Levels of apoptosis indicators in patients with myocardial infarction on the background of chronic obstructive pulmonary disease depending on the time of development of myocardial ischemia


DOI: https://dx.doi.org/10.18565/therapy.2021.6.56-61

Naumov A.V., Prokofieva T.V., Polunina O.S., Saroyants L.V., Lipnitskaya E.A., Polunina E.A.

1) Astrakhan State Medical University of the Ministry of Healthcare of Russia; 2) Leprosy Research Institute of the Ministry of Healthcare of Russia, Astrakhan; 3) Regional Vascular Center of the State Medical Institution of Alexander-Mariinsky Regional Clinical Hospital, Astrakhan
Abstract. Objective: to identify the features of apoptosis in patients with chronic obstructive pulmonary disease complicated by acute myocardial infarction, depending on the duration of ischemia.
Material and methods. 65 patients with myocardial infarction were examined: 37 patients with chronic obstructive pulmonary disease and 28 patients without pulmonary pathology. Levels of annexin V, heat shock protein 70 (HSP70), and neopterin were determined.
Results and conclusion. It was found that the duration of ischemia is directly proportional to the level of apoptosis of circulating lymphocytes with the appearance of necrotic cells. Various intercellular interactions are involved in apoptotic cell death in myocardial infarction, which significantly contribute to myocardial damage. It can affect the subsequent processes of left ventricular remodeling.
Keywords: annexin, chronic obstructive pulmonary disease, myocardial infarction, heat shock proteins, interleukins, apoptosis
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About the Autors

Andrey V. Naumov, postgraduate student of the Department of internal medicine of the Faculty of pediatrics, Astrakhan State Medical University of the Ministry of Healthcare of Russia. Address: 414000, Astrakhan, 121 Bakinskaya Str. Tel.: +7 (8512) 52-41-43. E-mail: andrey.naumov.93@mail.ru. ORCID: 0000-0001-7874-7057
Tatiana V. Prokofieva, PhD, associate professor of the Department of internal medicine of the Faculty of pediatrics, Astrakhan State Medical University of the Ministry of Healthcare of Russia. Address: 414000, Astrakhan, 121 Bakinskaya Str. Tel.: +7 (927) 557-13-83. E-mail: prokofeva-73@inbox.ru. ORCID: 0000-0002-3260-2677
Olga S. Polunina, MD, professor, head of the Department of internal medicine of the Faculty of pediatrics, Astrakhan State Medical University of the Ministry of Healthcare of Russia. Address: 414000, Astrakhan, 121 Bakinskaya Str. Tel.: +7 (999) 600-13-03. E-mail: admed@yandex.ru. ORCID: 0000-0001-8299-6582
Lyudmila V. Saroyants, MD, head of Laboratory and Experimental Department, Leprosy Research Institute of the Ministry of Healthcare of Russia, Astrakhan. Address: 414057, Astrakhan, 3 Nikolaya Ostrovskogo Drive. Tel.: +7 (8512) 33-93-35. E-mail: luda_saroyants@mail.ru. ORCID: 0000-0002-4426-3860
Elena A. Lipnitskaya, PhD, associate professor of the Department of the Faculty therapy and occupational diseases with a course of postgraduate education, Astrakhan State Medical University of the Ministry of Healthcare of Russia, head of the Department of cardiology No. 2, Regional Vascular Center of the State Medical Institution of Alexander-Mariinsky Regional Clinical Hospital. Address: 414000, Astrakhan, 121 Bakinskaya Str. Tel.: +7 (8512) 52-41-43. E-mail: elenalipnitskaya@yandex ru. ORCID: 0000-0003-0398-647X
Ekaterina A. Polunina, MD, associate professor of the Department of internal medicine of the Faculty of pediatrics, Astrakhan State Medical University of the Ministry of Healthcare of Russia. Address: 414000, Astrakhan, 121 Bakinskaya Str. Tel.: +7 (908) 618-41-78. E-mail: gilti2@yandex.ru. ORCID: 0000-0002-3679-432X


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