Atypical hemolytic-uremic syndrome: current view and case report


DOI: https://dx.doi.org/10.18565/therapy.2019.1.167-171

Malimon V.V., Kokorin V.A., Korsakova L.V., Grigoriev E.K., Gordeev I.G.

1 Pirogov Russian National Research Medical University, Moscow; 2 Municipal Clinical Hospital №15 named after O.M. Filatov, Moscow
This paper presents current approach on prevalence, etiology, pathogenesis, presentations, diagnosis and treatment of atypical hemolytic-uremic syndrome (aHUS). We also demonstrates the clinical case of the woman of 36 years after performing a procedure for separate diagnostic curettage of the uterus. The disease was accompanied by the development of fever, circulatory failure, gastrointestinal syndrome and acute renal damage. The uniqueness of this case lies in the extremely rare occurrence of aHUS in the population, as well as in the width of the differential-diagnostic search carried out. The crucial point in the diagnosis of the case presented was the determination of the main syndrome in the clinical picture of the disease - thrombotic microangiopathy (TMA).
Keywords: fresh frozen plasma, atypical hemolytic-uremic syndrome, thrombotic microangiopathy, anemia, acute kidney injury
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About the Autors

Valentin V. Malimon, MD, resident of the hospital therapy №1 Department of Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova str. E-mail: malimon.1993@mail.ru
Valentin A. Kokorin, MD, PhD, associate professor of the hospital therapy №1 Department of Pirogov Russian National research medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova str. Tel.: +7 (916) 132-96-06. E-mail: valentinkokorin@yahoo.com
Lubov V. Korsakova, MD, head of nephrology Department №21, Municipal clinical hospital №15 named after O.M. Filatov of Department of health of Moscow. Address: 111539, Moscow, 23 Veshnyakovskaya str.
Eugeny K. Grigoriev, MD, anesthesiologist-resuscitator of the intensive care №6 department, Municipal Clinical Hospital №15 named after O.M. Filatov of Department of Health of Moscow. Address: 111539, Moscow, 23 Veshnyakovskaya str.
Ivan G. Gordeev, MD, PhD, professor, head of the hospital therapy №1 Department of Pirogov Russian National research medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova str.
E-mail: cardio-15@yandex.ru


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