Chronic brain ischemia as an interdisciplinary problem


DOI: https://dx.doi.org/10.18565/therapy.2021.5.149-156

Chukanova E.I., Chukanova A.S., Bagmanyan S.D.

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow
Abstract. The article reviews the issues of pathogenesis, clinic, diagnosis and treatment of chronic brain ischemia. Highlights of the development of «small vessel disease», endothelial dysfunction, processes of lipid peroxidation, apoptosis as well as neuroplasticity. The necessity of joint management of patients with chronic cerebral ischemia by neurologists and doctors of other specialties and the appointment of individualized pathogenetic therapy are noted.
Keywords: chronic brain ischemia, neuroplasticity, endothelial dysfunction, small vessel disease, apoptosis
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About the Autors

Elena I. Chukanova, MD, professor of the Department of of neurology, neurosurgery and medical genetics of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 177997, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (916) 781-56-23. E-mail: chukanova-elena@yandex.ru. ORCID: 0000-0002-32919615
Anna S. Chukanova, PhD, associate professor of the Department of of neurology, neurosurgery and medical genetics of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 177997, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (916) 215-45-66. E-mail: chukanova.anna@gmail.com. ORCID: 0000-0003-0940-782X
Sona D. Bagmanyan, senior laboratory assistant of the Department of of neurology, neurosurgery and medical genetics of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 177997, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (968) 628-96-57. E-mail: sona156@mail.ru. ORCID: 0000-0002-9221-5230


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