Biomarkers in cardiology: microRNA and heart failure


DOI: https://dx.doi.org/10.18565/therapy.2022.1.60-70

Alieva A.M., Teplova N.V., Kislyakov V.A., Voronkova K.V., Shnakhova L.M., Valiev R.K., Rakhaev A.M., Elmurzaeva D.A., Malkarova D.S., Nikitin I.G.

1) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow; 2) I.M. Sechenov First Moscow State Medical University of the of the Ministry of Healthcare of Russia (Sechenovskiy University); 3) A.S. Loginov Moscow Clinical Scientific and Practical Center of the Moscow Department of Healthcare; 4) Kh.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia, Nalchik
Abstract. MicroRNAs (miRNAs) are small non-coding molecules of ribonucleic acid (RNA). MiRNAs regulate gene expression at the post-transcriptional level by binding to the 3’-untranslated regions of the target miRNA. MiRNAs have been identified as key regulators of complex biological processes associated with multiple cardiovascular pathologies, including left ventricular (LV) hypertrophy, coronary artery disease (CAD), heart failure (HF), hypertension, and arrhythmias. MiRNAs in the bloodstream have been investigated as novel biological markers, especially in the context of acute myocardial infarction (AMI) and HF. In our review, we presented data on the role of miRNA in HF.
Keywords: biological marker, ribonucleic acid, left ventricular ejection fraction, miRNA, polymerase chain reaction, gene, myocardial infarction, heart failure
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About the Autors

Amina M. Alieva, PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityaninova Str. E-mail: amisha_alieva@mail.ru. ORCID: 0000-0001-5416-8579. SPIN-code: 2749-6427
Natalia V. Teplova, MD, professor, head of the Department of clinical pharmacology of the Faculty of general medicine,
N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityaninova Str. ORCID: https://orcid.org/0000-0002-7181-4680
Vladimir A. Kislyakov, PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityaninova Str. E-mail: kvadoctor@mail.ru
Kira V. Voronkova, MD, professor of the Department of neurology of the Faculty of continuous professional education,
N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia; Central Clinical Hospital of RAS, Association of Epileptologists and Patients; Center for the Study of Falling Problems of the Falling Patient in Medicine. Address: 115280, Moscow, 1/1 Velozavodskaya Str., building 15. E-mail: kiravoronkova@yandex.ru. SPIN-code: 1636-7627. AuthorID: 668237. Индекс Хирша 9
Lidia M. Shnakhova, doctor at I.M. Sechenov First Moscow State Medical University of the of the Ministry of Healthcare of Russia (Sechenovskiy University). Address: 119435, Moscow, 4/1 Bol`shaya Pirogovskaya Str.
E-mail: shnakhova_l_m@staff.sechenov.ru
Ramiz K. Valiev, PhD, head of the Department of oncosurgery No. 2, A.S. Loginov Moscow Clinical Research Center of the Healthcare Department of Moscow. Address: 111123, Moscow, 86 Entuziastov Highway. E-mail: Radiosurgery@bk.ru.
ORCID: 0000-0003-1613-3716. SPIN-code: 2855-2867
Alik M. Rakhaev, MD, professor of the Department of children’s diseases, obstetrics and gynecology of the Faculty of general medicine, Kh.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia. Address: 360004, Nalchik, 173 Chernyshevskogo Str. Е-mail: alikrahaev@yandex.ru
Dzhannet A. Elmurzaeva, PhD, associate professor of the Department of microbiology, virology and immunology of the Faculty of medicine, Kh.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia. Address: 360004, Nalchik, 173 Chernyshevskogo Str. E-mail: jannet.elmurzaeva@yandex.ru.
ORCID: 0000-0002-5640-6638. SPIN-code: 7284-3749
Darina S. Malkarova, 6th year student of the Faculty of general medicine, Kh.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia. Address: 360004, Nalchik, 173 Chernyshevskogo Str.
Igor G. Nikitin, MD, professor, head of the Department of hospital therapy No. 2 of the Faculty of general medicine,
N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityaninova Str. E-mail: igor.nikitin.64@mail.ru. ORCID: 0000-0003-1699-0881


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