Cognitive disorders in patients during the acute period of coronavirus infection complicated by pneumonia and during the acute period of ischemic stroke: Similarities and differences


DOI: https://dx.doi.org/10.18565/therapy.2023.5.45-50

Kabysh S.S., Prokopenko S.V., Abdullayev M.B.

1) Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia; 2) I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital No. 20; 3) Federal Research and Clinical Center of FMBA of Russia, Krasnoyarsk
Abstract. Cognitive disorders (CD) in ischemic stroke patients are formed in the acute period of the disease and become a significant problem in latest periods. CD development is also one of the possible consequences of COVID-19.
The aim: to estimate the cognitive status and dynamics of CD in patients with a novel coronavirus infection complicated by pneumonia and in patients in the acute period of ischemic stroke.
Material and methods. The study included three groups of patients: groups 1 and 2 – patients in the acute period of COVID-19 complicated by pneumonia (in different time periods of observation), group 3 – patients in the acute period of hemispheric ischemic stroke. Neuropsychological status of the participants was assessed using the MMSE, MoCA, FAB scales, and clock drawing test. The evaluation of the emotional-volitional sphere was carried out according to the HADS scale.
Results. CDs were found in all three study groups. In group 1, comparatively with group 2, there were more expressed disorders according to the neuropsychological scales MMSE, MoCA and FAB (p <0,001) data. In addition, upon admission to the hospital in group 1, there were more severe disorders of cognitive functions according to MMSE relatively to group 3 (p=0,001). When comparing the cognitive status in groups 2 and 3 at admission, patients in group 3 had worse scores in MMSE (p <0,001), MoCA (p <0,001) and FAB (p <0,001). When assessing the dynamics of CD in all three groups, a statistically significant tendency towards their improvement was only in group 3 (p <0,001).
Conclusion. CD was detected in all the studied groups, with the most expressed disorders observed in group 1. When analyzing cognitive functions condition in group 3, there was a tendency for their recovery as the acute period of stroke was going on, which was not observed in groups 1 and 2.
Keywords: post-stroke cognitive disorders, pandemic, COVID-19, coronavirus infection, cognitive disorders, stroke
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About the Autors

Sergey S. Kabysh, assistant at the Department of physical and rehabilitation medicine, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia. Address: 660022, Krasnoyarsk, 1 Partizana Zheleznyaka Str. E-mail: sergioowl@yandex.ru. ORCID: https://orcid.org/0000-0002-9029-4553
Semyon V. Prokopenko, MD, professor, head of the Department of nervous diseases with a course of postgraduate study, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia. Address: 660022, Krasnoyarsk, 1 Partizana Zheleznyaka Str. E-mail: s.v.proc.58@mail.ru.
ORCID: https://orcid.org/0000-0002-4778-2586
Murad B. oglu Abdullaev, resident of the Department of nervous diseases with a course of postgraduate study, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia. Address: 660022, Krasnoyarsk, 1 Partizana Zheleznyaka Str.


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