Русский
Clinical and epidemiological characteristics of neurological variants of post-COVID syndrome on the example of the neurological clinic of the Novosibirsk State Regional Clinical Hospital
DOI: https://dx.doi.org/10.18565/therapy.2022.9.22-27
Schepankevich L.A., Arkhipov I.E., Polyanskaya V.V., Veretelnikov I.A., Taneeva E.V.
1) Novosibirsk State Medical University of the Ministry of Healthcare of Russia; 2) Federal Research Center for Fundamental and Translational Medicine, Novosibirsk; 3) Novosibirsk State Regional Clinical Hospital
The aim is to study clinical and epidemiological characteristic of neurological variants of post-covid syndrome on the example of the neurological clinic of Novosibirsk state regional clinical hospital for the period from July 2020 to February 2022.
Material and methods. A retrospective analysis of 1500 case histories of patients with a history of COVID-19 in anamnesis and admitted with manifesting neurological diseases was performed for the period from July 2020 to February 2022.
Results. In the study of case histories, 30 patients were identified who had manifesting neurological diseases, in time and pathogenetically associated with previous COVID-19. In this category of patients, a predominant lesion of the central nervous system was observed in 74% of cases, the peripheral nervous system - in 23%, in 3% there was a musculoskeletal pathology represented by idiopathic myodystrophy.
Conclusion. The frequency of neurological variants of post-COVID syndrome is currently unknown, however, there is a tendency that patients with a history of severe COVID-19 are more susceptible to the development of neurological complications after infection in the period up to 6 months.
Literature
1. Pezzini A., Padovani A. Lifting the mask on neurological manifestations of COVID-19. Nat Rev Neurol. 2020; 16(11): 636–44.https://dx.doi.org/10.1038/s41582-020-0398-3.
2. Barrantes F.J. Central nervous system targets and routes for SARS-CoV-2: Current views and new hypotheses. ACS Chem Neurosci. 2020; 11(18): 2793–803. https://dx.doi.org/10.1021/acschemneuro.0c00434.
3. Brann D.H., Tsukahara T., Weinreb C. et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv. 2020; 6(31): eabc5801. https://dx.doi.org/10.1126/sciadv.abc5801.
4. Jose R.J., Manuel A. COVID-19 cytokine storm: The interplay between inflammation and coagulation. Lancet Respir Med. 2020; 8(6): e46–e47. https://dx.doi.org/10.1016/S2213-2600(20)30216-2.
5. Mainali S., Darsie M. Neurologic manifestations & associations of COVID-19. Pract Neurol. 2021: 1: 42–47.
6. Taquet M., Geddes J.R., Husain M. et al. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: A retrospective cohort study using electronic health records. Lancet Psychiatry. 2021; 8(5): 416–27.https://dx.doi.org/10.1016/S2215-0366(21)00084-5.
7. Lopez-Leon S., Wegman-Ostrosky T., Perelman C. et al. More than 50 long-term effects of COVID-19: A systematic review and meta-analysis. medRxiv. 2021: 2021.01.27.21250617. https://dx.doi.org/10.1101/2021.01.27.21250617. Preprint.
8. Lechien J.R., Chiesa-Estomba C.M., De Siati D.R. et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): A multicenter European study. Eur Arch Otorhinolaryngol. 2020; 277(8): 2251–61. https://dx.doi.org/10.1007/s00405-020-05965-1.
9. Mao L., Jin H., Wang M. et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020; 77(6): 683–90. https://dx.doi.org/10.1001/jamaneurol.2020.1127.
10. Roman G.C., Gracia F., Torres A. et al. Acute transverse myelitis (ATM): Clinical review of 43 patients with COVID-19-associated ATM and 3 post-vaccination ATM serious adverse events with the ChAdOx1 nCoV-19 vaccine (AZD1222). Front Immunol. 2021; 12: 653786. https://dx.doi.org/10.3389/fimmu.2021.653786.
11. Цыган Н.В., Рябцев А.В., Одинак М.М., Литвиненко И.В. Частота и патофизиологическое обоснование развития неврологических симптомов при COVID-19. Известия Российской Военно-медицинской академии. 2021; 40(4): 33–42. [Tsygan N.V., Ryabtsev A.V., Odinak M.M., Litvinenko I.V. The incidence and pathophysiology of neurological symptoms in COVID-19. Izvestiya Rossiyskoy Voyenno-meditsinskoy akademii = Russian Military Medical Academy Reports. 2021; 40(4): 33–42 (In Russ.)].https://dx.doi.org/10.17816/rmmar83617. EDN: ZBDGSB.
