A clinical case of amyloid cardiomyopathy in association of t-cell leukemia


DOI: https://dx.doi.org/10.18565/therapy.2023.4.88-97

Klyagina K.I., Adasheva T.V., Mershina E.A., Goruleva E.I., Semochkin S.V., Chernysheva O.O., Shakhrai N.B.

1) A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia; 2) Medical scientific and educational center of M.V. Lomonosov Moscow State University; 3) Hospital of the Centrosoyuz of the Russian Federation, Moscow; 4) Moscow Medical Institute «REAVIZ»; 5) P.A. Herzen Moscow Scientific Research Institute of Oncology – a branch of National Medical Research Center for Radiology of the Ministry of Healthcare of Russia, Moscow; 6) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow
Abstract. The article presents a clinical case of amyloid cardiomyopathy that developed in the presence of T-cell leukemia from large granular lymphocytes. The stages of diagnostic search are described, the causes of late diagnosis of the disease are analyzed. Pathogenetic substantiation of the mechanisms of development of plasma cell monoclonal dyscrasia against the background of T-cell leukemia is given. The presented clinical case shows the complexity and multi-stage character of the diagnosis of amyloid cardiomyopathy, need for rapid diagnosis due to the rapid progression of the disease.
Keywords: large granular lymphocyte leukemia, T-cell leukemia, AL amyloid cardiomyopathy, amyloidosis
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About the Autors

Tatyana V. Adasheva, MD, professor, professor of the Department of therapy and preventive medicine, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: adashtv@mail.ru. ORCID: 0000-0002-3763-8994
Kristina I. Klyagina, clinical resident of the Department of therapy and preventive medicine, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: mcm3439@yandex.ru. ORCID: https://orcid.org/0009-0006-7219-6403
Elena A. Mershina, PhD in Medical Sciences, head of the Department of X-ray diagnostics, leading researcher at the Department of radiation diagnostics of the Medical scientific and educational center of M.V. Lomonosov Moscow State University. Address: 119991 Moscow, 27/10 Lomonosovskiy Avenue. E-mail: elena_mershina@mail.ru
Ekaterina I. Goruleva, PhD in Medical Sciences, associate professor of the Department of internal diseases of the Moscow medical university «Reaviz», head of the therapy Department of the Hospital of the Centrosoyuz of the Russian Federation. Address: 107150, Moscow, 39 Losinoostrovskaya Str. E-mail: ekaterina.gorulyova@gmail.com. ORCID: https://orcid.org/0000-0002-7536-7937
Sergey V. Semochkin, MD, head of the group of high-dose chemotherapy and bone marrow transplantation of P.A. Herzen Moscow Scientific Research Institute of Oncology – a branch of National Medical Research Center for Radiology of the Ministry of Healthcare of Russia, professor of the Department of oncology, hematology and radiation therapy of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 125284, Moscow, 3 2nd Botkinsky Drive. E-mail: semochkin_sv@rsmu.ru.
ORCID: https://orcid.org/0000-0002-8129-8114
Olga O. Chernysheva, 6th year student of the Faculty of general medicine, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: chernishevaoo@mail.ru. ORCID: https://orcid.org/0000-0003-4712-1240
Natalya B. Shakhrai, PhD in Medical Sciences, associate professor of the Department of therapy and preventive medicine, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: nholodkova@mail.ru. ORCID:
https://orcid.org/0000-0002-4223-1064


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