Clinical case: diagnosis of gastric cancer in a young patient


DOI: https://dx.doi.org/10.18565/therapy.2021.5.136-140

Druk I.V., Pavlov A.V., Kosenok V.K., Fadeeva E.A., Pavlov A.A., Lyalyukov A.V., Drokina O.V.

1) Omsk State Medical University of the Ministry of Healthcare of Russia; 2) Regional Clinical Hospital, Omsk; 3) Sochi State University
Abstract. Poorly cohesive gastric carcinoma (signet ring cell carcinoma according to WHO classification, diffuse type of gastric cancer according to Lauren 1965 classification) is a type of cancer, consisting of cells that produce mucin, which displaces the nucleus to the periphery, which makes the cells look like a ring. One of the main causes of development is a mutation of the gene encoding the protein molecule E-cadherin (CDH1), which is responsible for intercellular connections and differentiation of epithelial cells. This case-report demonstrates the patient with signet ring cell carcinoma of the stomach and a discussion of the features of this type of cancer and diagnosis.
Keywords: diagnosis of gastric cancer, signet ring cell carcinoma, gastric cancer
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About the Autors

Inna V. Druk, MD, head of the Department of internal medicine and family medicine of continuing professional education, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644033, Omsk, 127/1 Krasny put` Str. Tel.: +7 (913) 964-15-55. E-mail: drukinna@yandex.ru
Alexey V. Pavlov, head of pathological Department of Regional Clinical Hospital. Address: 644111, Omsk, 3 Beryozovaya Str. Tel.: +7 (913) 618-41-77. E-mail: apavlov@freemail.ru
Viktor K. Kosenok, MD, head of the Department of oncology, radiation therapy of continuing professional education, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644013, Omsk, 9/1 Zavertyaeva Str. Tel.: +7 (913) 624-74-17. E-mail: victorkosenok@gmail.com
Elena A. Fadeeva, 4th year student of the Faculty of medicine, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina Str. Tel.: +7 (913) 158-98-08. E-mail: angela19991111@gmail.com
Alexey A. Pavlov, 3rd year student of the Faculty of medicine, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina Str. Tel.: +7 (913) 646-82-84. E-mail: alexey_pavlov122628@mail.ru
Alexander V. Lyalyukov, lecturer at Sochi State University. Address: 354000, Sochi, 94 Plastunskaya Str. Tel.: +7 (950) 788-46-42. E-mail: losangeles116@gmail.com
Olga V. Drokina, PhD, associate professor of the Department of propedeutics of internal medicine, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644112, Omsk, 7 Pereleta Str. Tel.: +7 (913) 975-67-15. E-mail: amans@bk.ru


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