Hyperbaric oxygenation in the complex for long-COVID-infection rehabilitation measures


DOI: https://dx.doi.org/10.18565/therapy.2022.5.81-85

Malyavin A.G., Kostina N.E., Efremova O.Yu., Levina O.A., Evseev A.K., Shabanov A.K.

1) A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia; 2) Voronezh Regional Clinical Hospital No. 1; 3) N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Department of Healthcare of Moscow
Abstract. Tactics of intensive care for patients with a new coronavirus infection caused by the SARS-CoV-2 virus implies an integrated approach both at the stage of the early clinical course of the disease and, importantly, during the rehabilitation period. One of the effective methods to reduce the risk of developing an ongoing infection (long-COVID) and post-COVID syndrome is hyperbaric oxygen (HBO) therapy. The inclusion of HBO in the complex therapy of patients with COVID-19 on the early stages of the disease helps the rapid elimination of hypoxia, the improvement of biochemical and immunological parameters, the normalization of the body’s redox homeostasis and apoptosis processes. Due to its multifactorial action (normalization of microcirculation in affected organs, restoration of immunity, pronounced bactericidal effect, restoration of metabolism), HBO is an effective tool at the stages of early rehabilitation of patients with COVID-19.
Keywords: long-COVID infection, hyperbaric oxygen therapy, hypoxia, rehabilitation
Read entire article

Literature

1. Цинзерлинг В.А., Вашукова М.А., Васильева М.В. с соавт. Вопросы патоморфогенеза новой коронавирусной инфекции (COVID-19). Журнал инфектологии. 2020; 2: 5–11. [Zinserling V.A., Vashukova M.A., Vasilyeva M.V. et al. Issues of pathology of a new coronavirus infection COVID-19. Zhurnal infektologii = Journal Infectology. 2020; 2: 5–11 (In Russ.)].https://dx.doi.org/10.22625/2072-6732-2020-12-2-5-11. EDN: YTQMKJ.


2. Леонов А.Н. Элементы теории гипербарической оксигенации. В кн.: Метаболические механизмы гипербарической оксигенации. Воронеж: ВГМИ. 1980: с. 161–168. [Leonov A.N. Elements of the theory of hyperbaric oxygenation. In the book: Metabolic mechanisms of hyperbaric oxygenation. Voronezh: Voronezh State Medical Institute. 1980: pp. 161–168 (In Russ.)].


3. Самойлов А.С., Удалов Ю.Д., Шеянов М.В. с соавт. Опыт применения гипербарической оксигенотерапии с использованием портативных барокамер для лечения пациентов с новой коронавирусной инфекцией COVID-19. Биомедицина. 2020; 2: 39–46. [Samoilov A.S., Udalov Yu.D., Sheyanov M.V. et al. Experience in applying hyperbaric oxygen therapy using portable pressure chambers for the treatment of patients with the novel coronavirus infection COVID-19. Biomeditsina = Journal Biomed. 2020; 2: 39–46 (In Russ.)]. https://dx.doi.org/10.33647/2074-5982-16-2-39-46. EDN: CPQCPE.


4. Левина О.А., Евсеев А.К., Шабанов А.К. с соавт. Безопасность применения гипербарической оксигенации при лечении COVID- 19. Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2020; 3: 314–320. [Levina O.A., Еvseev A.K., Shabanov A.K. et al. The safety of hyperbaric oxygen therapy in the treatment of Covid-19. Zhurnal im. N.V. Sklifosovskogo «Neotlozhnaya meditsinskaya pomoshch’» = Russian Sklifosovsky Journal «Emergency Medical Care» (In Russ.)].https://dx.doi.org/10.23934/2223-9022-2020-3-314-320. EDN: XHRRMA.


5. Струк Ю.В., Костина Н.Э., Якушева О.А., Ефремова О.Ю., Савилов П.Н. Гипербарическая оксигенация в интенсивной терапии пациентов с коронавирусной инфекцией COVID-19: учебно-методическое пособие. Воронеж: ВГМУ. 2022; 91 с. [Struk Yu.V., Kostina N.E., Yakusheva O.A., Efremova O.Yu., Savilov P.N. Hyperbaric oxygen therapy in the intensive care of patients with coronavirus infection COVID-19: a teaching aid. Voronezh: Voronezh State Medical University. 2022; 91 pp. (In Russ.)].


