Antibiotic-associated diarrhea in modern realities


DOI: https://dx.doi.org/10.18565/therapy.2022.6.158-163

Luzina E.V., Lareva N.V., Zhilina A.A., Zhigzhitova E.B., Tomina E.A.

Chita State Medical Academy of the Ministry of Healthcare of Russia
Abstract. Antibiotic-associated diarrhea (AAD) is one of the undesirable effects of antibiotic therapy. Recently, however, the relevance of AAD has become particularly important due to the increase in morbidity and mortality against the backdrop of the COVID-19 pandemic. There are several mechanisms for the formation of diarrhea when taking antibacterial drugs, among which infectious AAD has the most unfavorable course. The article discusses the features of the clinical course of diarrhea, characteristic of different pathogens. Literature data on the risk factors for the occurrence of AAD, the features of the course of the disease in children and adults are given. Approaches to the diagnosis and treatment of diarrhea in COVID-19 are highlighted. The provisions of the recommendations of the Russian Gastroenterological Association for the treatment of Clostridium difficile-associated disease are presented. Particular attention is paid to the review of recent literature on the use of probiotics for the prevention of AAD.
Keywords: COVID-19, antibiotic-associated diarrhea, Clostridium difficile
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About the Autors

Elena V. Luzina, PhD in Medicine, associate professor of the Department of therapy of FAPE, Chita State Medical Academy of the Ministry of Healthcare of Russia, Chairman of the Trans-Baikal Scientific Society of Gastroenterologists. Address: 672090, Chita, 39а Gor`kogo Str. E-mail: el.luz@list.ru. ORCID: https://orcid.org/0000-0002-8282-3056. eLibrary SPIN: 6748-9361
Natalia V. Lareva, Dr. med. habil., professor, vice-rector for scientific and international affairs, head of the Department of therapy of FAPE, Chita State Medical Academy of the Ministry of Healthcare of Russia, Chairman of the Trans-Baikal regional branch of RSMSIM. ORCID: https://orcid.org/0000-0001-9498-9216. eLibrary SPIN: 1228-6205
Albina A. Zhilina, PhD in Medicine, associate professor of the Department of therapy of FAPE, Chita State Medical Academy of the Ministry of Healthcare of Russia. ORCID: https://orcid.org/0000-0002-4405-2975
Evgenia B. Zhigzhitova, PhD in Medicine, assistant at the Department of therapy of FAPE, Chita State Medical Academy of the Ministry of Healthcare of Russia. ORCID: https://orcid.org/0000-0002-5288-1298
Elena A. Tomina, PhD in Medicine, assistant at the Department of therapy of FAPE, Chita State Medical Academy of the Ministry of Healthcare of Russia. ORCID: https://orcid.org/0000-0003-2423-666X


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