Clinical and demographic characteristics of 256 patients with systemic lupus erythematosus in the Republic of Tatarstan
DOI: https://dx.doi.org/10.18565/therapy.2020.2.54-61
Ismagilova R.R., Maksudova A.N., Mitrofanova E.I.
1 Kazan State Medical University of the Ministry of Healthcare of Russia;
2 Republican clinical hospital of the Ministry of Healthcare of the Republic of Tatarstan, Kazan
Purpose: to study demographic, epidemiological and clinical data of patients with systemic lupus erythematosus (SLE) in the Republic of Tatarstan.
Material and methods. A retrospective study of inpatient records of patients with SLE treated in the nephrological and rheumatology Department of the Republican clinical hospital of Kazan from 2004 to 2018 was conducted. 1598 inpatient records were studied.
Results. The study group included 256 patients with SLE: 230 women, 26 men. The age at diagnosis of SLE in women was 30,0 [23,0; 41,0] years, in men 25,5 [18,0; 37,0] years. One of the most frequent manifestations of SLE was the defeat of the musculoskeletal system, the defeat of the skin and mucous membranes and VN. 5-, 10 -, 15-year survival of patients in our group was 93,7%, 90,8% and 86,4%, respectively.
Conclusion. The population of patients with SLE in the Republic of Tatarstan was dominated by women with a peak incidence of 29,0 [21,0; 38,0] years. The frequency of clinical manifestations and survival of patients in the study group correspond to the results of other authors.
Literature
- Клюквина Н.Г. Системная красная волчанка: вопросы диагностики и ведения больных. ДОКТОР.РУ. 2013; 2(80): 44–50. [Klyukvina N.G. Systemic lupus erythematosus: issues of patients diagnostics and management. DOCTOR.RU. 2013; 2(80): 44–50 (In Russ.)].
- Сигидин Я.А., Гусева Н.Г., Иванова М.М. Диффузные болезни соединительной ткани: руководство для врачей. М. 1994; 250 с.[Sigidin Ya.A., Guseva N.G., Ivanova M.M. Diffuse connective tissue diseases: Guide for physicians. M. 1994; 250 p. (In Russ.)].
- Mok C.C., Lee K.W., Ho C.T. A prospective study of survival and prognostic indicators of systemic lupus erythematosus in a southern Chinese population. Rheumatology (Oxford). 2000; 39(4): 399–406.
- Шадуро Д.В. Системная красная волчанка: иммунный статус, эндотоксинсвязывающие факторы и эпидемиологические особенности в Республике Крым: дис. … канд. мед. наук: 14.03.09 – Москва. 2017; 150 с. [Shaduro D.V. Systemic lupus erythematosus: immune status, endotoxin-binding factors and epidemiological features in Crimea. Dissertation for the degree of candidate of medical sciences: 14.03.09 – Moscow. 2017; 150 p. (In Russ.)].
- Hadidi K.T., Medhat B.M., Abdel Baki N.M. Characteristics of systemic lupus erythematosus in a sample of the Egyptian population: a retrospective cohort of 1109 patients from a single center. Lupus. 2018; 27(6): 1030–38. doi: 10.1177/0961203317751856
- Cervera R., Khamashta M.A. Morbidity and mortality in systemic lupus erythematosus. A multicenter prospective study of 1,000 patients. Medicine (Baltimore). 1999; 78(3): 167–75.
- Cervera R., Khamashta M.A., Hughes G.R.V. The Euro-lupus project: epidemiology of systemic lupus erythematosus in Europe. Lupus. 2009; 18: 869–74. doi: 10.1177/0961203309106831
- Cervera R., Munther Khamashta. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1000 patients. Medicine. 2003; 82(5): 299–308.
- Оттева Э.Н. Современное течение и лечение системной красной волчанки (по материалам Хабаровского края): дис. … канд. мед. наук: 14.00.39 – Москва. 2002; 202 с. [Otteva E.N. Modern course and treatment of systemic lupus erythematosus (on materials of Khabarovsky krai). Dissertation for the degree of candidate of medical sciences: 14.00.39 – Moscow. 2002; 202 p. (In Russ.)].
- Tan E.M., Cohen A.S. et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthr. Rheum. 1982; 25(11): 1271–77.
