Systemic lupus erythematosus and lymphadenopathy in a young male patient


DOI: https://dx.doi.org/10.18565/therapy.2024.9.147-151

Bulanova N.A., Panchenkova L.A., Khamidova Kh.A., Ulyanova E.A., Ivanova S.M., Ryzhkova K.A., Khomyakova T.D., Popov V.V.

1) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow; 2) G.R. Derzhavin Tambov State University; 3) Russian University of Medicine of the Ministry of Healthcare of Russia, Moscow; 4) N.A. Semashko Clinical Hospital “RZhD-Medicine”, Moscow; 5) Medical Institute of Continuous Education of Moscow State University of Food Production
Abstract. Systemic lupus erythematosus is a systemic autoimmune disease of unknown etiology that develops in genetically predisposed patients under the influence of numerous external factors. A clinical case of systemic lupus erythematosus in 31-year-old male patient with the development of splenomegaly, lymphadenopathy, and lupus nephritis is described in the article. At the outpatient stage, the clinical picture was represented by periodic fever and articular syndrome in the form of polyarthralgia and volatile arthritis. Introduced case was particular because of the need to exclude lymphoproliferative disease in a patient with significant immunological indexes (ANF HEp2, ANA screen, ENA-screen, antibodies to dsDNA, C3, C4) due to severe lymphadenopathy. Diagnosis of lymphoproliferative disease was excluded after lymph node biopsy.
Keywords: lymphadenopathy, male gender, articular syndrome, differential diagnosis, systemic lupus erythematosus, lupus nephritis
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About the Autors

Natalia A. Bulanova, MD, Dr. Sci. (Medicine), associate professor of the Department of therapy, general medical practice and nuclear medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, professor of the Department of hospital therapy, G.R. Derzhavin Tambov State University. Address: 117997, Moscow, 1 Ostrovityanova St.
E-mail: bulanovanatalia@mtu-net.ru
Lyudmila A. Panchenkova, MD, Dr. Sci. (Medicine), professor of the Department of hospital therapy No. 1, Russian University of Medicine of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya St.
E-mail: lapanchenkova@mail.ru
Khadizhat A. Khamidova, MD, PhD (Medicine), associate professor of the Department of hospital therapy No. 1, Russian University of Medicine of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya St.
E-mail: k.khamidova@mail.ru
Elena A. Ulyanova, MD, PhD (Medicine), associate professor of the Department of hospital therapy No. 1, Russian University of Medicine of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya St.
E-mail: klepa13@list.ru
Svetlana M. Ivanova, MD, PhD (Medicine), head of the rheumatology center, N.A. Semashko Clinical Hospital “RZhD-Medicine”. Address: 109386, Moscow, 23/1 Stavropolskaya St.
E-mail: ivanova.revm@mail.ru
Kristina A. Ryzhkova, MD, rheumatologist at N.A. Semashko Clinical Hospital “RZhD-Medicine”. Address: 109386, Moscow, 23/1 Stavropolskaya St.
E-mail: Sedunova@mail.ru
Tatiana D. Khomyakova, MD, chief physician of N.A. Semashko Clinical Hospital “RZhD-Medicine”. Address: 109386, Moscow, 23/1 Stavropolskaya St.
E-mail: info@semashko.com
Vladimir V. Popov, MD, Dr. Sci. (Medicine), clinical pharmacologist at N.A. Semashko clinical hospital “RZhD- Medicine”, professor of the Department of pharmacy, Medical Institute of Continuous Education of Moscow State University of Food Production. Address: 109386, Moscow, 23/1 Stavropolskaya St.
E-mail: clinpharmcb6@mail.ru


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