Rheumatoid factor in general medical practice. Part I – special features of laboratory diagnostics, detectability and clinical significance in rheumatological diseases


DOI: https://dx.doi.org/10.18565/therapy.2022.2.38-45

Lyalina V.V., Skripnichenko E.A., Binyakovsky R.V., Borisovskaya S.V., Dolgopolova V.S., Demuria T.T., Babayan D.V., Bocharov A.A., Polyakova Yu.V., Gulshin V.A., Modestova A.V., Nikitin I.G.

1) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow; 2) V.M. Buyanov City Clinical Hospital of the Healthcare Department of Moscow; 3) National Medical Research Center «Treatment and Rehabilitation Center» of the Ministry of Healthcare of Russia, Moscow
Abstract. An elevated level of rheumatoid factor (RF) is often considered to be an evidence of rheumatoid arthritis or other rheumatic disease. At the same time, RF is known to be a non-specific indicator. Current article discusses the significance of an increase of RF specifically in various rheumatic diseases. In addition, the peculiarities of the laboratory diagnostic process, which must be taken into account when interpreting the results, are discussed.
Keywords: undifferentiated arthritis, rheumatoid factor, seropositivity, articular syndrome, rheumatoid arthritis
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About the Autors

Vera V. Lyalina, PhD, associate professor of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: vera_lyalina@mail.ru.
ORCID: https://orcid.org/0000-0002-4262-4060
Elina A. Skripnichenko, postgraduate student of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: elkaskrip@gmail.com.
ORCID: https://orcid.org/0000-0001-6321-8419:
Rostislav V. Binyakovsky, clinical resident of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: binyakovskiy@gmail.com. ORCID: https://orcid.org/0000-0002-7371-0754
Svetlana V. Borisovskaya, PhD., associate professor of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: svabor@inbox.ru.
ORCID: https://orcid.org/0000-0002-9365-1472
Victoria S. Dolgopolova, clinical resident of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: dolgopolovavika@rambler.ru
Tamara T. Demuriya, clinical resident of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: tamunademuria078@gmail.com.
ORCID: https://orcid.org/0000-0002-0581-1043
Diana V. Babayan, clinical resident of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: dbabayan38@gmail.com.
ORCID: https://orcid.org/0000-0003-4158-0956
Anna A. Bocharova, clinical resident of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: bocharova.aan@gmail.com.
ORCID: https://orcid.org/0000-0002-1445-050X
Yulia V. Polyakova, therapist of the admission Department of V.M. Buyanov City Clinical Hospital of the Healthcare Department of Moscow. Address: 115516, Moscow, 26 Bakuskaya Str. E-mail: kirichenkoyly@yandex.ru.
ORCID: https://orcid.org/0000-0002-0184-9378
Vadim A. Gulshin, therapist of the admission Department of V.M. Buyanov City Clinical Hospital of the Healthcare Department of Moscow. Address: 115516, Moscow, 26 Bakuskaya Str. E-mail: vadimgulshin@gmail.com.
ORCID: https://orcid.org/0000-0002-2855-5804
Anna V. Modestova, PhD, associate professor of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: a.modestowa@yandex.ru. ORCID: https://orcid.org/0000-0002-7980-5500
Igor G. Nikitin, MD, professor, head of the Department of hospital therapy No. 2 of the Faculty of general medicine,
N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Director of the National Medical Research Center «Treatment and rehabilitation center» of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: igor.nikitin.64@mail.ru. ORCID: https://orcid.org/0000-0003-1699-0881


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