- Hochberg M.C. Updating the American College of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997; 40(9): 1725.
- Leuchten N., Milke B., Winkler-Rohlfing B. Early symptoms of systemic lupus erythematosus (SLE) recalled by 339 SLE patients. Lupus. 2018; 27(9): 1431–36. doi: 10.1177/0961203318776093
- Ng R., Bernatsky S., Rahme E. Disease characterization of systemic lupus erythematosus (SLE) patients in Quebec. Lupus. 2017; 26(9): 1005–11. doi: 10.1177/0961203317692435
- Mahmoud G.A., Shahin A.A., Zayed H.S, Moghazy A. Clinical and immunological pattern and outcome of Egyptian systemic lupus erythematosus patients: a single center experience. Lupus. 2018; 27(9): 1562–69. doi: 10.1177/0961203318776085
- Houman M.H., Smiti-Khanfir M., Ben Ghorbell I., Miled M. Systemic lupus erythematosus in Tunisia demographic and clinical analysis of 100 patients. Lupus. 2004; 13(3): 204–11.
- Ребров А.П., Оксеньчук А.Н. Встречаемость хронической болезни почек и ее структура у больных системной красной волчанкой. Современные проблемы науки и образования. 2013; 3: 130–136. [Rebrov A.P., Oksenchuk A.N. Occurrence and structure of chronic kidney disease in patients with systemic lupus erythematosus. Sovremennye problemy nauki i obrazovaniya. 2013; 3: 130–136 (In Russ.)].
- Bernardo Pons-Estel. The GLADEL Multinational Latin American prospective inception cohort of 1214 patients with systemic lupus erythematosus. Medicine. 2004; 83(1): 1–17.
- Койлубаева Г.М., Асеева Е.А. с соавт. Клинические проявления, варианты течения и исходы системной красной волчанки у жителей Кыргызстана. Научно-практическая ревматология. 2016; 54(4): 432–441. [Koilubaeva G.M., Aseeva E.A., Solovyev S.K. et. al. Clinical manifestations, courses, and outcomes of systemic lupus erythematosus in the dwellers of Kyrgyzstan. Nauchno-prakticheskaya revmatologiya. 2016; 54(4): 432–441 (In Russ.)]. doi: 10.14412/1995-4484-2016-432-441.
- Cansu D.U., Teke H.U. Survival analysis of Turkish patients with systemic lupus erythematosus: older age at diagnosis affects mortality. Archives of Rheumatology. 2017; 32(2): 141–48. doi: 10.5606/ArchRheumatol.2017.6173.
- Akbarian M., Faezi S.T., Gharibdoost F. Systemic lupus erythematosus in Iran: a study of 2280 patients over 33 years. International journal of rheumatic disease. 2010; 13(4): 374–79. doi: 10.1111/j.1756-185X.2010.01547.x
- Al Arfaj A.S., Khalil N. Clinical and immunological manifestations in 624 SLE patients in Saudi Arabia. Lupus. 2009; 18(5): 465–73. doi: 10.1177/0961203308100660.
- Blanco F.J., Gomez-Reino J.J. Survival analysis of 306 European Spanish patients with systemic lupus erythematosus. Lupus. 1998; 7(3): 159–63.
- Maloney K.C., Ferguson T.S. Clinical and immunological characteristics of 150 systemic lupus erythematosus patients in Jamaica: a comparative analysis. Lupus. 2017; 26(13): 1448–56. doi: 10.1177/0961203317707828.
- Sebastiani G.D., Prevete I. Early Lupus Project: one-year follow-up of an Italian cohort of patients with systemic lupus erythematosus of recent onset. Lupus. 2018; 27(9): 1479–88. doi: 10.1177/0961203318777112
- Sheng Chen, Yue-Ying G.U. An 18-year follow-up study of a lupus cohort in Shanghai. APLAR Journal of Rheumatology. 2006; 9(4): 327–30.