12. Долгополов И.С., Менткевич Г.Л., Рыков М.Ю., Чичановская Л.В. Неврологические нарушения у пациентов с long COVID синдромом и методы клеточной терапии для их коррекции: обзор литературы. Сеченовский вестник. 2021; 12(3): 56–67. [Dolgopolov I.S., Mentkevich G.L., Rykov M.Yu., Chichanovskaya L.V. Neurological disorders in patients with long covid syndrome and cell therapy methods for their correction a literature review. Sechenovskiy vestnik = Sechenov Medical Journal. 2021; 12(3): 56–67 (In Russ.)]. https://dx.doi.org/10.47093/2218-7332.2021.12.3.56-67. EDN: LDAZRR.
13. Wang F., Kream R.M., Stefano G.B. Long-term respiratory and neurological sequelae of COVID-19. Med Sci Monit. 2020; 26: e928996. https://dx.doi.org/10.12659/MSM.928996.
14. Stefanou M.I., Palaiodimou L., Bakola E. et al. Neurological manifestations of long-COVID syndrome: A narrative review. Ther Adv Chronic Dis. 2022; 13: 20406223221076890. https://dx.doi.org/10.1177/20406223221076890.
15. Palaiodimou L., Stefanou M.I., Katsanos A.H. et al. Prevalence, clinical characteristics and outcomes of Guillain–Barre syndrome spectrum associated with COVID-19: A systematic review and meta-analysis. Eur J Neurol. 2021; 28(10): 3517–29.https://dx.doi.org/10.1111/ene.14860.
16. Белопасов В.В., Яшу Я., Самойлова Е.М., Баклаушев В.П. Поражение нервной системы при СOVID-19. Клиническая практика. 2020; 11(2): 60–80. [Belopasov V.V., Yachou Ya., Samoilova E.M., Baklaushev V.P. The nervous system damage in COVID-19. Klinicheskaya praktika = Journal of Clinical Practice. 2020; 11(2): 60–80 (In Russ.)].https://dx.doi.org/10.17816/clinpract34851. EDN: JLSSLO.
17. Гусев Е.И., Мартынов М.Ю., Бойко А.Н. с соавт. Новая коронавирусная инфекция (COVID-19) и поражение нервной системы: механизмы неврологических расстройств, клинические проявления, организация неврологической помощи. Журнал неврологии и психиатрии им. С.С. Корсакова. 2020; 120(6): 7–16. [Gusev E.I., Martynov M.Yu., Boyko A.N. et al. Novel coronavirus infection (COVID-19) and nervous system involvement: pathogenesis, clinical manifestations, organization of neurological care. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry. 2020; 120(6): 7–16 (In Russ.)]. https://dx.doi.org/10.17116/jnevro20201200617. EDN: RNIJKY.
18. Graham E.L., Clark J.R., Orban Z.S. et al. Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized Covid-19 «long haulers». Ann Clin Transl Neurol. 2021; 8(5): 1073–85. https://dx.doi.org/10.1002/acn3.51350.
About the Autors
Larisa A. Shchepankevich, Dr. med. habil., associate professor, head of the Department of neurology, Novosibirsk State Medical University of the Ministry of Healthcare of Russia, chief researcher at Federal Research Center for Fundamental and Translational Medicine, curator of the 8th neurological Department of Novosibirsk State Regional Clinical Hospital. Address: 630091, Novosibirsk, 52 Krasny Avenue. E-mail: shepankevich@rambler.ru. ORCID: https://orcid.org/0000-0001-6951-2205
Ivan E. Arkhipov, neurologist at Novosibirsk State Regional Clinical Hospital Address: 630087, Novosibirsk, 130 Nemirovicha–Danchenko Str. E-mail: sicvel1739@list.ru. ORCID: https://orcid.org/0000-0003-2740-6388
Veronika V. Polyanskaya, 6th year student of the faculty of general medicine, Novosibirsk State Medical University of the Ministry of Healthcare of Russia. Address: 630091, Novosibirsk, 52 Krasny Avenue. E-mail: nika.veonika@gmail.com. ORCID: https://orcid.org/0000-0002-5122-2549
Ivan A. Veretelnikov, head of the 8th neurological Department of Novosibirsk State Regional Clinical Hospital. Address: 630087, Novosibirsk, 130 Nemirovicha–Danchenko Str. E-mail: shepankevich@rambler.ru. ORCID: https://orcid.org/0000-0002-8587-5679
Elena V. Taneeva, chief neurologist at the Novosibirsk region, head of the Regional Vascular Center No. 2 of Novosibirsk State Regional Clinical Hospital. Address: 630087, Novosibirsk, 130 Nemirovicha–Danchenko Str. E-mail: tev@oblmed.nsk.ru. ORCID: https://orcid.org/0000-0002-6538-6069
Similar Articles
