Clinical significance of non-cardial comboridity in patients with chronic heart failure


DOI: https://dx.doi.org/10.18565/therapy.2020.3.63-68

Antropova O.N., Osipova I.V., Markina I.L., Vladimirova V.S., Rusakova A.A.

Altai State Medical University of the Ministry of Healthcare of Russia, Barnaul
The aim of the study was to estimate the effect of non-cardial comorbid pathology at life quality, psychosocial factors, and adherence to therapy in patients with chronic heart failure (CHF).
Material and methods. 87 patients with I–III functional classCHF, average age 64,1±9,8 years, were examined by means of continuous sampling method. The Charlson comorbidity index (CI), quality of life according to the Kansas City Cardiomyopathy Questionnaire, cognitive function on the Montreal scale of cognitive functions, level of depression and anxiety on the Hospital scale of anxiety and depression were evaluated.
Results. 56,3% of patients had low comorbidity, and 43,7% had increased comorbidity. Patients with increased comorbidity were 28.7% more often (χ2=14,17; p=0,002) exposed to have a normal ejection fraction (EF). The number of patients with low treatment compliance was 18.2% higher among patients with high comorbidity (χ2=5,22; p=0,02). About half of the patients (55.2%) received less than 26 points on the cognitive function scale, which indicates a possible cognitive deficiency. Patients with high comorbidity were 23,3% more (χ2=14,17; p=0,002) exposed to subclinical depression.
Conclusion. About half of patients with heart failure have a high non-cardiac comorbidity. Patients with increased comorbidity (CI >3 points) are more likely to have normal left ventricular EF, low treatment compliance, subclinical depression, with no significant influence of CI at anxiety and quality of life.
Keywords: psychosocial risk factors, comorbidity, chronic heart failure
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About the Autors

Oksana N. Antropova, MD, professor, professor of the Department of faculty therapy and occupational diseases of Altai State Medical University of the Ministry of Healthcare of Russia. Address: 6565038, Barnaul, 40 Lenina Str.
Tel.: +7 (3852) 201-279. E-mail: antropovaon@mail.ru
Irina V. Osipova, MD, professor, head of the Department of faculty therapy and occupational diseases of Altai State Medical University of the Ministry of Healthcare of Russia. Address: 6565038, Barnaul, 40 Lenina Str. Tel.: +7 (3852) 201-279. E-mail: i.v.osipova@gmail.com
Irina L. Markina, PhD, associate professor, associate professor of faculty therapy and occupational diseases of Altai State Medical University of the Ministry of Healthcare of Russia. Address: 6565038, Barnaul, 40 Lenina Str.
Tel.: +7 (3852) 201-279. E-mail: ilmarkina@yandex.ru
V.S. Vladimirova, student of Altai State Medical University of the Ministry of Healthcare of Russia. Address: 6565038, Barnaul, 40 Lenina Str. Tel.: +7 (3852) 201-279
А.А. Rusakova, student of Altai State Medical University of the Ministry of Healthcare of Russia. Address: 6565038, Barnaul, 40 Lenina Str. Tel.: +7 (3852) 201-279


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