Sacubitril/valsartan – novel direction in heart failure treatment


Е.О. Taratukhin

FSBEI HE Russian National Research Medical University n.a. Pirogov N.I., Moscow
The article is focused on the novel drug for congestive heart failure management – combination of valsartan and sacubitril, that has recently became available on pharmaceutical market, and has been included in the European Guidelines due to proven efficacy and safety. In the article, natriuretic system is described and the place of neprilysin in it. Mechanism of sacubitril is presented and rationale for its combination with valsartan. The data from the main clinical trials is given, as some recent references on the drug clinical usage.
Keywords: sacubitril, neprilysin, angiotensin, congestive heart failure, renin, valsartan, cardiorenal syndrome
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    • About the Autors

    Evgeny O. Taratukhin, MD, PhD, M.A., Associate Professor at the Department of Internal Medicine, Pirogov Russian National Research Medical University. Address: 117997, Moscow, 1 Ostrovityanova St. Tel.: +74953751230.
    E-mail: cardio03@yandex.ru


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