Psycho-emotional disorders in chronic heart failure patients


DOI: https://dx.doi.org/10.18565/therapy.2022.1.44-49

Shishkova V.N., Ustarbekova D.B., Shishkov V.A., Imamgayazova K.E., Kapustina L.A.

1) National Medical Research Center or Therapy and Preventive Medicine of the Ministry of Healthcare of Russia, Moscow; 2) A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia; 3) Kurchatov School, Moscow
Abstract. The purpose of the review is to present the actual data on the prevalence of anxiety and depressive disorders in patients with chronic heart failure (CHF); to consider the main pathogenetic mechanisms of the relationship in the development of psychoemotional disorders and cardiovascular diseases, with a focus at CHF. The article provides recommendations for performing depression and anxiety screening in patients with cardiovascular diseases; discussions of the prospects for managing such patients in the framework of interdisciplinary cooperation are also introduced.
Keywords: psycho-emotional disorders, affective disorders, depression, anxiety, chronic heart failure
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Literature


  1. Wittchen H.U., Jacobi F., Rehm J. et al. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011; 21(9): 655–79. https://dx.doi.org/10.1016/j.euroneuro.2011.07.018.

  2. Krupchanka D., Mlada K., Winkler P. et al. Mortality in people with mental disorders in the Czech Republic: A nationwide, register-based cohort study. Lancet Public Health. 2018; 3(6): e289–e295. https://dx.doi.org/10.1016/S2468-2667(18)30077-X.

  3. Scott K.M., de Jonge P., Alonso J. et al. Associations between DSM-IV mental disorders and subsequent heart disease onset: Beyond depression. Int J Cardiol. 2013; 168(6): 5293–99. https://dx.doi.org/10.1016/j.ijcard.2013.08.012.

  4. Jha M.K., Qamar A., Vaduganathan M. et al. Screening and Management of Depression in Patients with cardiovascular disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019; 73(14): 1827–45. https://dx.doi.org/10.1016/j.jacc.2019.01.041.

  5. Harter M., Baumeister H., Reuter K. et al. Increased 12-month prevalence rates of mental disorders in patients with chronic somatic diseases. Psychother Psychosom. 2007; 76(6): 354–60. https://dx.doi.org/10.1159/000107563

  6. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018; 392(10159): 1789–858. https://dx.doi.org/10.1016/S0140-6736(19)31047-5.

  7. Kivimaki M., Steptoe A. Effects of stress on the development and progression of cardiovascular disease. Nat Rev Cardiol. 2018; 15(4): 215–29. https://dx.doi.org/10.1038/nrcardio.2017.189

  8. Dar T., Radfar A., Abohashem S. et al. Psychosocial stress and cardiovascular disease. Curr Treat Options Cardiovasc Med. 2019; 21(5): 23. https://dx.doi.org/10.1007/s11936-019-0724-5

  9. Vaccarino V., Badimon L., Bremner J.D. et al. Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation. Eur Heart J. 2020; 41(17): 1687–96. https://dx.doi.org/10.1093/eurheartj/ehy913.

  10. Шишкова В.Н., Котова М.Б., Капустина Л.А., Имамгаязова К.Э. Вопросы патогенеза когнитивных и психоэмоциональных нарушений у пациентов с сердечно-сосудистыми и метаболическими заболеваниями. Терапия. 2021; 8: 158–63. [Shishkova V.N., Kotova M.B., Kapustina L.A., Imamgayazova K.E. Issues of pathogenesis of cognitive and psychoemotional disorders in patients with cardiovascular and metabolic diseases. Terapiya = Therapy. 2021; 8: 158–63 (In Russ.)]. https://dx.doi.org/10.18565/therapy.2021.8.158-163.

  11. Bauersachs J., de Boer R.A., Lindenfeld J.A. et al. The year in cardiovascular medicine 2021: Heart failure and cardiomyopathies. Eur Heart J. 2022; ehab88. https://dx.doi.org/10.1093/eurheartj/ehab887. Online ahead of print.

