Поражение почек, печени и скелетной мускулатуры у пациентов с сердечной недостаточностью с сохраненной фракцией выброса левого желудочка: независимые процессы или звенья одной цепи?


DOI: https://dx.doi.org/10.18565/therapy.2021.3.59-67

А.В. Пяцкая, О.Н. Джиоева, О.М. Драпкина

ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России, г. Москва
Аннотация. Больные сердечной недостаточностью с сохраненной фракцией выброса мультиморбидны и фенотипически разнородны. Достаточно часто у них встречается поражение почек, печени и скелетной мускулатуры. В независимых на первый взгляд процессах развития внесердечных заболеваний можно выявить общность предрасполагающих факторов, звеньев патогенеза и взаимосвязь с поражением сердца. Нарушение функции одного органа неизменно ведет к повреждению в другом, создавая замкнутый круг патологических событий.
Ключевые слова: сердечная недостаточность с сохраненной фракцией выброса, хроническая болезнь почек, неалкогольная жировая болезнь печени, саркопения, хроническое системное воспаление, эндотелиальная дисфункция
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Об авторах / Для корреспонденции

Алина Валерьевна Пяцкая, аспирант лаборатории фундаментальных и прикладных аспектов ожирения ФГБУ «Нацио­нальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России. Адрес: 101000, г. Москва, Петроверигский пер., д. 10, стр. 3. Тел.: 8 (965) 362-15-83. E-mail: skorobogatova.al@gmail.com
Ольга Николаевна Джиоева, к.м.н., ст.н.с. лаборатории фундаментальных и прикладных аспектов ожирения ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России. Адрес: 101000, г. Москва, Петроверигский пер., д. 10, стр. 3.
Оксана Михайловна Драпкина, д.м.н., профессор, чл.-корр. РАН, директор ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России. Адрес: 101000, г. Москва, Петроверигский пер., д. 10, стр. 3. Тел.: (495) 623-86-36. E-mail: ODrapkina@gnicpm.ru. ORCID: 0000-0002-4453-8430

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