Troponin I and D-dimer in diagnostics of myocardial infarction


DOI: https://dx.doi.org/10.18565/therapy.2019.7.64-68

Kostrova O.Yu., Stomenskaya I.S., Timofeeva N.Yu., Struchko G.Yu., Bubnova N.V., Chesnokova A.E., Samushkina A.V.

I.N. Ulyanov Chuvashsky State University, Cheboksary
Until now, mortality from myocardial infarction is in the first place. At the same time, young people are suffering more and more. Recently, atypical forms of myocardial infarction have become more common, which, of course, complicates the diagnostics of the disease. In connection with the development of laboratory diagnostics, it became possible to determine the markers of myocardial infarction in blood, which increase regardless of the clinical manifestations of the disease. The value of tests increases in those cases when is difficult electrocardiographic diagnostics of the disease. The study revealed a direct correlation between ST-segment elevation, the presence of myocardial infarction complications, disease recurrence and increased in the level of troponin I in blood. The increase in the level of D-dimer was associated not only with myocardial infarction, but also with the presence of concomitant pathology and recent surgical interventions. The localization of myocardial lesions in the groups of men and women, accompanied by the highest rise in the concentration of troponin I and D-dimer, was determined.
Keywords: the ST-segment, cardiospecific troponin I, tests, localization of infarction, D-dimer, myocardial infarction
Read entire article

Literature

  1. Королева Л.Ю., Голицына Н.А., Носов В.П., Злобин М.В., Соболь Ю.Н., Гурвич Е.В. Высокочувствительный тропонин в диагностике инфаркта миокарда: реальная диагностическая ценность или переоцененные возможности? Медицинский альманах. 2017; 3(48); 161–168.

  2. Стручко Г.Ю., Стоменская И.С., Кострова О.Ю., Васильева С.О., Степанов В.Н., Степанова И.В. Маркеры некроза миокарда в зависимости от изменений сегмента ST у больных острым инфарктом миокарда. Вестник Чувашского университета. 2013; 3: 527–530.

  3. Тумаренко А.В., Скворцов В.В. Тропонины в диагностике инфаркта миокарда. Медицинский алфавит. 2013; 1(3): 12–14.

  4. Мухтаров Т.А., Скворцов В.В., Тумаренко А.В., Белякова Е.В. Современные биохимические маркеры в диагностике инфаркта миокарда. Медицинский алфавит. 2016; 2; 28 (291): 37–41.

  5. Скворцов В.В., Тумаренко А.В. Тропонины в диагностике инфаркта миокарда. Поликлиника. 2015; 2–1: 15–16.

  6. Белая И.Е., Коломиец В.И., Мусаева Э.К. Значимость лабораторных показателей в прогнозировании исходов острого инфаркта миокарда. Клиницист. 2017; 11(4–1): 29–35.

  7. Фурман Н.В., Пучиньян Н.Ф., Ансимова О.М., Довгалевский П.Я. Повышенный уровень Д-димера в плазме крови как маркер высокого риска артериальных тромбозов. Рациональная фармакотерапия в кардиологии. 2008; 4(4): 80–84.

  8. Cushman M., Lemaitre R.N., Kuller L.H. et al. Fibrinolytic activation markers predict myocardial infarction in the elderly. The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 1999; 19: 493–98.

  9. Yarnell J., McCrum E., Rumley A. et al. Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis Study. Eur Heart J. 2005; 26: 332–42.

  10. Миц Н.М., Зырянова Ю.М., Сташкевич Д.С. Особенности использования ранних кардиомаркеров в диагностике инфаркта миокарда. Вестник Челябинского государственного университета. 2015; 21(376): 123–127.

  11. Митьковская Н.П., Галицкая С.С., Губарь Е.Н., Добросольцева Н.А., Олихвер Ю.А. Маркеры воспаления и некроза, состояние системы гемостаза при неблагоприятном течении инфаркта миокарда у пациентов, подвергшихся чрескожным коронарным вмешательствам. Медицинские новости. 2016; 8: 61–64.

  12. Greenslade J.H., Carlton E.W., Van Hise C., Cho E., Hawkins T., Parsonage W.A., Tate J., Ungerer J., Cullen L. Diagnostic accuracy of a new high-sensitivity troponin I assay and five accelerated diagnostic pathways for ruling out acute myocardial infarction and acute coronary syndrome. Ann Emerg Med. 2018; 71(4): 439–51.e3. doi: 10.1016/j.annemergmed.2017.10.030.

  13. Sandoval Y., Smith S.W., Love S.A., Sexter A., Schulz K.&Apple F.S. (2017). Single high-sensitivity cardiac troponin i to rule out acute myocardial infarction. The American Journal of Medicine. 2017; 130(9): 1076–83.e1. doi: 10.1016/j.amjmed.2017.02.032.


About the Autors

Olga Yu. Kostrova, PhD, associate professor, associate professor of the Department of instrumental diagnostics with a course of phthisiology of I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Prospect Str. Tel.: +7 (961) 345-22-33. E-mail: evkbiz@yandeх.ru
Irina S. Stomenskaya, PhD, associate professor, associate professor of the Department of instrumental diagnostics with a course of phthisiology of I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Prospect Str. Tel.: +7 (917) 671-78-53. E-mail: irina.stomenskaja@gmail.com
Natalya Yu. Timofeeva, assistant of the Department of instrumental diagnostics with a course of phthisiology of the Department of instrumental diagnostics with a course of phthisiology of I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Prospect Str. Tel.: +7 (960) 303-14-00. E-mail: bla11blabla@yandex.ru
Gleb Yu. Struchko, MD, professor, head of the Department of instrumental diagnostics with a course of phthisiology of I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Prospect Str. Tel.: +7 (908) 309-87-37. E-mail: glebstr@mail.ru
Natalya V. Bubnova, assistant of the Department of instrumental diagnostics with a course of phthisiology of I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Prospect Str. Tel.: +7 (927) 863-05-35. E-mail: natalia210485@yandex.ru
Anastasia E. Chesnokova, resident physician of the 2nd year of study, speciality «Clinical laboratory diagnostics» of the Department of instrumental diagnostics with a course of phthisiology of I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Prospect Str. Tel.: +7 (917) 678-77-65. Email: Morgenstern2905@gmail.com
Anastasia V. Samushkina, clinical intern of the II year of study, resident physician of the 2nd year of study, speciality «Clinical laboratory diagnostics» of the Department of instrumental diagnostics with a course of phthisiology of I.N. Ulyanov Chuvash state university. Address: 428015, Cheboksary, 15 Moskovsky Prospect Str. Tel.: +7 (937) 370-53-75. E-mail: 11nastufa@mail.ru


Similar Articles

Back to Content

Бионика Медиа