  12. Celano C.M., Villegas A.C., Albanese A.M., et al. Depression and anxiety in heart failure: A review. Harv Rev Psychiatry. 2018; 26(4): 175–84. https://dx.doi.org/10.1097/HRP.0000000000000162.

  13. Rutledge T., Reis V.A., Linke S.E. et al. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006; 48(8): 1527–37. https://dx.doi.org/10.1016/j.jacc.2006.06.055.

  14. Easton K., Coventry P., Lovell K. et al. Prevalence and measurement of anxiety in samples of patients with heart failure: Meta-analysis. J Cardiovasc Nurs. 2016; 31(4): 367–79. https://dx.doi.org/10.1097/JCN.0000000000000265.

  15. Daskalopoulou M., George J., Walters K. et al. Depression as a risk factor for the initial presentation of twelve cardiac, cerebrovascular, and peripheral arterial diseases: Data linkage study of 1.9 million women and men. PLoS One. 2016; 11(4): e0153838. https://dx.doi.org/10.1371/journal.pone.0153838.

  16. White J.R., Chang C.C., So-Armah K.A. et al. Depression and human immunodeficiency virus infection are risk factors for incident heart failure among veterans: Veterans Aging Cohort Study. Circulation. 2015; 132(17): 1630–38. https://dx.doi.org/10.1161/CIRCULATIONAHA.114.014443.

  17. Frasure-Smith N., Lesperance F., Habra M. et al. Elevated depression symptoms predict long-term cardiovascular mortality in patients with atrial fibrillation and heart failure. Circulation. 2009; 120(2): 134–40, 3p following 140. https://dx.doi.org/10.1161/CIRCULATIONAHA.109.851675.

  18. Roy S.S., Foraker R.E., Girton R.A. et al. Posttraumatic stress disorder and incident heart failure among a community-based sample of US veterans. Am J Public Health. 2015 105(4): 757–63. https://dx.doi.org/10.2105/AJPH.2014.302342.

  19. Friedmann E., Thomas S.A., Liu F. et al. Relationship of depression, anxiety, and social isolation to chronic heart failure outpatient mortality. Am Heart J. 2006; 152(5): 940.e1–8. https://dx.doi.org/10.1016/j.ahj.2006.05.009.

  20. Jiang W., Kuchibhatla M., Cuffe M.S. et al. Prognostic value of anxiety and depression in patients with chronic heart failure. Circulation. 2004; 110(22): 3452–56. https://dx.doi.org/10.1161/01.CIR.0000148138.25157.F9.

  21. Konstam V., Salem D., Pouleur H. et al. Baseline quality of life as a predictor of mortality and hospitalization in 5,025 patients with congestive heart failure. SOLVD Investigations. Studies of Left Ventricular Dysfunction Investigators. Am J Cardiol. 1996; 78(8): 890–95. https://dx.doi.org/10.1016/s0002-9149(96)00463-8.

  22. Pelle A.J., Pedersen S.S., Schiffer A.A. et al. Psychological distress and mortality in systolic heart failure. Circ Heart Fail. 2010; 3(2): 261–67. https://dx.doi.org/10.1161/CIRCHEARTFAILURE.109.871483.

  23. Celano C.M., Millstein R.A., Bedoya C.A. et al. Association between anxiety and mortality in patients with coronary artery disease: a meta-analysis. Am Heart J. 2015; 170(6): 1105–15. https://dx.doi.org/10.1016/j.ahj.2015.09.013.

  24. Ahmadi N., Hajsadeghi F., Mirshkarlo H.B. et al. Post-traumatic stress disorder, coronary atherosclerosis, and mortality. Am J Cardiol. 2011; 108(1): 29–33. https://dx.doi.org/10.1016/j.amjcard.2011.02.340.

