewgordeew@gmail.com

Lidiya P. Ananyeva, MD, professor, head of Laboratory of microcirculation and inflammation, V.A. Nasonova Research Institute of Rheumatology. Address: 115522, Moscow, 34a Kashyrskoe shosse. Tel.: +74996189092. E-mail: lpana@yandex.ru

Zinaida Yu. Mutovina, PhD, associate professor of Department of therapy, cardiology and functional diagnostics with a course of nephrology and rheumatology, Educational scientific medical center. Address: 121359, Moscow, 19, bld. 1A Marshala Timoshenko St. Tel.: +74995300517

Yelena A. Galushko, MD, head of Educational-methodical department with the information technology center, V.A. Nasonova Research Institute of Rheumatology. Address: 115522, Moscow, 34a Kashyrskoe shosse.
Tel.: +74996189092


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