- Асеева Е.А., Дубиков А.И., Левашева Л.А, Койлубаева Г.М., Джетыбаева М.К., Эралиева В.Т., Каримова Э.Р., Исаева Б.Г., Калыкова М.Б., Сапарбаева М.М., Исаева С.М., Омарбекова Ж.И., Соловьева Е.С., Решетняк Т.М., Клюквина Н.Г., Попкова Т.В., Кошелева Н.М., Лисицына Т.А, Панафидина Т.А., Герасимова Е.В., Середавкина Н.В., Кондратьева Л.В., Матьянова Е.В., Цанян М.Э., Меснякина А.А., Летунович М.В., Лопатина Н.Е., Никишина Н.Ю., Федина Т.П., Сажина Е.Г., Глухова С.И., Соловьев С.К., Насонов Е.Л. Регистр пациентов с системной красной волчанкой, Евразийская когорта (Ренессанс). Научно-практическая ревматология. 2016; 54(5): 520–526. [Aseeva E.A. et al. The registry of systemic lupus erythematosus patients, a Eurasian cohort (RENAISSANCE). Nauchno-prakticheskaya revmatologiya. 2016; 54(5): 520–526 (In Russ)]. doi: https://doi.org/10.14412/1995-4484-2016-520-526.
- Алексеева Е.И., Дворяковская Т.М., Никишина И.П., Денисова Р.В., Подчерняева Н.С., Сухоруких О.А., Шубина Л.С. Системная красная волчанка: клинические рекомендации. Часть 1. Вопросы современной педиатрии. 2018; 17(1): 19–37. [Alekseeva E.I. et al. Systemic lupus erythematosus: clinical recommendations. Part 1. Voprosy sovremennoy pediatrii. 2018; 17(1): 19–37 (In Russ)]. doi: https://doi.org/10.15690/vsp.v17i1.1853.
- Harvey A.M., Shulman L.E., Tumulty P.A. Systemic lupus erythematosus: rewiew of the literature and clinical analysis of 138 cases. Medicine. 1954; 33(4): 291–437.
- Merrell M., Shulman L.E., Determination of prognosis in chronic disease, illustrated by systemic lupus erythematosus. 1955; 1(1): 12–32.
- Swaak A.J.G., Bronsveld W. Systemic lupus erythematosus. I Outcome and survival: Dutch experience with 110 patient studied prospectively. Annals of the rheumatic disease. 1989; 48: 447–54.
- Abu-Shakra M., Urowitz M.B. Mortality studies in systemic lupus erythematosus. Results from a single centre. I Causes of death. The Journal of rheumatology. 1995; 22: 1259–64.
- Jacobsen S., Petersn J. Mortality and causes of death in 513 Danish patients with systemic lupus rythematosus. Scandian Journal of Rheumtology. 1999. 28(2): 75–80.
- Карпенко Ю.Ю. Патология внутренних органов при поздней стадии системной красной волчанки (по данным регионального регистра): дис. … канд. мед. наук: 14.00.05 – Воронеж. 2008; 129 с. [Karpenko Yu.Yu. Pathology of internal organs at a late stage of systemic lupus erythematosus (according to the Regional Register). Dissertation for the degree of candidate of medical sciences: 14.00.05 – Voronezh. 2008; 129 p. (In Russ.)].
- Клюквина Н.Г., Насонов Е.Л. Выживаемость мужчин, страдающих СКВ. Научно-практическая ревматология. 2009; 6: 46–51. [Klyukvina N.G., Nasonov E.L. Survival of men with systemic lupus erythematosus. Nauchno-prakticheskaya revmatologiya. 2009; 6: 46–51 (In Russ.)].
- Mu L., Hao Y., Fan Y. Mortality and prognostic factors in Chinese patients with systemic lupus erythematosus. Lupus. 2018; 27(10): 1742–52. doi: 10.1177/0961203318789788.
About the Autors
Rezida R. Ismagilova, postgraduate student of the Department of hospital therapy of Kazan State Medical University of the Ministry of Healthcare of Russia. Address: 420012, Kazan, 49 Butlerova Str. Tel.: +7 (917) 884-80-68. E-mail: saifullina_rezid@mail.ru
Adelya N. Maksudova, MD, professor of the Department of hospital therapy of Kazan State Medical University of the Ministry of Healthcare of Russia. Address: 420012, Kazan, 49 Butlerova Str. Tel.: +7 (843) 236-77-44. E-mail: adelyamaksudova@gmail.com
Elena I. Mitrofanova, nephrologist of Republican clinical hospital of the Ministry of Healthcare of the Republic of Tatarstan. Address: 420064, Kazan, 138 Orenburg tract.
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