The influence of genetic features on the psychological status of patients who suffered from a myocardial infarction (literature review)


DOI: https://dx.doi.org/10.18565/therapy.2021.9.104-112

Golovenkin S.Е., Nikulina S.Yu., Bubnova М.G., Orlova Yu.V., Maksimov V.N.

1) Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russia; 2) National Medical Research Center of Therapy and Preventive Medicine of the Ministry of Healthcare of Russia, Moscow; 3) Research Institute of Therapy and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Abstract. Cardiac rehabilitation and secondary prevention of patients with acute myocardial infarction (MI) is an essential component in solving the common task of reducing mortality from cardiovascular causes. Unfortunately, not all patients after acute coronary events undergo a course of cardiac rehabilitation and then follow secondary prevention measures. An important place among the reasons for low compliance take the presence of anxiety and depression in this category of patients. The results of studies dedicated to the relationship between genetic peculiarities and psychological status of MI patients are discussed in the article. The role of a number of gene polymorphisms in the occurrence of anxiety and depression in such kind of patients is considered. The influence of age, comorbidity, duration of stress exposure and other factors influencing the psychological status of patients was revealed. An important section of the review is the discussion concerning candidate genes that can influence the interaction between MI and depression and may represent by themselves potential targets for therapeutic intervention.

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About the Autors


Sergey E. Golovenkin, PhD, associate professor of the Department of faculty therapy with the course of FPE, Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russia. Address: 660014, Krasnoyarsk, 12 Instrumentalnaya Str. Tel.: +7 (904) 890-35-42. E-mail: gse2008@mail.ru. ORCID: 0000-0003-0320-9312
Svetlana Yu. Nikulina, MD, professor, head of the Department of faculty therapy with a course of FPE, Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russia. Address: 660014, Krasnoyarsk, 12 Instrumentalnaya Str. Tel.: +7 (908) 212-53-79. E-mail: nicoulina@mail.ru. ORCID: 0000-0002-6968-7627
Marina G. Bubnova, MD, professor, head of the Department of rehabilitation and secondary prevention of cardiovascular diseases, National Medical Research Center of Therapy and Preventive Medicine of the Ministry of Healthcare of Russia. Address: 101990, Moscow, 10 Petroverigsky Lane. Tel.: +7 (903) 752-21-86. E-mail: mbubnova@gnicpm.ru. ORCID: 0000-0003-2250-5942
Yulia V. Orlova, clinical resident of the Department of faculty therapy with the course of FPE, Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russia. Address: 660014, Krasnoyarsk, 12 Instrumentalnaya Str. E-mail: juliann303@yandex.ru
Vladimir N. Maksimov, MD, professor, head of the laboratory of molecular genetic studies of therapeutic pathology, Research Institute of Therapy and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences. Address: 630089, Novosibirsk, 175/1 Borisa Bogatkova Str. Tel.: +7 (913) 903-44-89. E-mail: medik11@mail.ru. ORCID: 0000-0002-7165-4496


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