Peculiarities of influenza vaccination in 2022–2023 season


DOI: https://dx.doi.org/10.18565/therapy.2022.9.139-144

Tokin I.I., Yapparov R.G., Lioznov D.A.

1) A.A. Smorodintsev Influenza Research Institute of the Ministry of Healthcare of Russia, Saint Petersburg; 2) I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia, Saint Petersburg; 3) Republican Center for the Prevention and Control of AIDS and Infectious Diseases of the Republic of Bashkortostan, Ufa; 4) Bashkir State Medical University of the Ministry of Healthcare of Russia, Ufa; 5) Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia
Abstract. Influenza remains to be one of the most common infections, due to its ubiquity, annual outbreaks and epidemics. That is why vaccination against this disease is of a central importance. The article considers most of the influenza vaccines registered in Russia that are relevant in the current season, their features, composition and advantages. Tactics of vaccination of various population groups and the specifics of vaccines use are described, including taking into account ongoing vaccination against COVID-19. Recommendations are given on the use of this group of immunobiological preparations, including aspects of vaccination of pregnant women and persons belonging to other risk groups.

Literature


1. Gessner B.D., Shindo N., Briand S. Seasonal influenza epidemiology in sub-Saharan Africa: A systematic review. Lancet Infect Dis. 2011; 11(3): 223–35. https://dx.doi.org/10.1016/S1473-3099(11)70008-1.


2. Centers for Disease Control and Prevention (CDC). Influenza vaccination: A summary for clinicians. URL: https://www.cdc.gov/flu/professionals/vaccination/vax-summary.htm#:~:text=Everyone%206%20months%20of%20age,risk%20for%20serious%20influenza%20complications (date of access – 01.11.2022).


3. Медицинский вестник. ВОЗ объявила состав вакцин от гриппа сезона 2022–2023 годов. 28.02.2022. Доступ: https://medvestnik.ru/content/news/VOZ-obyavila-sostav-vakcin-ot-grippa-sezona-2022-2023-godov.html (дата обращения – 01.11.2022). [Medical Bulletin. WHO announces composition of influenza vaccines for 2022–2023 season. URL: https://medvestnik.ru/content/news/VOZ-obyavila-sostav-vakcin-ot-grippa-sezona-2022-2023-godov.html (date of access – 01.11.2022) (In Russ.)].


4. Vaccines against influenza WHO position paper. Wkly Epidemiol Rec. 2012; 87(47): 461–76.


5. World Health Organization. Virological surveillance updates.URL: http://www.who.int/influenza/gisrs_laboratory/updates/summaryreport (date of access – 01.11.2022).


6. Ерофеева М.К., Максакова В.Л., Шахланская Е.В. с соавт. Профилактическая эффективность гриппозных вакцин в современных условиях (обзор литературы). Фарматека. 2020; 27(1): 7–13. [Erofeeva M.K., Maksakova V.L., Shakhlanskaya E.V. et al. Preventive efficacy of influenza vaccines in modern conditions (literature review). Farmateka. 2020; 27(1): 7–13 (In Russ.)].https://dx.doi.org/10.18565/pharmateca.2020.1.7-13. EDN: UESDUI.


7. Ghendon Y. Vaccination against influenza viruses: Current status. Adv Biotechnol Processes. 1990; 14: 159–201.


8. Nichol K. Efficacy/clinical effectiveness of inactivated influenza virus vaccines in adults. Textbook of Influenza. In: Nicholson K.G., Webster R.G., Hay A.J. (eds). Textbook of Influenza. Oxford: Blackwell Science. 1998: pp. 358–372. ISBN: 978-0632-04803-8.


9. Wong K.K., Jain S., Blanton L. et al. Influenza-associated pediatric deaths in the United States, 2004–2012. Pediatrics 2013; 132(5): 796–804. https://dx.doi.org/10.1542/peds.2013-1493.


10. Millman J., Reed C., Kirley P.D. et al. Chaves improving accuracy of influenza-associated hospitalization rate estimates. Emerg Infect Dis. 2015; 21(9): 1595–601. https://dx.doi.org/10.3201/eid2109.141665.


