Oxidative stress and epilepsy: possible mechanisms of their interaction


DOI: https://dx.doi.org/10.18565/therapy.2020.3.39-45

Fedin A.I., Torshin D.V., Starykh E.V., Baranova O.A., Chekanov A.V., Mikhailova E.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow
The aim of this study was to investigate the oxidative stress in young patients with focal symptomatic and cryptogenic epilepsy and after the first onset of epileptic seizures.
Material and methods. The patients aged from 19 to 44 years were distributed into three groups, 30 patients in each: the patients after a few (first) epileptic seizures, the patients in the clinical remission that has lasted at least one year, and the patients with treatment-resistant epileptic seizures. In addition, the healthy control group included 20 virtually healthy persons. The parameters of the pro-oxidant status (TBA-reactive products) were studied, as well as the parameters of the antioxidant defense (AOD): the total superoxide-scavenging activity of the blood plasma, catalase, the total antioxidant activity of the blood plasma, and the reduced thiols (SH groups) of the blood plasma.
Results. Our study revealed no significant differences in the concentrations of TBA-reactive products in the blood plasma of epilepsy patients and healthy controls. As to the other parameters investigated in this study (concentration of reduced SH groups, total superoxide-scavenging activity of plasma, catalase activity), they were found to be significantly decreased in comparison with the control group, p < 0,05; for the total antioxidant activity of the blood plasma, p=0,008. In addition, some of the parameters displayed significant differences between different groups of epilepsy patients.
Conclusion. From the point of view of adaptation syndrome free-radical processes will be an essential component of stress reactions that manifest themselves immediately after the action of the stress factor (epileptic seizure) and persist in the future regardless of the course of epilepsy.
Keywords: adaptation, epilepsy, oxidative stress
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About the Autors

Anatoly I. Fedin, MD, professor, head of the Department of neurology of the Faculty of advanced medical education of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. Tel.: +7 (495) 370-00-11. E-mail: fedin.anatoly@gmail.com. ORCID: 0000-0001-6950-5697
Dmitry V. Torshin, applicant for the Department of neurology of the Faculty of advanced medical education of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, neurologist at City clinical hospital No. 13 of Moscow Healthcare Department. Address: 117997, Moscow, 1 Ostrovityanova Str. Tel.: +7 (495) 370-00-11. E-mail: torshin.dmitrii@rambler.ru. ORCID: 0000-0002-0134-5284
Elena V. Starykh, MD, professor of the Department of neurology of the Faculty of advanced medical education of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. Tel.: +7 (495) 370-00-11. E-mail: starykh_elena@mail.ru. ORCID: 0000-0002-3538-4468
Olga A. Baranova, PhD, Senior researcher of the Biomedical research laboratory of the Department of neurology of the Faculty of advanced medical education of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. Tel.: +7 (495) 370-00-11. E-mail: oabaranova@yandex.ru. ORCID: 0000-0001-9022-0426
Andrey V. Chekanov, PhD, Senior researcher of the Biomedical research laboratory of the Department of neurology of the Faculty of advanced medical education of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. Tel.: +7 (495) 370-00-11. E-mail: avchekanov@mail.ru. ORCID: 0000-0001-7737-835X
Ekaterina V. Mikhailova, student of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. Tel.: +7 (495) 434-05-43. E-mail: rsmu@rsmu.ru. ORCID: 0000-0001-8246-384X


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