The use of Alflutop® in real clinical practice: Results of a multicenter prospective observational study


DOI: https://dx.doi.org/10.18565/therapy.2023.7.90-101

Lila A.M., Strebkova E.A., Alekseeva L.I., Taskina E.A., Kashevarova N.G.

1) V.A. Nasonova Research Institute of Rheumatology, Moscow; 2) Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia, Moscow
Abstract. The osteoarthritis localization – an important aspect in the personalized therapy.
Purpose: to study the effectiveness of the Alflutop® in patients with OA of different localization and/ or lower back pain (LBP).
Material and methods. The observational prospective study involved 163 clinical centers from 58 regions of Russia. The study participants were 22,525 patients with OA of different localization and/or LBP. The duration of the study ranged from 20 to 31 days. Alflutop® was prescribed 1 ml intramuscularly (IM) daily No. 20 or 2 ml IM every other day No. 10. The effectiveness of treatment was determined by the following parameters: the time of the onset of the effect, the dynamics of the intensity of pain according to VAS, the assessment of the quality of life according to EQ-5D and the patient’s general health status (PGH) according to VAS.
Results. Against the background of therapy with Alflutop® in patients with OA of different localization and/or LBP, a significant symptomatic effect was noted. In patients with OA of small joints of the hands, the analgesic effect developed on the 9th [5; 10] day of therapy, while the intensity of pain in VAS decreased by 62,3%, the PGH improved by 28,6%. Similar results were obtained with other OA localizations. In patients with OA of the hip joints, knee joints, as well as with a generalized form, the rapidity of the effect was noted – on average on the 9th day of therapy, a significant decrease in the level of pain when moving in the joint, an improvement in the PGH (p <0,05) and quality of life parameters according to EQ-5D (p <0,05) compared with the initial indicators.
Conclusion. The results of a multicenter study demonstrated the effectiveness of Alflutop® in patients with OA of different localization. Significant clinical improvement was observed in more than 90% of the participants after 1 course of therapy. The use of Alflutop® in clinical practice is appropriate for the treatment of patients with local and generalized forms of OA.

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About the Autors


Alexander M. Lila, MD, professor, corresponding member of RAS, director of V.A. Nasonova Research Institute of Rheumatology, head of the Department of rheumatology, Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia. Address: 115522, Moscow, 34А Kashirskoe Highway.
E-mail: amlila@mail.ru. ORCID: https://orcid.org/0000-0002-6068-3080
Ekaterina A. Strebkova, PhD in Medical Sciences, researcher at the Laboratory of osteoarthritis of the Department of metabolic diseases of bone and joints, V.A. Nasonova Research Institute of Rheumatology. Address: 115522, Moscow, 34А Kashirskoe Highway. E-mail: dr.ekaterinastrebkova@yandex.ru. ORCID: https://orcid.org/0000-0001-8130-5081 Lyudmila I. Alekseeva, MD, head of the Department of metabolic diseases of bone and joints, V.A. Nasonova Research Institute of Rheumatology, professor of the Department of rheumatology, Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia. Адрес: 115522, Moscow, 34А Kashirskoe Highway.
ORCID: https://orcid.org/0000-0001-7017-0898
Elena A. Taskina, PhD in Medical Sciences, senior researcher at the Department of metabolic diseases of bone and joints, V.A. Nasonova Research Institute of Rheumatology. Address: 115522, Moscow, 34А Kashirskoe Highway.
ORCID: https://orcid.org/0000-0001-8218-3223
Natalya G. Kashevarova, PhD in Medical Sciences, researcher at the Department of metabolic diseases of bone and joints, V.A. Nasonova Research Institute of Rheumatology. Address: 115522, Moscow, 34А Kashirskoe Highway.
ORCID: https://orcid.org/0000-0001-8732-2720


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