11. Приказ Министерства здравоохранения Российской Федерации от 14 сентября 2020 г. № 967н «О внесении изменения в приложение n 1 к приказу Министерства Здравоохранения Российской Федерации от 21 марта 2014 г. n 125н «Об утверждении Национального календаря профилактических прививок и календаря профилактических прививок по эпидемическим показаниям»». [Order of the Ministry of Healthcare of the Russian Federation dated September 14, 2020 No. 967n «On Amendments to Appendix n 1 to Order of the Ministry of Healthcare of the Russian Federation dated March 21, 2014 n 125n “On Approval of the National Calendar of Preventive Immunizations and the Calendar of Preventive Immunizations for Epidemic Indications”» (In Russ.)].


12. World Health Organization. Strategic Advisory Group of Experts on Immunization (SAGE).URL: https://www.who.int/immunization/policy/sage/en/ (date of access – 01.11.2022).


13. Рекомендации СКГЭ ВОЗ по вакцинации против сезонного гриппа в период пандемии COVID-19. Временные рекомендации. 21 сентября 2020 г. Доступ: https://www.who.int/ru/publications/m/item/who-sage-seasonal-influenza-vaccination-recommendations-during-the-covid-19-pandemic (дата обращения – 01.11.2022). [Recommendations of the Strategic WHO Expert Advisory Group on seasonal influenza vaccination during the COVID-19 pandemic. Interim recommendations. September 21, 2020. URL: https://www.who.int/ru/publications/m/item/who-sage-seasonal-influenza-vaccination-recommendations-during-the-covid-19-pandemic (date of access – 01.11.2022) (In Russ.)].


14. Яппаров Р.Г., Карнаухова Е.Ю., Антонова Т.В., Лиознов Д.А. Иммунный ответ на вакцинацию против гриппа у больных ВИЧ-инфекцией. ВИЧ-инфекция и иммуносупрессии. 2020; 12(1): 75–82. [Yapparov R.G., Karnaukhova E.Yu., Antonova T.V., Lioznov D.A. Immune response to influenza vaccination in HIV patients. 2020; 12(1): 75–82 (In Russ.)]. https://dx.doi.org/10.22328/2077-9828-2020-12-1-75-82. EDN: JQJUQZ.


15. Talbot H.K., Coleman L.A., Zhu Y. et al. Factors associated with maintenance of antibody responses to influenza vaccine in older, community-dwelling adults. 2015; 15: 195. https://dx.doi.org/10.1186/s12879-015-0926-8.


16. Gillard P., Chu D.W., Hwang S.-J. et al. Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults. BMC Infect Dis. 2014; 14: 142. https://dx.doi.org/10.1186/1471-2334-14-142.


17. ГОСТ Р 52379-2005 «Национальный стандарт российской федерации надлежащая клиническая практика Good Clinical Practice (GCP)» (утвержден Приказом Федерального агентства по техническому регулированию и метрологии от 27 сентября 2005 г. № 232-ст). [GOST R 52379-2005 «National Standard of the Russian Federation Good Clinical Practice (GCP)» (approved by the Order of the Federal Agency for Technical Regulation and Metrology dated September 27, 2005 No. 232-st) (In Russ.)].


18. Федеральный закон от 12.04.2010 № 61-ФЗ «Об обращении лекарственных средств» (в ред. Федеральных законов от 27.07.2010 № 192-ФЗ, от 11.10.2010 N 271-ФЗ, от 29.11.2010 № 313-ФЗ, от 06.12.2011 № 409-ФЗ, от 25.06.2012 № 93-ФЗ, от 25.12.2012 № 262-ФЗ, от 02.07.2013 № 185-ФЗ, от 25.11.2013 № 317-ФЗ, от 12.03.2014 № 33-ФЗ, от 22.10.2014 № 313-ФЗ). [Federal Law No. 61-FZ of April 12, 2010 «On the Circulation of Medicines» (as amended by Federal Laws No. 192-FZ of July 27, 2010, No. 271-FZ of October 11, 2010, No. 313-FZ of November 29, 2010, of December 6, 2010) .2011 No. 409-FZ, dated 25.06.2012 No. 93-FZ, dated 25.12.2012 No. 262-FZ, dated 02.07.2013 No. 185-FZ, dated 25.11.2013 No. 317-FZ, dated 12.03.2014 No. 33- FZ, dated October 22, 2014 No. 313-FZ) (In Russ.)].


