Possibilities of fixed combination of nitrendipine and enalapril in the treatment of arterial hypertension


G.A. Batishcheva, O.A. Mubarakshina, M.N. Somova, A.S. Yevstigneeva

N.N. Burdenko Voronezh State Medical University, Department of clinical pharmacology, Voronezh
Modern approaches to the therapy of arterial hypertension involve the use of a combination of antihypertensive drugs at the beginning of treatment. The combination of an angiotensin-converting enzyme inhibitor with a long-acting calcium channel blocker presents an alternative to widely used combinations with diuretics. According to the results of clinical studies, combination of enalapril with nitrendipine has proved to be a highly effective and safe, including in elderly patients. The combined use of these drugs increases the antihypertensive effect, while reducing the severity of the side effects of each component.
Keywords: nitrendipine, fixed combinations, enalapril, antihypertensive therapy, arterial hypertension
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About the Autors

Galina A. Batishcheva, MD, professor, head of the Department of clinical pharmacology, N.N. Burdenko Voronezh State medical university. Address: 394036, Voronezh, 10 Studencheskaya St. Tel.: +74732371011

Olga A. Mubarakshina, PhD, assistant of the Department of clinical pharmacology, N.N. Burdenko Voronezh State medical university. Address: 394036, Voronezh, 10 Studencheskaya St. Tel.: +74732371011.
E-mail: mubarakshina@mail.ru

Marina N. Somova, PhD, associate professor of the Department of clinical pharmacology, N.N. Burdenko Voronezh State medical university. Address: 394036, Voronezh, 10 Studencheskaya St. Tel.: +74732371011. E-mail: somova_marina@inbox.ru

Anastasiya S. Yevstigneeva, clinical intern of the Department of clinical pharmacology, N.N. Burdenko Voronezh State medical university. Address: 394036, Voronezh, 10 Studencheskaya St. Tel.: +74732371011.


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