Comparative research of antifungal nail lacquer Loceryl with its generics offered in the Russian pharmaceutical market


DOI: https://dx.doi.org/10.18565/therapy.2019.3.156-162

Bussard L., Violette M., Kotrekhova L.P.

1) Pharmaceutical company Galderma, France; 2) I.I. Mechnikov North-Western State medical University of the Ministry of Healthcare of Russia, Saint Petersburg
Purpose of the study was to prove that Loceryl antifungal nail lacquer (the active ingredient is Amorolfine) is superior to the generic antifungal medicines with amorolfine existing on the Russian pharmaceutical market in terms of packaging quality, ease of use and physical properties (fluidity, evaporation rate, uniformity and homogeneity of the structure after surfacing).
Material and methods. Study design: comparative, blind. To test the hypothesis, a comparative assessment of a number of parameters (characteristics) of the drugs products were made. The study included 6 stages.
Results and conclusion. According to the study results, Loceryl showed the best result. Loceryl had no parameter deviations of the specifications, unlike other test products.
Keywords: Loceryl, antifungal nail lacquer, amorolfine, onychomycosis
Read entire article

Literature


  1. Gupta A.K., Mays R.R., Versteeg S.G., Shear N.H., Piguet V. Update on current approaches to diagnosis and treatment of onychomycosis. Expert Rev Anti Infect Ther. 2018; 16(12): 929–38. https://doi.org/10.1080/14787210.2018.1544891

  2. Котрехова Л.П., Разнатовский К.И., Вашкевич А.А. Особенности течения микозов кожи на современном этапе и их рациональная терапия. Дерматология. Приложение к журналу Consilium Medicum. 2014; 1: 30–34.

  3. Park K.Y., Suh J.H., Kim B.J., Kim M.N., Hong C.K. Randomized clinical trial to evaluate the efficacy and safety of combination therapy with short-pulsed 1,064-nm neodymium-doped yttrium aluminium garnet laser and amorolfine nail lacquer for onychomycosis. Ann Dermatol. 2017; 29(6): 699–705. https://doi.org/10.5021/ad.2017.29.6.699

  4. Федеральные клинические рекомендации. Дерматовенерология 2015: Болезни кожи. Инфекции, передаваемые половым путем. 5-е изд., перераб. и доп. М.: Деловой экспресс, 2016. 768 с.

  5. Sigurgeirsson B., Ghannoum M. A., Osman-Ponchet H., Kerrouche N., Sidou F. Application of cosmetic nail varnish does not affect the antifungal efficacy of amorolfine 5% nail lacquer in the treatment of distal subungual toenail onychomycosis: results of a randomized active-controlled study and in vitro assays. Mycosis 2016, 59(5): 319–26.

  6. Ghannoum M. et al. A pilot, layer-wise, ex vivo evaluation of the antifungal efficacy of amorolfine 5% nail lacquer vs other topical antifungal nail formulations in healthy toenails. Mycoses. 2019; 62(6): 494–501. https://doi: 10.1111/myc.12896. Epub 2019 Mar 18.


About the Autors

Ludovic Bussard, employees of the pharmaceutical company Galderma, Industrial Development, Galderma France. Alby sur Chéran.
Manon Violette, employees of the pharmaceutical company Galderma, Industrial Development, Galderma France. Alby sur Chéran
Lyubov P. Kotrekhova, PhD, associate professor of the dermatovenereology Department of I.I. Mechnikov North-Western State medical University of the Ministry of Healthcare of Russia. Address: 194291, Saint Petersburg, 1/28 Santiago de Cuba str. Tel.: +7 (921) 997-34-72; +7 (812) 303-51-47. E-mail: zurupalubov@inbox.ru

Back to Content

Бионика Медиа