19. Руководство по экспертизе лекарственных средств. Том I. М.: Гриф и К. 2013; 328 с. [Guidelines for the examination of medicines. Volume I. Moscow: Grif i K. 2013; 328 pp. (In Russ.)]. ISBN: 978-8125-1858-5.


20. Лиознов Д.А., Харит С.М., Ерофеева М.К. с соавт. Оценка реактогенности и иммуногенности вакцины гриппозной четырехвалентной инактивированной субъединичной. Эпидемиология и вакцинопрофилактика. 2018; 17(3): 57–62. [Lioznov D.A., Kharit S.M., Erofeeva M.K. et al. Assessment of reactogenicity and immunogenicity of the quadrivalent live attenuated influenza vaccine. Epidemiologiya i vaktsinoprofilaktika = Epidemiology and Vaccinal Prevention. 2018; 17(3): 57–62 (In Russ.)].https://dx.doi.org/10.31631/2073-3046-2018-17-3-57-62. EDN: URQFMQ.


21. Ерофеева М.К., Стукова М.А., Шахланская Е.В. с соавт. Оценка профилактической эффективности гриппозных вакцин. Эпидемиология и вакцинопрофилактика. 2021; 20(5): 52–60. [Erofeeva M.K., Stukova M.A., Shakhlanskaya E.V. et al. Evaluation of the preventive effectiveness of influenza vaccines in the epidemic season 2019–2020 in St. Petersburg. Epidemiologiya i vaktsinoprofilaktika = Epidemiology and Vaccinal Prevention. 2021; 20(5): 52–60 (In Russ.)].https://dx.doi.org/10.31631/2073-3046-2021-20-5-52-60. EDN: ZCBUZK.


22. Никифорова А.Н., Исакова-Сивак И.Н., Ерофеева М.К. с соавт. Результаты изучения безопасности и иммуногенности отечественной субъединичной адъювантной вакцины Совигрипп у добровольцев 18–60 лет. Эпидемиология и вакцинопрофилактика. 2014; 2: 72–78. [Nikiforova A.N., Isakova-Sivak I.N., Erofeeva M.K. et al. The results of studying the safety and immugenicity of domestic subunit adjuvanted vaccine Sovigripp in volunteers from 18 to 60 years old. Epidemiologiya i vaktsinoprofilaktika = Epidemiology and Vaccinal Prevention. 2014; 2: 72–78 (In Russ.)]. EDN: SBEUNX.


23. Фельдблюм И.В., Субботина К.А., Новгородова С.Д. с соавт. Реактогенность, безопасность и иммуногенность отечественной гриппозной инактивированной расщепленной вакцины Флю-М при иммунизации взрослых 18–60 лет. Журнал микробиологии, эпидемиологии и иммунобиологии. 2018; 5: 31–37. [Feldblyum I.V., Subbotina K.A., Novgorodova S.D. et al. Reactogenicity, safety and immunogenicity of domestic Flu-M inactivated split influenza vaccine for the immunization of adults aged between 18 and 60. Zhurnal mikrobiologii, epidemiologii i immunobiologii = Journal of Microbiology, Epidemiology and Immunobiology. 2018; 5: 31–37 (In Russ.)]. https://dx.doi.org/10.36233/0372-9311-2018-5-31-37. EDN: FKNUUT.


About the Autors


Ivan I. Tokin, PhD in Medicine, head of the Department of experimental and clinical research, A.A. Smorodintsev Influenza Research Institute of the Ministry of Healthcare of Russia, associate professor of the Department of infectious diseases, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 197376, Saint Petersburg, 15/17 Professora Popova Str. E-mail: ivan.tokin@influenza.spb.ru. ORCID: https://orcid.org/0000-0002-9824-3945
Rafael G. Yapparov, PhD in Medicine, associate professor of the Department of infectious diseases with IFVE course, Bashkir State Medical University of the Ministry of Healthcare of Russia, chief physician of Republican Center for the Prevention and Control of AIDS and Infectious Diseases. Address: 450005, Ufa, 18 Kustarnaya Str. E-mail: rafdok@yandex.ru
Dmitry A. Lioznov, Dr. med. habil., professor, director of A A. Smorodintsev Influenza Research Institute of the Ministry of Healthcare of Russia, head of the Department of infectious diseases and epidemiology, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197376, Saint Petersburg, 15/1€ Professora Popova Str. ORCID: https://orcid.org/0000-0003-3643-7354


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