Study of effectiveness of detoxing impact of the complex detox nutrition program on functional parameters of the organism


DOI: https://dx.doi.org/10.18565/therapy.2020.2.156-163

Pilat T.L., Bezrukavnikova L.M., Kolyaskina M.M., Bessonov V.V., Anvarul N.A., Khanferyan R.A.

1 Scientific Research Institute of labour medicine named after academician N.F. Izmerov, Moscow; 2 Federal Research Center of nutrition and biotechnology, Moscow; 3 Peoples’ Friendship University of Russia, Moscow
Adverse environmental factors, prolonged pharmacotherapy of chronic diseases, irradiation therapy, food contaminants, poor nutrition, smoking, alcohol intake and other factors are the cause of metabolic disorders. This leads to cumulation in the body of xeno- and endobiotics and their metabolites, leading to a chronicity of pathological processes, an aggravation of the course of diseases, and a deterioration in the quality of life of patients. To eliminate the resulting toxins, detoxification diet therapy is the most physiological and effective.
Purpose: to study the clinical effectiveness of the use of the Comprehensive nutrition program «DETOX», manufactured by LEOVIT Nutrio Ltd with the goal of detoxifying the organism.
Material and methods. A 15-day study involved 20 volunteers. To evaluate the effectiveness of the use of a comprehensive detoxification nutrition program, we used the developed «quality of life» questionnaire, organoleptic properties were assessed using 5 parameters (appearance, smell, color, taste, texture). We measured the dynamics of parameters of a clinical blood test (hemoglobin, leukocyte, erythrocyte levels, leukocyte counts), biochemical indicators of impaired liver function (AST, ALT, GGT, total bilirubin, direct bilirubin, urea, creatinine), the spectrum of blood lipids (concentration of total lipids and cholesterol) and fasting blood glucose. The concentration of lipid peroxidation products (LPO) was analyzed by spectrophotometric method.
Results. It was found that the DETOX comprehensive nutrition program significantly reduces the level of LPO, normalizes creatinine, urea, and liver enzymes (AST, ALT, GGT) in the blood, lowers ESR, glucose and cholesterol, improves skin barrier functions, has favorable organoleptic qualities and does not cause unwanted adverse reactions, including allergic ones.
Conclusion. Studies of the clinical efficacy of the use of the DETOX comprehensive nutritional program showed that the products included in the program have pronounced detoxifying agents, improving the functions of the main organs and systems involved in the metabolism of xenobiotics and endotoxins, which is confirmed by pronounced hepatoprotective, antioxidant, hypocholesterolemic effects.
Keywords: diet products, detoxification program, specialized foods, detoxification, antioxidants
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About the Autors

Tatiana L. Pilat, MD, leading researcher of Scientific Research Institute of labour medicine named after academician N.F. Izmerov. Address: 105275, Moscow, 31 Budennogo Prospect. Tel.: +7 (495) 366-06-09; +7 (495) 663-35-96. E-mail: tpilat@leovit.ru. ORCID: 0000-0002-5930-8849
Lyudmila M. Bezrukavnikova, PhD, leading researcher of medico-biological research laboratory of Scientific Research Institute of labour medicine named after academician N.F. Izmerov. Address: 105275, Moscow, 31 Budennogo Prospect. Tel.: +7 (495) 365-59-41. E-mail: bezrukavnikovalm@mail.ru. ORCID: 0000-0002-0430-4154
Maria M. Kolyaskina, PhD, Senior researcher of medico-biological research laboratory of Scientific Research Institute of labour medicine named after academician N.F. Izmerov, lecturer of the Department of labour medicine, aviation, space and diving medicine of I.M. Sechenov First Moscow State medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 105275, Moscow, 31 Budennogo Prospect. Tel.: +7 (495) 365-59-41.
E-mail: koliaskina.mm@irioh.ru. ORCID: 0000-0001-5356-1598
Vladimir V. Bessonov, Doctor of biological sciences, head of the laboratory of food chemistry of Federal Research Center of nutrition and biotechnology. Address: 109240, Moscow, 2/14 Ust`insky passage. ORCID: 0000-0002-3587-5347
Nana A. Anvarul, PhD, Senior researcher of medico-biological research laboratory of Scientific Research Institute of labour medicine named after academician N.F. Izmerov. Address: 105275, Moscow, 31 Budennogo Prospect.
Tel.: +7 (495) 365-59-41. E-mail: nanamt@mail.ru. ORCID 0000-0002-6093-947Х, SPIN-code: 2163-0860
Roman A. Khanferyan, MD, PhD, professor of the Medical Institute of Peoples’ Friendship University of Russia. Address: 117199, Moscow, 6 Miklukho-Maklaya Str. E-mail: khanfer1949@gmail.com. ORCID: 0000-0003-1178-7534


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