6. Временные методические рекомендации «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)». Версия 13 (14.10.2021). Минздрав России. Доступ: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/058/211/original/BMP-13.pdf (дата обращения – 12.05.2022). [Interim guidelines «Prevention, diagnosis and treatment of novel coronavirus infection (COVID-19)». Version 13 (10/14/2021). Ministry of Healthcare of Russia.URL: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/058/211/original/BMP-13.pdf (date of access – 12.05.2022).


7. Петриков С.С., Евсеев А.К., Левина О.А. с соавт. Гипербарическая оксигенация в терапии пациентов с COVID-19. Общая реаниматология. 2020; 6: 4–18. [Petrikov S.S., Evseev A.K., Levina O.A. et al. Hyperbaric oxygen therapy in patients with COVID-19. Obschaya reanimatologiya = General Reanimatology. 2020; 6: 4–18 (In Russ.)].https://dx.doi.org/10.15360/1813-9779-2020-6-4-18. EDN: IYSPJE.


8. Zhong X., Tao X., Tang Y., Chen R. The outcomes of hyperbaric oxygen therapy to retrieve hypoxemia of severe novel coronavirus pneumonia: First case report. Chin J Naut Med Hyperbaric Med. 2020, 27(0): E001–E001.https://dx.doi.org/10.3760/cma.j.issn.1009-6906.2020.0001.e.


9. Guo D., Pan S., Wang M.M., Guo Y. Hyperbaric oxygen therapy may be effective to improve hypoxemia in patients with severe COVID-2019 pneumonia: Two case reports. Undersea Hyperb Med. 2020; 47(2): 181–87. https://dx.doi.org/10.22462/04.06.2020.2.


10. Thibodeaux K., Speyrer Z., Raza A. et al. Hyperbaric oxygen therapy in preventing mechanical ventilation in COVID-19 patients: A retrospective case series. J Wound Care. 2020; 29(Sup5a): S4–S8. https://dx.doi.org/10.12968/jowc.2020.29.Sup5a.S4.


11. Gorenstein S.A., Castellano M.L., Slone E.S. et al. Hyperbaric oxygen therapy for COVID-19 patients with respiratory distress: Treated cases versus propensity-matched controls. Undersea Hyperb Med. 2020; 47(3): 405–13. https://dx.doi.org/10.22462/01.03.2020.1.


12. Левина О.А., Евсеев А.К., Шабанов А.К. с соавт. Гипербарическая оксигенация в лечении пациентов с новой коронавирусной инфекцией COVID-19. В кн.: Диагностика и интенсивная терапия больных COVID-19. Руководство для врачей (под ред. С.С. Петрикова). М.: ГЭОТАР-Медиа. 2021; с. 393–410. [Levina O.A., Evseev A.K., Shabanov A.K. et al. Hyperbaric oxygen therapy in the treatment of patients with novel coronavirus infection COVID-19. In the book: Diagnosis and intensive care of patients with COVID-19. Guide for doctors (ed. by S.S. Petrikov). Moscow: GEOTAR-Media. 2021; pp. 393–410 (In Russ.)]. ISBN: 978-5-9704-6340-6.


13. Cannellotto M., Duarte M., Keller G. et al. Hyperbaric oxygen as an adjuvant treatment for patients with COVID-19 severe hypoxaemia: A randomised controlled trial. Emerg Med J. 2022; 39(2): 88–93. https://dx.doi.org/10.1136/emermed-2021-211253


14. Liang Y., Fan N., Zhong X., Fan W. A case report of a patient with severe type of coronavirus disease 2019 (COVID-19) treated by hyperbaric oxygen: CT dynamic changes. Iran J Radiol. 2020; 17(4): e104475. https://dx.doi.org/10.5812/iranjradiol.104475.


15. Екимов В.В. Влияние гипербарической оксигенации на структурно-функциональное состояние тромбоцитов при синдроме диссеминированного внутрисосудистого свёртывания крови. В кн.: Механизмы гипербарической оксигенации (под ред. А.Н. Леонова). Воронеж: ВГМИ. 1986; с. 123–125. [Ekimov V.V. The impact of hyperbaric oxygenation on the structural and functional state of platelets in the syndrome of disseminated intravascular coagulation. In the book: Mechanisms of hyperbaric oxygenation (ed. by A.N. Leonov). Voronezh: Voronezh State Medical Institute. 1986: pp. 123–125 (In Russ.)].


