Severe pseudomembranosic colitis with encephalopathy and edemate syndrome


DOI: https://dx.doi.org/10.18565/therapy.2022.8.90-94

Khamidova Kh.A., Panchenkova L.A., Bulanova N.A., Karnuta G.G., Zinovieva S.Yu., Khomyakova T.D., Popov V.V.

1) A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia; 2) G.R. Derzhavin Tambov State University; 3) CH «RZD-Medicine» named after N.A. Semashko, Moscow; 4) Central State Medical Academy of the Administration of the President of the Russian Federation, Moscow; 5) Medical Institute of continuing education of Moscow State University of Food Production
Abstract. During the pandemic, the number of cases of pseudomembranous colitis in patients infected with SARS-CoV-2 increased significantly. The article presents a clinical case of pseudomembranous colitis in a 68-year-old female patient during hospitalization for COVID-19. The peculiarity of this case is the dominance of encephalopathy manifestations in common clinical picture, in connection with which the patient was urgently hospitalized in the neurological department with acute cerebrovascular accident referral diagnosis. The development of severe encephalopathy in patients with pseudomembranous colitis is taking place due to a direct toxic effect at the central nervous system of enterotoxin TcdB Clostridium difficile. Pleural effusion and ascites were other main clinical manifestations of pseudomembranous colitis in current clinical observation.
Keywords: Clostridium difficile-associated infection, COVID-19, encephalopathy, ascites, pleural effusion, pseudomembranous colitis, Clostridium difficile
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About the Autors

Khadizhat A. Khamidova, PhD in Medicine, associate professor of the Department of hospital therapy No.1, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 125367, Moscow, 84 Volokolamskoe Highway. E-mail: K.Khamidova@mail.ru. ORCID: https://orcid.org/0000-0001-9558-3613
Lyudmila A. Panchenkova, Dr. med. habil., professor, professor of the Department of hospital therapy No. A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 125367, Moscow, 84 Volokolamskoe Highway. E-mail: lapanchenkova@mail.ru
Natalia A. Bulanova, Dr. med. habil., associate professor, professor of the Department of hospital therapy, G.R. Derzhavin Tambov State University, associate professor of the Department of emergency medicine, emergency and extreme medicine, Central State Medical Academy of the Administration of the President of the Russian Federation. Address: 121359, Moscow, 19 build 1A Marshala Timoshenko Str. E-mail: bulanovanatalia@mtu-net.ru.
ORCID: https://orcid.org/0000-0001-7559-7030P
Galina G. Karnuta, PhD in Medicine, head of the Department of gastroenterology, CH «RZD-Medicine» named after N.A. Semashko. Address: 109386, Moscow, 23 build. 1 Stavropolskaya Str. E-mail: info@semashko.com
Svetlana Yu. Zinovieva, doctor at the Department of gastroenterology, CH «RZD-Medicine» named after N.A. Semashko. Address: 109386, Moscow, 23 build. 1 Stavropolskaya Str. E-mail: info@semashko.com
Tatyana D. Khomyakova, chief physician of CH «RZD-Medicine» named after N.A. Semashko. Address: 109386, Moscow, 23 build. 1 Stavropolskaya Str. E-mail: info@semashko.com
Vladimir V. Popov, Dr. med. habil., professor of the Department of pharmacology and biochemistry, G.R. Derzhavin Tambov State University, professor of the Department of therapy with a course of pharmacy, Medical Institute of continuing education of Moscow State University of Food Production, doctor – clinical pharmacologist. Address: 125080, Moscow, 11 Volokolamskoe Highway. E-mail: clinpharmcb6@mail.ru. ORCID: https://orcid.org/0000-0002-1570-2748


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