The role of cartilaginous glycoprotein-39 in patients with knee osteoarthritis with concomitant coronary heart disease, arterial hypertension and dyslipidemia of unclear genesis - a multidisciplinary problem
A.A. Ktsoeva
Federal State Budgetary Educational Institution of Higher Education «North Osetian state medical academy of the Ministry of Healthcare of Russia», Vladikavkaz
Objective. Тo study the role of cartilage glycoprotein-39 in patients with gonarthrosis in combination with cardiac ischemia, arterial hypertension and dyslipidemia, depending on inflammatory changes in joints, radiographic stage, severity of pain syndrome and degree of functional insufficiency of the joints. Material and methods. 110 patients with gonarthrosis in combination with cardiac ischemia, arterial hypertension and dyslipidemia were included in the study in the rheumatological department of NOSMA. Clinical parameters of gonarthrosis were evaluated and the concentration of cartilage glycoprotein-39, CRP, ESR and lipid spectrum was measured in serum. Results. A significant increase of cartilage glycoprotein-39 was revealed in all OA patients. The highest level of cartilage glycoprotein-39 was revealed in patients with radiographic stage III, especially if there was a reactive synovitis. There was significant correlation between the cartilage glycoprotein-39 and clinical parameters of gonarthrosis, CRP, ESR, cholesterol, CA. Conclusion. Our study of the level of cartilage glycoprotein-39, CRP, lipid spectrum indicated the presence of an inflammatory process, which is an important part of the pathogenesis of osteoarthritis and atherosclerosis.
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About the Autors
Alina A. Ktzoeva, head of the receiving Department of SOGMA clinical hospital. Address: 362027, RSO-Alania, Vladikavkaz, 11 Titova Str. Tel. +78672280876. Е-mail: Kcoeva.alina.85@mail.ru
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