The effectiveness of specialized diet therapy in patients with diseases of the gastrointestinal tract


DOI: https://dx.doi.org/10.18565/therapy.2020.1.141-149

Pilat T.L., Lashina E.L., Kolyaskina M.M., Bezrukavnikova L.M., Korosteleva M.M., Gurevich K.G., Lagutina N.P., Khanferyan R.A.

1) Scientific Research Institute of labour medicine named after academician N.F. Izmerov, Moscow; 2) Federal Research Center of nutrition and biotechnology, Moscow; 3) A.I. Yevdokimov Moscow State University of medicine and dentistry of the Ministry of Healthcare of Russia; 4) Peoples’ Friendship University of Russia, Moscow
Objective: to study the effectiveness of specialized diet therapy in patients with diseases of the gastrointestinal tract using 3 therapeutic and prophylactic food products (LLC «LEOVIT nutria»).
Material and methods. The main group included 41 patients, who were divided into 3 subgroups depending on the type of therapeutic and prophylactic food products. The control group included 30 patients.
The dynamics of the indicators of the clinical blood analysis and dynamics of indicators of metabolic disorders of liver function, including biosynthetic and secretory, were assessed (AST, ALT, GGT, total bilirubin). A study was also made of the dynamics of the spectrum of blood lipids by the content of total cholesterol, as well as the level of glucose in the blood on an empty stomach. All laboratory tests were carried out before the use of the products, on days 14 and 60 after the start of the use of therapeutic and prophylactic food products.
Results. The studies noted good tolerance of products, the absence of allergic reactions or any side effects, even with prolonged use of specialized products (180 days). In the main group, plasma concentrations of AST, ALT and GGT, as well as total bilirubin decreased, while in the comparison group the differences were minimal. After 180 days in the main group ESR and CRP significantly decreased. The most significant decrease of these indicators (-54% and -207% respectively) was in the subgroup receiving «Vegetable Soup with Herbs and Oatmeal» (LEOVIT GASTRO). In the subgroup receiving «Oatmeal porridge with herbs and flax seed» (LEOVIT GASTRO) by 16 and 13%, and in the subgroup receiving «Protein-sea-buckthorn cocktail» by 34 and 266% of the initial level, respectively. Moreover, in the comparison group, changes in these indicators were statistically unreliable. In all subgroups of the main group, after 180 days, a statistically significant decrease in the concentration of glucose by 6–17% and cholesterol by 9–18% from the initial level occurred.
Conclusions. The studied products have pronounced anti-inflammatory activity, have hypoglycemic and hypocholesterolemic effects, do not cause side effects, can be recommended for the general population for the prevention and treatment of gastrointestinal diseases.
Keywords: preventive and therapeutic diet, diseases of the gastrointestinal tract, specialized products, herbal medicine
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About the Autors

Tatiana L. Pilat, MD, leading researcher of Scientific Research Institute of labour medicine named after academician N.F. Izmerov. Address: 105275, Moscow, 31 Budennogo Prospect. Tel.: +7 (495) 366-06-09; +7 (495) 663-35-96.
E-mail: tpilat@leovit.ru. ORCID: 0000-0002-5930-8849; SPIN-code: 7138-3431.
Elena L. Lashina, PhD, therapist, head of the Clinical research Department of Scientific Research Institute of labour medicine named after academician N.F. Izmerov. Address: 105275, Moscow, 31 Budennogo Prospect.
Tel.: +7 (495) 365-36-00. E-mail: e.lashina@mail.ru. ORCID 0000-0002-8379-2511, SPIN-code: 2380-3857.
Maria M. Kolyaskina, PhD, Senior researcher of medico-biological research laboratory of Scientific Research Institute of labour medicine named after academician N.F. Izmerov, lecturer of the Department of labour medicine, aviation, space and diving medicine of I.M. Sechenov First Moscow State medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 105275, Moscow, 31 Budennogo Prospect. Tel.: +7 (495) 365-59-41.
E-mail: koliaskina.mm@irioh.ru. ORCID 0000-0001-5356-1598, SPIN-code: 9987-1559.
Lyudmila M. Bezrukavnikova, candidate of biological sciences, leading researcher of medico-biological research laboratory of Scientific Research Institute of labour medicine named after academician N.F. Izmerov. Address: 105275, Moscow, 31 Budennogo Prospect. Tel.: +7 (495) 365-59-41. E-mail: bezrukavnikovalm@mail.ru. ORCID0000-0002-0430-4154, SPIN-code: 8080-7210.
Margarita M. Korosteleva, PhD, Senior researcher of Sports anthropology and nutrition laboratory of Federal Research Center of nutrition and biotechnology. Address: 109240, Moscow, 2/14 Ust`insky passage Str. E-mail: korostel@bk.ru, ORCID: 0000-0002-2279-648X, SPIN-code: 5276-9459.
Konstantin G. Gurevich, MD, professor, head of the UNESCO Department of A.I. Yevdokimov Moscow State University of medicine and dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. ORCID iD is 0000-0002-7603-6064, SPIN-code: 4344-3045, AuthorID: 112982.
Natalia P. Lagutina, gastroenterologist of Scientific Research Institute of labour medicine named after academician N.F. Izmerov. Address: 105275, Moscow, 31 Budennogo Prospect. Tel.: +7 (495) 366-42-66.
Roman A. Khanferyan, MD, professor, Medicinal Institute of Peoples’ friendship University of Russia. Address: 117199, Moscow, 6 Miklukho-Maklaya Str. ORCID 0000-0003-1178-7534, SPIN-code: 1091-8405.


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