Fatigue and quality of life in patients with sarcoidosis


DOI: https://dx.doi.org/10.18565/therapy.2019.5.77-84

Postnikova L.B., Gudim A.L., Kostrov V.A., Mironov A.A.

1) Clinical Hospital No. 38, Nizhny Novgorod 2) Lobachevsky State University of Nizhny Novgorod 3) Privolzhskiy Research Medical University of the Ministry of Healthcare of Russia, Nizhny Novgorod
Aim: to study fatigue in sarcoidosis outpatients using Fatigue Assessment Scale (FAS), to identify factors associated with fatigue, to assess the impact of fatigue on the quality of life (QOL) and the level of physical capacity.
Material and methods. A one-time comparative study included 80 sarcoidosis outpatients mediane age of 35 (39–45) years (men – 43, women – 37). Clinical characteristics, Fatigue (FAS), QOL (SF-36), laboratory parameters, resting spirometry values and cardiopulmonary exercise test results evaluated in all patients.
Results. Twenty-nine sarcoidosis patients (36.3%) had fatigue. One-factor analysis identified factors affecting the development of sarcoidosis-associated fatigue: age over 39 years, female (p<0,001), clinical symptoms (p=0,008) and extrapulmonary manifestations of sarcoidosis (p=0,031). Patients with fatigue had lower values of peak oxygen consumption (VO2peak; ml/min/kg) and peak work rate (p <0,001). But both groups were comparable in terms of VO2peak expressed as % pred (p=0,082). Multivariate analysis identified independent predictors of fatigue in sarcoidosis – identified independent predictors of fatigue in sarcoidosis outpatients – it were age and female. A significant negative correlation in patients with sarcoidosis was found between fatigue and psychological health components (r=-0,831, p <0,001) and physical health components (r=-0,813, p<0,001), which determined QOL.
Conclusion. Fatigue was found in 36.3% of patients with sarcoidosis. Independent predictors of sarcoidosis-associated fatigue were female and age over 39 years. Fatigue can be a reliable tool in assessment the quality of life of sarcoidosis patients.
Keywords: exercise capacity, cardiopulmonary exercise testing, sarcoidosis, fatigue, quality of life
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About the Autors

Larisa B. Postnikova, MD, professor, consultant of Nizhny Novgorod Oblast Clinical Hospital No. 38. Address: 603000, Nizhny Novgorod, 22 Chernyshevskogo Str. Tel.: +7 (831) 434-20-20. E-mail: plbreath@mail.ru. ORCID ID: orcid.org/0000-0002-8509-7133
Andrey L. Gudim, therapist of Nizhny Novgorod Oblast Clinical Hospital No. 38. Address: 603000, Nizhny Novgorod, 22 Chernyshevskogo Str. Tel.: +7 (831) 434-20-20. E-mail: andr6665@mail.ru. ORCID ID: orcid.org/0000-0002-0341-1708
Vladimir A. Kostrov, PhD, consultant of Nizhny Novgorod Oblast Clinical Hospital No. 38. Address: 603000, Nizhny Novgorod, 22 Chernyshevskogo Str. Tel.: +7 (831) 434-20-20. E-mail: vlakostr@yandex.ru
Andrey A. Mironov, PhD, associate professor of the N.Yu. Belenkov Department of Normal physiology of Privolzhskiy Research Medical University of the Ministry of Healthcare of Russia, associate professor of the Department of neurotechnologies of Lobachevsky State University of Nizhny Novgorod. Address: 603005, Nizhny Novgorod, 10/1 Minin and Pozharsky Sq. Tel.: +7 (831) 465-99-82, 8 (831) 462-32-02. E-mail: andreymronov@neuro.nnov.ru. ORCID ID: orcid.org/0000-0001-7387-286


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