New therapeutic opportunities of gastroprotection in cardiology


DOI: https://dx.doi.org/10.18565/therapy.2024.8.144-153

Golendyaeva P.I., Livzan M.A., Korennova O.Yu., Gaus O.V., Podolnaya S.P., Shkirinets A.V., Shukil L.V., Maltsev S.N.

1) Clinical Cardiology Dispensary, Omsk; 2) Omsk State Medical University of the Ministry of Healthcare of Russia; 3) Ministry of Healthcare of the Omsk Region, Omsk
Abstract. The successes achieved with additional effects on blood coagulation in the secondary prevention of atherothrombosis determine the widespread use of combination antithrombotic therapy among cardiac patients. However, this trend has not gone unnoticed in gastroenterological practice: antiplatelet agents and anticoagulants have taken leading positions as the main agents causing gastrointestinal complications. At the same time, currently existing clinical guidelines contain limited guidance on assessing hemorrhagic risks, and only proton pump inhibitors are considered as prophylactic drugs. The review is devoted to systematizing knowledge about the use of antithrombotic therapy a year after acute coronary syndrome from the standpoint of preventing bleeding from the upper gastrointestinal tract, taking into account the condition of the mucous membrane according to endoscopic examination, as well as modern gastroprotection opportunities.

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About the Autors


Polina I. Golendyaeva, MD, cardiologist at the Clinical Cardiology Dispensary (Omsk). Address: 644024, Omsk, 41 Lermontova St.
E-mail: polyaz-13_17@mail.ru
ORCID: https://orcid.org/0000-0001-6142-0832
Maria A. Livzan, MD, Dr. Sci (Medicine), professor, corresponding member of RAS, head of the Department of faculty therapy and gastroenterology, rector of Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: mlivzan@yandex.ru
ORCID: https://orcid.org/0000-0002-6581-7017
Olga Yu. Korennova, MD, Dr. Sci (Medicine), professor, professor of the Department of faculty therapy and gastroenterology, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: korennova@mail.ru
ORCID: https://orcid.org/0000-0001-8047-5521
Olga V. Gaus, MD, Dr. Sci (Medicine), associate professor, associate professor of the Department of faculty therapy and gastroenterology, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: gaus_olga@bk.ru
ORCID: https://orcid.org/0000-0001-9370-4768
Svetlana P. Podolnaya, MD, PhD (Medicine), deputy chief physician for outpatient and polyclinic work of Clinical Cardiology Dispensary (Omsk). Address: 644024, Omsk, 41 Lermontova St.
E-mail: podolnayasvetlana@mail.ru
ORCID: https://orcid.org/0000-0002-2059-7727
Anastasia V. Shkirinets, MD, PhD (Medicine), associate professor of the Department of propaedeutics of internal diseases, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: avnelidova@mail.ru
ORCID: https://orcid.org/0000-0003-0149-6119
Lyudmila V. Shukil, MD, PhD (Medicine), associate professor of the Department of pharmacology and clinical pharmacology, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: guomsk@yandex.ru
ORCID: https://orcid.org/0000-0002-1546-0734
Sergey N. Maltsev, MD, PhD (Medicine), Deputy Minister of Healthcare of the Omsk Region. Address: 644043, Omsk, 6 Krasny put’ St.
E-mail: maltsev@minzdrav.omskportal.ru
ORCID: https://orcid.org/0009-0006-9265-0423


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