16. Бышевский А.Ш., Терсенев О.А., Мухачева М.А. О роли циркулирующего в крови фактора III в регуляции ее агрегатного состояния. Тезисы Всесоюзной конференции «Актуальные проблемы гемостаза в клинической практике». М. 1987; с. 141. [Byshevsky A.Sh., Tersenev O.A., Mukhacheva M.A. On the role of factor III circulating in the blood in the regulation of its aggregate state. Abstracts of the All-Union Conference «Actual problems of hemostasis in clinical practice». Moscow. 1987; p. 141 (In Russ.)].


17. Resanovic I., Gluvic Z., Zaric B. et al. Early effects of hyperbaric oxygen on inducible nitric oxide synthase activity/expression in lymphocytes of type 1 diabetes patients: A prospective pilot study. Int J Endocrinol. 2019; 2019: 2328505.https://dx.doi.org/10.1155/2019/2328505.


18. Дьячкова С.Я. Иммунобиологические эффекты гипероксии. Воронеж: ИП Рагузин А.В. 2020; 159 с. [Dyachkova S.Ya. Immunobiological effects of hyperoxia. Voronezh: IE Raguzin A.V. 2020; 159 pp. (In Russ.)]. ISBN: 978-5-9908543-1-4.


19. Кошелев П.И., Бельских В.М., Паршиков Е.А., Паршина Ю.С. Влияние гипербарической оксигенации на гистоморфологические изменения легочной паренхимы при абсцессе легкого в эксперименте. В кн.: Морфологические аспекты гипербарической оксигенации (под ред. Э.Г. Быкова, А.Н. Леонова). Воронеж: Транспорт. 1980; с. 86–90. [Koshelev P.I., Belskikh V.M., Parshikov E.A., Parshina Yu.S. The effect of hyperbaric oxygenation on histomorphological changes in the lung parenchyma in lung abscess in the experiment. In the book: Morphological aspects of hyperbaric oxygenation (ed. by E.G. Bykov, A.N. Leonov). Voronezh: Transport. 1980; pp. 86–90 (In Russ.)].


20. Буравцов В.И. Эффективность ГБО в комплексном лечении больных с инфекционно-деструктивными заболеваниями легких. Вестник хирургии имени Грекова. 1989; 131: 37–41. [Buravtsov V.I. Efficiency of hyperbaric oxygenation in the complex treatment of patients with infectious and destructive lung diseases. Vestnik khirurgii imeni Grekova = Bulletin of Surgery named after Grekov. 1989; 131: 37–41 (In Russ.)].


About the Autors

Andrey G. Malyavin, Dr. med. habil., professor, professor of the Department of phthisiology and pulmonology of the Faculty of general medicine, A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 107150, Moscow, 39/2 Losinoostrovskaya Str. E-mail: maliavin@mail.ru.
ORCID: https://orcid.org/0000-0002-6128-5914. Scopus Author ID: 6701876872
Natalya E. Kostina, PhD in Medicine, head of the Department of pulmonology, Voronezh Regional Clinical Hospital No.1, chief freelance pulmonologist of the Voronezh region. Address: 394066, Voronezh, 151 Moskovsky Avenue. E-mail: nata166k@yahoo.com. ORCID: https://orcid.org/0000-0002-5128-5005
Olga Yu. Efremova, PhD in Medicine, head of the Department of hyperbaric oxygenation, Voronezh Regional Clinical Hospital No.1. Address: 394066, Voronezh, 151 Moskovsky Avenue
Olga A. Levina, PhD in Medicine, leading researcher at the Clinic of Emergency Neurosurgery, N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Department of Healthcare of Moscow. Address: 129090, Moscow, 3 Bol`shaya Sukharevskaya Sq. E-mail: levina_olga@bk.ru. ORCID: https://orcid.org/0000-0002-4811-0845
Anatoly K. Evseev, Dr. med. habil., leading researcher at the Department of general resuscitation, N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Department of Healthcare of Moscow. Address: 129090, Moscow, 3 Bol`shaya Sukharevskaya Sq. E-mail: anatolevseev@gmail.com.
ORCID: https://orcid.org/0000-0002-0832-3272
Aslan K. Shabanov, Dr. med. habil., senior researcher at the Department of general resuscitation, N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Department of Healthcare of Moscow. Address: 129090, Moscow, 3 Bol`shaya Sukharevskaya Sq. E-mail: aslan_s@mail.ru. ORCID: https://orcid.org/0000-0002-3417-2682


Similar Articles

Back to Content

Бионика Медиа