Benign metastasising lung leuomyoma: Differential diagnosis and clinical observation


DOI: https://dx.doi.org/10.18565/therapy.2023.6.70-77

Samozhenova P.S., Malyavin A.G., Adasheva T.V., Chernyaev A.L., Samsonova M.V., Goruleva E.I.

1) A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia; 2) Research Institute of Pulmonology of FMBA of Russia, Moscow; 3) Research Institute of Human Morphology, Moscow; 4) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow; 5) A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow; 6) Hospital of the Centrosojuz of the Russian Federation, Moscow; 7) Moscow medical institute «REAVIZ»
Abstract. Benign metastatic leiomyoma (BML) of lungs is an extremely rare disease characterized by the growth of histologically benign uterine leiomyoma in lung tissue. Most often, this disease does not manifest itself clinically, which makes it difficult for its timely diagnosis and treatment. Usually pulmonary BML is detected incidentally during computer tomography of chest organs (CT of the chest) and, due to the lack of specific morphology, requires differential diagnosis with other pulmonary diseases, which also appear on chest CT with focal rounded formations (lyfangioleiomyomatosis, thoracic endometriosis, metastatic lung disease, etc.). Benign metastases of uterine leiomyoma in the lungs are usually found in female patients of reproductive age and, according to some studies, are estrogen-dependent, which in turn determines the tactics of their treatment. The diagnosis of pulmonary BML is confirmed by immunohistological analysis.
Keywords: thoracic endometriosis, lifangioleiomyomatosis, benign metastatic leiomyoma, metastases, uterine leiomyoma, differential diagnosis
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About the Autors

Polina S. Samozhenova, clinical resident of the Department of therapy and preventive medicine, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: samozhenowapolina@gmail.com
ORCID: https://orcid.org/0000-0002-8170-0863
Andrey G. Malyavin, MD, professor, professor of the Department of phthisiology and pulmonology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia, general secretary of RSMSIM, chief external expert-ulmonologist of the central federal district of the Ministry of Healthcare of Russia. 127473, Moscow, 20/1 Delegatskaya Str. E-mail: ovzair.ru@mail.ru
ORCID: https://orcid.org/0000-0002-6128-5914
Tatyana V. Adasheva, MD, professor, professor of the Department of therapy and preventive medicine, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: adashtv@mail.ru
ORCID: https://orcid.org/0000-0002-3763-8994
Andrey L. Chernyaev, MD, professor, head of the Department of fundamental pulmonology, Research Institute of Pulmonology of FMBA of Russia, leading researcher at Research Institute of Human Morphology, professor of the Department of pathological anatomy and clinical pathological anatomy of the faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 115682, Moscow, 28 Orekhovy Boulevard. E-mail: cheral12@gmail.com
ORCID: https://orcid.org/0000-0003-0973-9250
Maria V. Samsonova, MD, head of the Laboratory of pathological anatomy, Research Institute of Pulmonology of FMBA of Russia. Address: 115682, Moscow, 28 Orekhovy Boulevard. E-mail: samary@mail.ru
ORCID: https://orcid.org/0000-0001-8170-1260
Ekaterina I. Goruleva, PhD in Medical Sciences, associate professor of the Department of internal diseases, Moscow medical institute «REAVIZ», head of the Department of therapy of the Hospital of the Centrosojuz of the Russian Federation. Address: 107150, Moscow, 39 Losinoostrovskaya Str. E-mail: ekaterina.gorulyova@gmail.com
ORCID: https://orcid.org/0000-0002-7536-7937


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