Cerebrovascular disease: Pharmacological properties and efficacy of dipiridamol as a medicament with pleiotropic action mechanism


Cheltsov V.V., Martynov A.I.

1 Federal State Autonomous Educational Institution «People’s Friendship University of Russia», Medical institute, Moscow; 2 Federal State Budgetary Educational Institution of Higher Education «Moscow state university of medicine and dentistry» of the Ministry of Helthcare of Russia, Moscow
Main clinical-pharmacological effects of dipiridamol action are considered in the context of its use in case of cerebrovascular disease. The vasodilatating effect of the medicine, antioxidative effect and ability to improve tissue perfusion are accentuated. The results of experimental and clinical research work reflecting efficacy and safety of dipiridamol are introduced. Pleiotropic action mechanism of the medicament whicht makes it possible to have a complex influence at pathogenetic factors of cerebrovascular disease is noted.
Keywords: Keу words: dipyridamole, antiaggregants, pleiotropic effects
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    • About the Autors

    Victor V. Cheltsov, MD, professor of the Department of general and clinical pharmacology, Мedical Institute of the Russian people’s friendship University. Address: 117198, Moscow, Miklukho-Maklaya str. 10, buil. 1 Tel.:+74957873803. E-mail.:vcheltsov@mail.ru
    Anatoly I. Martynov, MD, professor, academician of RAS, professor of the Department of hospital therapy № 1, A.I. Yevdokimov Moscow state university of medicine and dentistry of the Ministry of Helthcare of Russia. Address: 127473, Moscow. 20/1 Delegatskaya St. Tel.: +74956096700


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