COVID-19 pandemic and the state of kidney function


DOI: https://dx.doi.org/10.18565/therapy.2023.7.72-80

Abysov A.S., Kichigin V.A., Savvateeva O.A.

1) I.N. Ulyanov Chuvash State University, Cheboksary; 2) I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Abstract. Currently it is fixed, that in case of COVID-19, along with the lung damage, there is coming the disorder of many other organs’ function, including kidneys.
The aim: to study the renal function condition in COVID-19 patients and its connection with the outcome of the disease.
Material and methods. 182 patients hospitalized in Emergency Care Hospital (Cheboksary) in 2021 with a confirmed COVID-19 diagnosis were included in the study by the randomized methodic.
Results. Chronic kidney disease (CKD) was registered in 52,7% persons, acute kidney damage (AKD) – in 17,6%. In case of AKD the proportion of patients in oxygen therapy (84,4 vs 58%; p =0,005) was higher, it was more commonly required an IVL (87,5 vs 31,5%; p <0,001). The mortality from COVID-19 in individuals without AKD was 35,3%, with AKD – 90,6% (p <0,001). Among patients with CKD, patients with concomitant pathology, in particular, arterial hypertension, CHD, diabetes, were more common. In patients with CKD, higher rates of the scores on the NEWS 2 scale and lower levels of oxygen saturation from the 3rd day of hospitalization were fixed. The mortality in the group without CKD reached 33,7%, with CKD – 52,7% (p=0,004). Charlson’s Comorbide Index was expected to be higher in patients with CKD – 6,5 against 4 points in patients without CKD (p <0,001). In a group with a high comorbidity, the mortality of patients without CKD was 75,9%, with CKD - 73.0% (p=0,773), and in a group with a low comorbidity – 13,8 and 30%, respectively (p=0,050).
Conclusion. COVID-19 can also have an extrapulmonary course, including causing or exacerbating kidney disease. Persons with CKD and/or AKD and COVID-19 are characterized by more severe manifestations of the disease and higher mortality. Studies of risk factors for poor outcomes will allow to perform more effective treatment of patients having impaired renal function and COVID-19.
Keywords: Charlson Comorbidity Index, COVID-19, chronic kidney disease, acute kidney injury
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About the Autors

Aleksey S. Abyzov, assistant at the Department of faculty and hospital therapy, I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Avenue. E-mail: medikchuvsu@yandex.ru.
ORCID: https://orcid.org/0000-0002-3770-9414
Vadim A. Kichigin, PhD in Medical Sciences, associate professor, associate professor of the Department of faculty and hospital therapy, I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Avenue. E-mail: vadim-kichigin@mail.ru. ORCID: https://orcid.org/0000-0002-9161-2066
Olga A. Savvateeva, PhD in Medical Sciences, physician at the medical and diagnostical Department of the Sechenov Center for Motherhood and Childhood, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str.
E-mail: olya-benda@mail.ru. ORCID: https://orcid.org/0000-0003-4919-9332


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