  25. Alhurani A.S., Dekker R.L., Abed M.A. et al. The association of co-morbid symptoms of depression and anxiety with all-cause mortality and cardiac rehospitalization in patients with heart failure. Psychosomatics. 2015; 56(4): 371–80. https://dx.doi.org/10.1016/j.psym.2014.05.022.

  26. He J., Ogden L.G., Bazzano L.A. et al. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch Intern Med. 2001; 161(7): 996–1002. https://dx.doi.org/10.1001/archinte.161.7.996.

  27. Riegel B., Moser D.K., Anker S.D. et al. State of the science: promoting self-care in persons with heart failure: a scientific statement from the American Heart Association. Circulation. 2009; 120(12): 1141–63. https://dx.doi.org/10.1161/CIRCULATIONAHA.109.192628.

  28. Strine T.W., Mokdad A.H., Dube S.R. et al. The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults. Gen Hosp Psychiatry. 2008; 30(2): 127–37. https://dx.doi.org/10.1016/j.genhosppsych.2007.12.008.

  29. Westman P.C., Lipinski M.J., Luger D. et al. Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol. 2016; 67(17): 2050–60. https://dx.doi.org/10.1016/j.jacc.2016.01.073.

  30. Kell R., Haunstetter A. Dengler T.J., et al. Do cytokines enable risk stratification to be improved in NYHA functional class III patients? Comparison with other potential predictors of prognosis. Eur Heart J. 2002; 23(1): 70–78. https://dx.doi.org/10.1053/euhj.2001.2780.

  31. Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis. Psychosom Med. 2009; 71(2): 171–86. https://dx.doi.org/10.1097/PSY.0b013e3181907c1b.

  32. Young J.J., Bruno D., Pomara N. A review of the relationship between proinflammatory cytokines and major depressive disorder. J Affect Disord. 2014; 169: 15–20. https://dx.doi.org/10.1016/j.jad.2014.07.032.

  33. Kop W.J., Kuhl E.A., Barasch E. et al. Association between depressive symptoms and fibrosis markers: The Cardiovascular Health Study. Brain Behav Immun. 2010; 24(2): 229–35. https://dx.doi.org/10.1016/j.bbi.2009.09.017.

  34. Pitsavos C., Panagiotakos D.B., Papageorgiou C. et al. Anxiety in relation to inflammation and coagulation markers, among healthy adults: The ATTICA study. Atherosclerosis. 2006; 185(2): 320–26. https://dx.doi.org/10.1016/j.atherosclerosis.2005.06.001.

  35. Liu Y., Ho R.C., Mak A. The role of interleukin (IL)-17 in anxiety and depression of patients with rheumatoid arthritis. Int J Rheum Dis. 2012; 15(2): 183–87. https://dx.doi.org/10.1111/j.1756-185X.2011.01673.x.

  36. Kheirabadi G.R., Toghani F., Kousha M. et al. Is there any association of anxiety-depressive symptoms with vascular endothelial function or systemic inflammation? J Res Med Sci. 2013; 18(11): 979–83.

  37. Bankier B., Barajas J., Martinez-Rumayor A. et al. Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. Eur Heart J. 2008; 29(18): 2212–17. https://dx.doi.org/10.1093/eurheartj/ehn326.

  38. Passos I.C., Vasconcelos-Moreno M.P., Costa L.G. et al. Inflammatory markers in post-traumatic stress disorder: A systematic review, meta-analysis, and meta-regression. Lancet Psychiatry. 2015; 2(11): 1002–12. https://dx.doi.org/10.1016/S2215-0366(15)00309-0.

  39. Frenneaux M.P. Autonomic changes in patients with heart failure and in post-myocardial infarction patients. Heart. 2004; 90(11): 1248–55. https://dx.doi.org/10.1136/hrt.2003.026146.

  40. Kawachi I., Sparrow D., Vokonas P.S. et al. Decreased heart rate variability in men with phobic anxiety (data from the Normative Aging Study). Am J Cardiol. 1995; 75(14): 882–85. https://dx.doi.org/10.1016/s0002-9149(99)80680-8.

