Русский
The effect of asymptomatic hyperuricemia on the frequency and structure of comorbidity patients with rheumatoid arthritis
DOI: https://dx.doi.org/10.18565/therapy.2022.6.27-33
Mazurov V.I., Gaydukova I.Z., Tsinzerling A.Yu., Bashkinov R.A., Inamova O.V., Petrova M.S.
1) North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg; 2) Clinical Rheumatology Hospital No. 25, Saint Petersburg
The aim of the study was to study the effect of HU on the frequency and structure of CP in patients with RA.
Material and methods. The data of 262 patients with RA and HU and 262 with RA without HU (comparison group) included in the City Register from January 2000 to April 2020 were analyzed. Information was entered on demographic characteristics (gender, age), diagnosis, presence and duration of HU, presence of CP and CP therapy. HU was understood as a recorded increase in the level of uric acid (UA) in the blood serum >360 mmol/l by ≥1 time.
Results. The data of 524 patients (440 women and 84 men, the average age 60,0±13,6 years) with RA for the period from January 2000 to April 2020 were analyzed. Patients with HU were divided into two subgroups: the first – the level of UA less than 500 mmol/l, the second – the level of UA more than 500 mmol/l. Patients with HU had a high incidence of arterial hypertension (84,21, 80,91 and 51,14 %), atrial fibrillation/flutter (9,21, 8,18 and 4,19 %), chronic heart failure of functional class I-III (23,68, 20 and 8,78 %), hypercholesterolemia (62,5, 67,27 and 34,4 %), prediabetes (18,42, 17,27 and 4,96 %), type 2 diabetes mellitus (25, 25,45 and 11,45 %), obesity of 1–3 degrees (32,89, 22,73 and 4,96 %), cholelithiasis (24,34, 21,82 and 11,07 %), non-alcoholic fatty liver disease (23,03, 23,64 and 6,49 %), urolithiasis (14,47, 16,36 and 8,78 %), kidney cysts (17,76, 20 and 9,16%), chronic kidney disease of stages 1–4 (58,55, 57,27 and 35,5 %) in comparison with patients without HU (p <0,05).
Conclusions. 1) HU in patients with RA is associated with a higher frequency of cardiovascular diseases, metabolic disorders and chronic kidney disease. 2) Arterial hypertension (84%), hypercholesterolemia (62%) and chronic kidney disease (58%) were most often detected.
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About the Autors
Vadim I. Mazurov, Dr. med. habil., professor, academician of RAS, chief scientific consultant, director of the Research Institute of Rheumatology, head of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia, head of the Center for autoimmune diseases, Clinical Rheumatology Hospital No. 25, Honored Scientist of the Russian Federation. Address: 191014, Saint Petersburg, 41 Kirochnaya Str. E-mail: maz.nwgmu@yandex.ru. ORCID: https://orcid.org/0000-0002-0797-2051. SPIN-code: 6823-5482
Inna Z. Gaydukova, Dr. med. habil., deputy director of the Research Institute of Rheumatology, professor of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191014, Saint Petersburg, 41 Kirochnaya Str. E-mail: ubp1976@list.ru; ORCID: https://orcid.org/0000-0003-3500-7256. SPIN-код: 3083-7996
Alexandra Yu. Tsinzerling, rheumatologist at the Clinical Rheumatology Hospital No. 25, senior laboratory assistant/applicant of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191014, Saint Petersburg, 41 Kirochnaya Str. E-mail: aleksa.fonturenko@mail.ru.
ORCID: https://orcid.org/0000-0003-4860-0518
Roman A. Bashkinov, postgraduate student of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia, rheumatologist at the Clinical Rheumatology Hospital No. 25. Address: 191014, Saint Petersburg, 41 Kirochnaya Str. E-mail: bashkinov-roman@mail.ru. ORCID: https://orcid.org/0000-0001-9344-1304
Oksana V. Inamova, PhD in Medicine, chief physician of the Clinical Rheumatology Hospital No. 25, deputy director of the Research Institute of Rheumatology, assistant at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191014, Saint Petersburg, 41 Kirochnaya Str. E-mail: b25@zdrav.spb.ru. ORCID: https://orcid.org/0000-0001-9126-3639
Marianna S. Petrova, PhD in Medicine, deputy chief physician of the Clinical Rheumatology Hospital No. 25, head of Saint Petersburg City Clinical Center for Gout, associate professor of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191014, Saint Petersburg, 41 Kirochnaya Str. E-mail: podagra@bk.ru. ORCIDID: https://orcid.org/0000-0001-5261-6614
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