Русский
Cognitive disorders in patients during the acute period of coronavirus infection complicated by pneumonia and during the acute period of ischemic stroke: Similarities and differences
DOI: https://dx.doi.org/10.18565/therapy.2023.5.45-50
Kabysh S.S., Prokopenko S.V., Abdullayev M.B.
1) Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia; 2) I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital No. 20; 3) Federal Research and Clinical Center of FMBA of Russia, Krasnoyarsk
The aim: to estimate the cognitive status and dynamics of CD in patients with a novel coronavirus infection complicated by pneumonia and in patients in the acute period of ischemic stroke.
Material and methods. The study included three groups of patients: groups 1 and 2 – patients in the acute period of COVID-19 complicated by pneumonia (in different time periods of observation), group 3 – patients in the acute period of hemispheric ischemic stroke. Neuropsychological status of the participants was assessed using the MMSE, MoCA, FAB scales, and clock drawing test. The evaluation of the emotional-volitional sphere was carried out according to the HADS scale.
Results. CDs were found in all three study groups. In group 1, comparatively with group 2, there were more expressed disorders according to the neuropsychological scales MMSE, MoCA and FAB (p <0,001) data. In addition, upon admission to the hospital in group 1, there were more severe disorders of cognitive functions according to MMSE relatively to group 3 (p=0,001). When comparing the cognitive status in groups 2 and 3 at admission, patients in group 3 had worse scores in MMSE (p <0,001), MoCA (p <0,001) and FAB (p <0,001). When assessing the dynamics of CD in all three groups, a statistically significant tendency towards their improvement was only in group 3 (p <0,001).
Conclusion. CD was detected in all the studied groups, with the most expressed disorders observed in group 1. When analyzing cognitive functions condition in group 3, there was a tendency for their recovery as the acute period of stroke was going on, which was not observed in groups 1 and 2.
Literature
1. Zhao Q., Wang X., Wang T. et al. Cognitive rehabilitation interventions after stroke: Protocol for a systematic review and meta-analysis of randomized controlled trials. Syst Rev. 2021; 10(1): 66. https://dx.doi.org/10.1186/s13643-021-01607-7. 2. Hartung T.J., Neumann C., Bahmer T. et al. Fatigue and cognitive impairment after COVID-19: A prospective multicentre study. EClinicalMedicine. 2022; 53: 101651. https://dx.doi.org/10.1016/j.eclinm.2022.101651. 3. Solaro C., Gamberini G., Masuccio F.G. Cognitive impairment in young COVID-19 patients: the tip of the iceberg? Neurol Sci. 2021; 42(12): 4865–66. https://dx.doi.org/10.1007/s10072-021-05534-2. 4. Rass V., Beer R., Schiefecker A.J. et al. Neurological outcomes 1 year after COVID-19 diagnosis: A prospective longitudinal cohort study. Eur J Neurol. 2022; 29(6): 1685–96. https://dx.doi.org/10.1111/ene.15307. 5. Парфенов В.А. Когнитивные нарушения после инсульта. Неврология, нейропсихиатрия, психосоматика. 2019; 11(4): 22–27. [Parfenov V.A. Poststroke cognitive impairment. Nevrologiya, neyropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2019; 11(4): 22–27 (In Russ.)]. https://dx.doi.org/10.14412/2074-2711-2019-4-22-27. EDN: RKWRPI. 6. Frantellizzi V., Pani A., Ricci M. et al. Neuroimaging in vascular cognitive impairment and dementia: A systematic review. J Alzheimers Dis. 2020; 73(4): 1279–94. https://dx.doi.org/10.3233/jad-191046. 7. Solaro C., Gamberini G., Masuccio F.G. Cognitive impairment in young COVID-19 patients: the tip of the iceberg? Neurol Sci. 2021; 42(12): 4865–66. https://dx.doi.org/10.1007/s10072-021-05534-2. 8. Головачева В.А., Табеева Г.Р., Кузнецов И.В. Когнитивные нарушения при covid-19: взаимосвязь, патогенез и вопросы терапии. Неврология, нейропсихиатрия, психосоматика. 