Pathogenesis of pre-malignant gastric lesions in patients with Marfan syndrome


DOI: https://dx.doi.org/10.18565/therapy.2020.6.71-81

Rudoy A.S., Uryvaev A.M.

Belarusian State Medical University, Minsk
The aim of the study was to identify the pathogenetic mechanisms of the development of precancerous changes in the gastric mucosa in Marfan syndrome (SM) and Marfan-like-pathology patients based on the molecular and morphological features of chronic gastritis.
Material and methods. Histological evaluation and immunohistochemical analysis of antibodies’ expression to transforming growth factor β (TGFβ) in the gastric mucosa in 51 patients with hereditary connective tissue disorders (dysplasias) aged 17 to 41 years were performed.
Results and conclusion. It was fixed, that hereditary disorders (dysplasias) of connective tissue (in case of SM and Marfan-like patbology) are an unfavorable background factor for the development of atrophic and fibrotic processes in the gastric mucosa in chronic gastritis. The key role of released TGFβ activity in the development of a special morphogenetic variant of early chronic atrophic multifocal gastritis at a young age has been proven.
Keywords: transforming growth factor β, Marfan-like conditions, atrophy of the gastric mucosa, hereditary connective tissue disorders, myofibroblasts, chronic gastritis, connective tissue dysplasia, Marfan syndrome
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About the Autors

Andrey S. Rudoy, MD, professor, head of the Department of military field therapy of Belarusian State Medical University, colonel of the medical service. Address: 220128, Belarus, Minsk, 26 Prospect Masherova Str. Tel.: +7 (375 17) 297-27-46. E-mail: andrewrudoj@gmail.com
Aleksey M. Uryvaev, PhD, associate professor of the Department of military field therapy of Belarusian State Medical University, lieutenant-colonel of the medical service. Address: 220128, Belarus, Minsk, 26 Prospect Masherova Str. Tel.: +7 (375 17) 297-27-46.


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