Biomarkers in cardiology: lipocalin associated with neutrophil gelatinase (NGAL) and cardiovascular diseases


DOI: https://dx.doi.org/10.18565/therapy.2022.1.50-59

Alieva A.M., Teplova N.V., Reznik E.V., Valiev R.K., Rakhaev A.M., Kudaeva M.V., Akhmatov I.Z., Arakelyan R.A., Nikitin I.G.

1) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow; 2) A.S. Loginov Moscow Clinical Research Center of the Healthcare Department of Moscow; 3) Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labor and Social Protection of Russia, Nalchik; 4) V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia
Abstract. The purpose of this review is to consider neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic and prognostic marker in cardiovascular diseases. The results of various studies show that there is a huge scientific interest in the study of NGAL in cardiovascular pathology. It has been suggested that NGAL may be a marker of atherosclerosis, which was confirmed by a number of studies that demonstrated the overexpression of NGAL in atherosclerotic plaques in areas with high proteolytic activity. It has also been suggested that the role of NGAL in patients with coronary artery disease is associated with matrix metalloproteinase-9. Several studies have reported that NGAL is a marker of adverse cardiovascular events in patients with heart failure.
Keywords: lipocalin associated with neutrophil gelatinase (NGAL), biological markers, myocardial infarction, cardiovascular diseases, heart failure
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About the Autors

Amina M. Alieva, PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: amisha_alieva@mail.ru.
ORCID: https://orcid.org/0000-0001-5416-8579. SPIN-code: 2749-6427
Natalia V. Teplova, MD, professor, head of the Department of clinical pharmacology of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. ORCID: https://orcid.org/0000-0002-7181-4680
Elena V. Reznik, MD, professor, head of the Department of propaedeutics of internal diseases of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, general practitioner, cardiologist, doctor of functional diagnostics, ultrasound diagnostics at City Clinical Hospital No. 31 of the Healthcare Department of Moscow. Address: 117997, Moscow, 1 Ostrovityanova Str.
E-mail: elenaresnik@gmail.com. ORCID: https://orcid.org/0000-0001-7479-418X. SPIN-code: 3494-9080. Researcher ID: N-6856-2016
Ramiz K. Valiev, PhD, head of the Department of oncosurgery No. 2, A.S. Loginov Moscow Clinical Research Center of the Healthcare Department of Moscow. Address: 111123, Moscow, 86 Entuziastov Highway. E-mail: Radiosurgery@bk.ru. ORCID: https://orcid.org/0000-0003-1613-3716. SPIN-code: 2855-2867
Alik M. Rakhaev, MD, professor, head of the expert team of Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labor and Social Protection of Russia. Address: 360051, Nalchik,
47 Gorkogo Str. Е-mail: alikrahaev@yandex.ru. ORCID: https://orcid.org/0000-0001-9601-1174
Madina V. Kudaeva, doctor for medical and social expertise, therapist of expert team of Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labor and Social Protection of Russia. Address: 360009, Nalchik, 131В Tarchokova Str. Е-mail: lyalyusha1974@mail.ru
Islam Z. Akhmatov, student at the Faculty of general medicine, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bolshaya Kazachya Str.
Rosa A. Arakelyan, student at the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str.
E-mail: Elmira.sharm@yandex.ru
Igor G. Nikitin, MD, professor, head of the Department of hospital therapy No. 2 of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: igor.nikitin.64@mail.ru. ORCID: https://orcid.org/0000-0003-1699-0881


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