Atherosclerosis of the arteries of the lower extremities in a patient with type 2 diabetes mellitus


DOI: https://dx.doi.org/10.18565/therapy.2020.8.149-155

Kishkovich Yu.S., Demidova T.Yu.

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow
Diabetes mellitus is one of the risk factors for the development of atherosclerotic lesions of the vascular bed. In particular, the prevalence of diseases of the lower limb arteries among patients with diabetes mellitus reaches 29%. It is known that unsatisfactory glycemic control significantly worsens the prognosis in patients with atherosclerotic lesions of the arteries of the lower extremities, negatively affects the long-term results of arterial reconstruction in ischemia of the extremity. The control of the glycemic level is of particular importance in patients with critical ischemia of the lower extremities. Thus, a number of studies have demonstrated that satisfactory glycemic control is characterized by an improvement in outcomes after surgical interventions and reduces the risk of amputations in patients with atherosclerotic lesions of the arteries of the lower extremities. In this article, along with the general principles of diagnosis and therapy of diseases of the lower limb arteries with diabetes mellitus, a specific clinical case of managing a patient with this comorbid pathology is considered.

Literature



  1. Национальные рекомендации по диагностике и лечению заболеваний артерий нижних конечностей. Ассоциация сердечно-сосудистых хирургов России. Российское общество ангиологов и сосудистых хирургов. Российское общество хирургов. Российское кардиологическое общество. Российская ассоциация эндокринологов. 2019 г. Доступ: http://www.angiolsurgery.org/library/recommendations/2019/recommendations_LLA_2019.pdf (дата обращения – 01.11.2020). [National guidelines for the diagnosis and treatment of lower limb artery diseases. Association of Cardiovascular Surgeons of Russia. Russian Society of Angiologists and Vascular Surgeons. Russian Society of Surgeons. Russian Society of Cardiology. Russian Association of Endocrinologists. URL: http://www.angiolsurgery.org/library/recommendations/2019/recommendations_LLA_2019.pdf (date of access – 01.11.2020) (In Russ.)].

  2. Дедов И.И., Шестакова М.В., Майоров А.Ю. с соавт. Алгоритмы специализированной медицинской помощи больным сахарным диабетом / под ред. И.И. Дедова, М.В. Шестаковой, А.Ю. Майорова. 9-й выпуск. Сахарный диабет. 2019; S1–1: 1–144. [Dedov I.I., Shestakova M.V., Mayorov A.Y. et al. Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V., Mayorov A.Yu. 9th edition. Sakharniy diabet. 2019; S1–1: 1–144 (In Russ.)].

  3. Клинические рекомендации. Синдром диабетической стопы. Общественная организация Российская ассоциация эндокринологов (РАЭ). Московская ассоциация хирургов. 2015 г. Доступ: https://rae-org.ru/system/files/documents/pdf/kr525_sindrom_diabeticheskoy_stopy.pdf (дата обращения – 01.11.2020). [Clinical guidelines Diabetic foot syndrome. Russian Association of Endocrinologists. Moscow Association of Surgeons. 2015. URL: https://rae-org.ru/system/files/documents/pdf/kr525_sindrom_diabeticheskoy_stopy.pdf (date of access – 01.11.2020) (In Russ.)].

  4. Aboyans V., Ho E., Denenberg J.O. et al. The association between elevated ankle systolic pressures and peripheral occlusive arterial disease in diabetic and nondiabetic subjects. J Vasc Surg. 2008; 48(5): 1197–203. doi: 10.1016/j.jvs.2008.06.005.

  5. Удовиченко О.В., Грекова Н.М. Руководство для врачей. Диабетическая стопа. М.: Практическая медицина. 2010; 272 с. [Udovichenko O.V., Grekova N.M. A guide for doctors. Diabetic foot. M.: Practicheskaya meditsina. 2010. 2010; 272 p. (In Russ.)].

  6. Aboyans V., Criqui M.H., Abraham P. et al. American Heart Association Council on Peripheral Vascular Disease; Council on Epidemiology and Prevention; Council on Clinical Cardiology; Council on Cardiovascular Nursing; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia. Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association. Circulation. 2012; 126(24): 2890–909. doi: 10.1161/CIR.0b013e318276fbcb.

  7. Cosentino F., Grant P.J., Aboyans V. et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020; 41(2): 255–323. doi: 10.1093/eurheartj/ehz486.

  8. Aboyans V., Ricco J.-B., Bartelink M.-L.E.L. et al. 2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS). Rev Esp Cardiol (Engl Ed). 2018; 71(2): 111. doi: 10.1016/j.rec.2017.12.014.

  9. Selvarajah S., Black J.H. 3rd, Malas M.B. et al. Preoperative smoking is associated with early graft failure after infrainguinal bypass surgery. J Vasc Surg. 2014; 59(5): 1308–14. doi: 10.1016/j.jvs.2013.12.011.

  10. Hoel A.W. Nolan B.W., Goodney P.P. et al. Variation in smoking cessation after vascular operations. J Vasc Surg. 2013; 57(5): 1338–44; quiz 1344.e1–4. doi: 10.1016/j.jvs.2012.10.130.

  11. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348(9038): 1329–39. doi: 10.1016/s0140-6736(96)09457-3.

  12. Bhatt D.L., Fox K.A.A., Hacke W. et al. CHARISMA Investigators. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006; 354(16): 1706–17. doi: 10.1056/NEJMoa060989.

  13. Bedenis R., Lethaby A., Maxwell H. et al. Antiplatelet agents for preventing thrombosis after peripheral arterial bypass surgery. Cochrane Database Syst Rev. 2015; 2015(2): CD000535. doi: 10.1002/14651858.CD000535.pub3.

  14. Efficacy of oral anticoagulants compared with aspirin after infrainguinal bypass surgery (The Dutch Bypass Oral Anticoagulants or Aspirin Study): a randomised trial. Lancet. 2000; 355(9201): 346–51.


About the Autors


Yulia S. Kishkovich, assistant of the Department of endocrinology, faculty of general medicine of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityaninova Str. E-mail: maximovajuly22@gmail.com
Tatyana Yu. Demidova, MD, professor, head of the Department of endocrinology, faculty of general medicine of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 109263, Moscow, 4/1 Shkuleva Str. E-mail: t.y.demidova@gmail.com. ORCID: 0000-0001-6385-540X


Similar Articles


Бионика Медиа