Chronic obstructive pulmonary disease in combination with type 2 diabetes mellitus: features of the clinical picture


DOI: https://dx.doi.org/10.18565/therapy.2021.8.30-37

Sorokina L.N., Pavlova A.S., Mineev V.N., Trofimov V.I.

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia
Abstract. Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (DM2) are known to be comorbid diseases united by common pathogenetic pathways, among which systemic inflammation plays an important role.
The aim is to establish the features of the course of COPD in combination with type 2 diabetes according to the data of clinical and laboratory-instrumental examinations.
Material and methods. We examined 42 patients with COPD, 25 patients with a combination of COPD and DM2, 17 patients with DM2. All patients underwent a clinical and laboratory examination (Complete blood count and biochemical analysis), echocardiography, spirometry with a bronchodilator test.
Results. The group of patients with a combination of COPD and DM2 was characterized by high values of the body mass index, which is due to the contribution of the metabolic syndrome in this group. Such characteristics as the stage, clinical group, and phase of COPD in the groups with and without co-existing DM2 did not differ statistically significantly. The degree of respiratory failure was significantly higher in the group with a combination of COPD and DM2. In addition, the presence and severity of comorbidity of the cardiovascular system and the presence of cerebrovascular disease were significantly higher in the COPD group with co-existing DM2. The prevalence and degree of pulmonary hypertension in the groups with COPD did not differ. The results of laboratory tests, in general, are typical for these diseases.
Conclusion. Thus, it is confirmed that the course of COPD is worsened in the presence of comorbid conditions, in particular DM2, which should be taken into account in the management of patients with comorbid pathology, as well as in the development of approaches to the early diagnosis and treatment of these conditions.
Keywords: comorbid diseases, chronic obstructive pulmonary disease, type 2 diabetes mellitus
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About the Autors

Lada N. Sorokina, MD, professor, professor of the Department of hospital therapy with a course of allergology and immunology named after Academician Chernorutsky with the clinic, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: Address: 197022, St. Petersburg, Saint Petersburg, 6–8 L. Tolstogo Str. E-mail: lada_sorokina@mail.ru. ORCID: 0000-0001-6193-2774
Anastasia S. Pavlova, postgraduate student of the Department of hospital therapy with a course of allergology and immunology named after Academician Chernorutsky with the clinic, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: Address: 197022, St. Petersburg, Saint Petersburg, 6–8 L. Tolstogo Str. E-mail: pavast02@gmail.com. ORCID: 0000-0001-7934-0718
Valery N. Mineev, MD, professor, professor of the Department of hospital therapy with a course of allergology and immunology named after Academician Chernorutsky with the clinic, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: Address: 197022, St. Petersburg, Saint Petersburg, 6–8 L. Tolstogo Str. E-mail: vnmineev@mail.ru. ORCID: 0000-0003-0352-8137
Vasily I. Trofimov, MD, professor, head of the Department of hospital therapy with a course of allergology and immunology named after Academician Chernorutsky with the clinic, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: Address: 197022, St. Petersburg, Saint Petersburg, 6–8 L. Tolstogo Str. E-mail: trofvi@mail.ru


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