Русский
Frequency of detecting markers of hepatitis C among the conditionally healthy population of Tatarstan Republic
DOI: https://dx.doi.org/10.18565/therapy.2022.2.59-66
Kichatova V.S., Kyuregyan K.K., Carlsen A.A., Potemkin I.A., Asadi Mobarkhan F.A., Isaeva O.V., Lopatukhina M.A., Malinnikova E.Yu., Kravchenko I.E., Znoyko O.O., Yuschuk N.D., Mikhailov M.I.
1) I.I. Mechnikov Scientific Research Institute of Vaccines and Serums, Moscow; 2) Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia, Moscow; 3) Peoples’ Friendship University of Russia, Moscow; 4) Kazan State Medical University of the Ministry of Healthcare of Russia; 5) A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia
The aim of the study is to determine the true prevalence of HCV markers among the apparently healthy population of Tatarstan Republic (RT).
Material and methods. 913 samples of blood sera from a conditionally healthy population of Tatarstan Republic were studied. The sample included persons of 9 age groups: under one year old, 1–9 years old, 10–14 years old, 15–19 years old, 20–29 years old, 30–39 years old, 40–49 years old, 50–59 years old and over 60 years old. The presence of antibodies to the virus in the samples was checked by EIA methodic in screening and confirmatory test. All anti-HCV positive participants were screened for the presence of an ongoing infectious process by detecting HCV RNA by means of RT-PCR methodic. In samples positive for HCV RNA, the genotype of the virus was also fixed.
Results. Anti-HCV detection rates in average consisted of 2.1% (19/913; 95% CI: 1,3–3,2%), and the prevalence of current infection confirmed by HCV RNA detection was 0,9% (8/913; 95 % CI: 0,4-1,7%). In age cohorts over 60 and 30–39 years old, there were significant differences in the incidence of HCV RNA comparatively with other study groups, the analyzed index was 3,4% (4/119; 95% CI: 1,0–8,6%) and 2,7% (3/112; 95% CI: 0,5–7,9%), respectively. Phylogenetic analysis showed the division of the studied HCV isolates into subtypes 1a (n=1), 1b (n=2), 2a (n=2) and 3a (n=3).
Conclusion. In general, among the conditionally healthy population of Tatarstan Republic, an average level of prevalence of HCV infection was revealed. Individuals aged 30–39 years and older than 60 years are the cohorts in which more careful monitoring of the spread of HCV is needed, while the presence of risk factors for infection is an index of less diagnostical importance.
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About the Autors
Vera S. Kichatova, PhD in Medicine, researcher at the Laboratory of viral hepatitis, I.I. Mechnikov Scientific Research Institute of Vaccines and Serums, researcher at Research Institute of Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia. Address: 125284, Moscow, 7/2 2nd Botkinskiy Drive. E-mail: vera_kichatova@mail.ru. ORCID: http://orcid.org/0000-0002-7838-6965
Karen K. Kyureghyan, Dr. habil. biol., professor of RAS, chief researcher at Research Institute of Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia, leading researcher at Research and Educational Resource Center «High-Performance Methods of Genomic Analysis», Peoples’ Friendship University of Russia, leading researcher at the Laboratory of viral hepatitis, I.I. Mechnikov Scientific Research Institute of Vaccines and Serums. Address: 125993, Moscow, д. 2/1, build. 1 Barrikadnaya Str. E-mail: karen-kyuregyan@yandex.ru. ORCID: http://orcid.org/0000-0002-3599-117X
Anastasia A. Carlsen, researcher at Research and Educational Resource Center «High-Performance Methods of Genomic Analysis», Peoples’ Friendship University of Russia, leading researcher at the Laboratory of viral hepatitis, I.I. Mechnikov Scientific Research Institute of Vaccines and Serums. Address: 125993, Moscow, д. 2/1, build. 1 Barrikadnaya Str. E-mail: karlsen12@gmail.com. ORCID: http://orcid.org/0000-0002-6013-7768
Ilya A. Potemkin, PhD in Medicine, researcher at the Department of viral hepatitis studies, Research Institute of Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia, researcher at the Laboratory of viral hepatitis, I.I. Mechnikov Scientific Research Institute of Vaccines and Serums. Address: 125993, Moscow, д. 2/1, build. 1 Barrikadnaya Str. E-mail: axi0ma@mail.ru.
ORCID: http://orcid.org/0000-0001-7559-4219
Fedor A. Asadi Mobarkhan, researcher at the Department of viral hepatitis studies, Research Institute of Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia, researcher at the Laboratory of viral hepatitis, I.I. Mechnikov Scientific Research Institute of Vaccines and Serums. Address: 105064, Moscow, 5A Maliy Kazenniy Lane. E-mail: 1amfa@bk.ru.
ORCID: http://orcid.org/0000-0002-1838-8037
Olga V. Isaeva, PhD in Biology, leading researcher at the Department of viral hepatitis studies, Research Institute of Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia, leading researcher at the Laboratory of viral hepatitis, I.I. Mechnikov Scientific Research Institute of Vaccines and Serums. Address: 125993, Moscow, д. 2/1, build. 1 Barrikadnaya Str. E-mail: isaeva.06@mail.ru. ORCID: http://orcid.org/0000-0002-2656-3667
Maria A. Lopatukhina, researcher at the Laboratory of viral hepatitis, I.I. Mechnikov Scientific Research Institute of Vaccines and Serums. Address: 105064, Moscow, 5A Maliy Kazenniy Lane. E-mail: m.lopatukhina@gmail.com.
ORCID: http://orcid.org/0000-0001-6853-4154
Elena Yu. Malinnikova, Dr. med. habil., professor, head of the Department of virology, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia, leading researcher at the Laboratory of viral hepatitis, I.I. Mechnikov Scientific Research Institute of Vaccines and Serums. Address: 125445, Moscow, 19/38 Belomorskaya Str. E-mail: malinacgb@mail.ru. ORCID: http://orcid.org/0000-0002-5501-5707
Irina E. Kravchenko, Dr. med. habil., professor of the Department of infectious diseases, Kazan State Medical University of the Ministry of Healthcare of Russia, chief freelance specialist in infectious diseases of the Ministry of Healthcare of Russia in the Volga Federal District. Address: 420012, Kazan, 49 Butlerova Str. E-mail: kravchencoie@mail.ru.
ORCID: http://orcid.org/0000-0003-4408-7542
Olga O. Znoyko, Dr. med. habil., professor of the Department of infectious diseases and epidemiology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: olgaznoyko@yandex.ru. ORCID: http://orcid.org/0000-0002-4965-596X
Nikolai D. Yushchuk, Dr. med. habil., professor, academician of RAS, president of A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia, head of the Department of infectious diseases and epidemiology. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: prof.uyshuk@gmail.com.
ORCID: http://orcid.org/0000-0002-4003-4622
Mikhail I. Mikhailov, Dr. med. habil., professor, corresponding member of RAS, scientific director of Research Institute of Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia, head of the Laboratory of viral hepatitis, I.I. Mechnikov Scientific Research Institute of Vaccines and Serums. Address: 125993, Moscow, д. 2/1, build. 1 Barrikadnaya Str. E-mail: michmich2@yandex.ru. ORCID: http://orcid.org/0000-0002-6636-6801
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