  41. Carney R.M., Freedland K.E. Depression and heart rate variability in patients with coronary heart disease. Cleve Clin J Med. 2009; 76 (Suppl 2): S13–17. https://dx.doi.org/10.3949/ccjm.76.s2.03.

  42. Fischer D., Rossa S., Landmesser U. et al. Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death. Eur Heart J. 2005; 26(1): 65–69. https://dx.doi.org/10.1093/eurheartj/ehi001.

  43. Mommersteeg P.M., Schoemaker R.G., Eisel U.L. et al. Nitric oxide dysregulation in patients with heart failure: the association of depressive symptoms with L arginine, asymmetric dimethylarginine, symmetric dimethylarginine, and isoprostane. Psychosom Med. 2015; 77(3): 292–302. https://dx.doi.org/10.1097/PSY.0000000000000162.

  44. Sherwood A., Hinderliter A.L., Watkins L.L. et al. Impaired endothelial function in coronary heart disease patients with depressive symptomatology. J Am Coll Cardiol. 2005; 46(4): 656–59. https://dx.doi.org/10.1016/j.jacc.2005.05.041.

  45. von Kanel R., Hepp U., Traber R. et al. Measures of endothelial dysfunction in plasma of patients with posttraumatic stress disorder. Psychiatry Res. 2008; 158(3): 363–73. https://dx.doi.org/10.1016/j.psychres.2006.12.003.

  46. Visseren F.L.J., Mach F., Smulders Y.M. et al. Developed by the task force for cardiovascular disease prevention in clinical practice with representatives of the European society of cardiology and 12 medical societies. Eur Heart J. 2021; 42(34): 3227–337. https://dx.doi.org/10.1093/eurheartj/ehab484.

  47. Kim J.M., Stewart R., Kang H.J. et al. Long-term cardiac outcomes of depression screening, diagnosis and treatment in patients with acute coronary syndrome: The DEPACS study. Psychol Med. 2021; 51(6): 964–74. https://dx.doi.org/10.1017/S003329171900388X.

  48. He W., Zhou Y., Ma J. et al. Effect of antidepressants on death in patients with heart failure: A systematic review and meta-analysis. Heart Fail Rev. 2020; 25(6): 919–26. https://dx.doi.org/10.1007/s10741-019-09850-w.


About the Autors

Veronika N. Shishkova, MD, head of the Department for the prevention of cognitive and psychoemotional disorders, National Medical Research Center or Therapy and Preventive Medicine of the Ministry of Healthcare of Russia. Address: 101990, Moscow, 10 Petroverigsky Lane. E-mail: veronika-1306@mail.ru
Diana B. Ustarbekova, postgraduate student at the Department for the prevention of cognitive and psychoemotional disorders, National Medical Research Center or Therapy and Preventive Medicine of the Ministry of Healthcare of Russia. Address: 101990, Moscow, 10 Petroverigsky Lane
Vsevolod A. Shishkov, student at the medical and biological class of the Faculty building, Kurchatov School, intern at the Department for the prevention of cognitive and psychoemotional disorders, National Medical Research Center or Therapy and Preventive Medicine of the Ministry of Healthcare of Russia. Address: 101990, Moscow, 10 Petroverigsky Lane
Kamilla E. Imamgayazova, junior researcher at the Department for the prevention of cognitive and psychoemotional disorders, National Medical Research Center or Therapy and Preventive Medicine of the Ministry of Healthcare of Russia. Address: 101990, Moscow, 10 Petroverigsky Lane
Lyudmila A. Kapustina, PhD, researcher at the Department for the prevention of cognitive and psychoemotional disorders, National Medical Research Center or Therapy and Preventive Medicine of the Ministry of Healthcare of Russia. Address: 101990, Moscow, 10 Petroverigsky Lane


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