2021; 13(2): 123–129. [Golovacheva V.A., Tabeeva G.R., Kuznetsov I.V. Cognitive impairment in COVID-19: associations, pathogenesis and treatment questions. Nevrologiya, neyropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2021; 13(2): 123–129 (In Russ.)]. https://dx.doi.org/10.14412/2074-2711-2021-2-123-129. EDN: ZYCCMG. 9. Qin Y., Wu J., Chen T. et al. Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations. J Clin Invest. 2021; 131(8): e147329. https://dx.doi.org/10.1172/JCI147329. 10. Кабыш С.С., Прокопенко С.В., Абдуллаев М.Б. с соавт. Состояние когнитивных функций при инфекции COVID-19, осложненной вирусной пневмонией, у пациентов молодого и среднего возраста в период 2020–2022 гг. Неврологический вестник. 2022; 54(4): 14–21. [Kabysh S.S., Prokopenko S.V., Abdullaev M.B. et al. The state of cognitive functions in COVID-19 complicated by viral pneumonia in young and middle-aged patients in the period 2020–2022. Nevrologicheskiy vestnik = Neurology Bulletin. 2022; 54(4): 14–21 (In Russ.)]. https://dx.doi.org/10.17816/nb112460. EDN: UMYRZC. 11. Дементьева О.В., Старикова Н.Л. Динамика нейропсихологического статуса пациентов в остром периоде ишемического инсульта. Казанский медицинский журнал. 2015; 96(6): 1061–1065. [Dementeva O.V., Starikova N.L. Neurological and psychological status in acute stage of ischemic stroke. Kazanskiy meditsinskiy zhurnal = Kazan Medical Journal. 2015; 96(6): 1061–1065 (In Russ.)]. https://dx.doi.org/10.17750/KMJ2015-1061. EDN: UYACOJ. 12. Козелкин А.А., Кузнецов А.А., Новикова Л.В. Особенности и динамика когнитивных нарушений у больных первичным и повторным мозговым ишемическим полушарным инсультом. Запорожский государственный медицинский университет. 2014; (4): 56–59. [Kozelkin A.A., Kuznetsov A.A., Novikova L.V. Characteristics and dynamics of cognitive impairment in patients with primary and recurrent cerebral ischemic hemispheric stroke. Zaporozhskiy gosudarstvennyy meditsinskiy universitet = Zaporozhye Medical Journal. 2014; (4): 56–59 (in Russ.)]. EDN: SSZQRZ. 13. Прокопенко С. В., Можейко Е.Ю., Левин О.С. с соавт. Когнитивные нарушения и их коррекция в остром периоде ишемического инсульта. Журнал неврологии и психиатрии им. С.С. Корсакова. 2012; 112(8–2): 35–39. [Prokopenko S.V., Mozheyko E.Yu., Levin O.S. et al. Cognitive disorders and its correction in the acute period of ischemic stroke. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry. 2012; 112(8–2): 35–39 (in Russ.)]. EDN: PYWVIJ. 14. Beyrouti R., Adams M.E., Benjamin L. et al. Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry. 2020; 91(8): 889–91. https://dx.doi.org/10.1136/jnnp-2020-323586. 15. Poyiadji N., Shahin G., Noujaim D. et al. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: Imaging features. Radiology. 2020; 296(2): E119–20. https://dx.doi.org/10.1148/radiol.2020201187 16. AlKetbi R., AlNuaimi D., AlMulla M. et al. Acute myelitis as a neurological complication of COVID-19: A case report and MRI findings. Radiol Case Rep. 2020; 15(9): 1591–95. https://dx.doi.org/10.1016/j.radcr.2020.06.001.a
About the Autors
Sergey S. Kabysh, assistant at the Department of physical and rehabilitation medicine, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia. Address: 660022, Krasnoyarsk, 1 Partizana Zheleznyaka Str. E-mail: sergioowl@yandex.ru. ORCID: https://orcid.org/0000-0002-9029-4553
Semyon V. Prokopenko, MD, professor, head of the Department of nervous diseases with a course of postgraduate study, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia. Address: 660022, Krasnoyarsk, 1 Partizana Zheleznyaka Str. E-mail: s.v.proc.58@mail.ru.
ORCID: https://orcid.org/0000-0002-4778-2586
Murad B. oglu Abdullaev, resident of the Department of nervous diseases with a course of postgraduate study, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia. Address: 660022, Krasnoyarsk, 1 Partizana Zheleznyaka Str.
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