Pathogenetic therapy in case of COVID-19: decreasing of key hyper inflammatory response factors production


DOI: https://dx.doi.org/10.18565/therapy.2023.10.118-125

Nikolaeva S.V.

Central Research Institute of Epidemiology of Rospotrebnadzor, Moscow
Abstract. Novel coronavirus infection has led to high morbidity and mortality throughout the whole world. There are several genovariants of the SARS-CoV-2 virus, including Delta (B.1.617.2) and Omicron (B.1.1.529). Delta variant is associated with more severe course of infection, while Omicron resulted in a significant increase in the total number of infected individuals. Upper respiratory tract damage symptoms and fever remain the most common symptoms of COVID-19, but extrapulmonary complications affecting the cardiovascular, central nervous system, and gastrointestinal tract may also develop. Proactive treatment before the full symptom complex of life-threatening conditions (pneumonia, ARDS, sepsis) develops is a major challenge in COVID-19 control. Prescribing of medicines that can reduce the production of key factors of the hyperinflammatory response in COVID-19, in particular cytokines interleukin 6 and interleukin 8, could be considered to be a promising direction in pathogenetic therapy of the disease.

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About the Autors


Svetlana V. Nikolaeva, MD., leading researcher at the clinical Department of infectious pathology, Central Research Institute of Epidemiology of Rospotrebnadzor. Address: 111123, Moscow, 3a Novogireevskaya Str. E-mail: nikolaeva008@list.ru


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