Русский
Features of myocardial pathology in patients with extra-axial manifestations of ankylosing spondylitis
DOI: https://dx.doi.org/10.18565/therapy.2022.7.27-32
Feyskhanova L.I., Abdrakipov R.Z., Vivolanets A.A., Akhmedieva D.V., Abdulganieva D.I.
1) Kazan State Medical University of the Ministry of Healthcare of Russia; 2) Republican Clinical Hospital of the Ministry of Healthcare of the Republic of Tatarstan, Kazan
Purpose of the study: to determine the relationship between extra-axial manifestations and cardiac pathology in patients with AS.
Material and methods. A total of 153 patients with AS participated in the study. The patients were divided into 2 groups: 1st – with extraaxial manifestations, 78 people; 2nd gr – without them, 75 people. Patients underwent blood tests to determine the levels of CRP, two-dimensional transthoracic echocardiography, vectorcardiography.
Results. Results of the 1st group: E/A level of transthoracic flow, P loop area were significantly higher; relative thickness of the left ventricular wall inversely correlated with QRS loop area (r=- 0,36, p=0,02); EchoCG and vectorcardiography parameters had no relation with ASDAS-ESR, BASDAI, BASFI indices. Results of the 2nd group: relative wall thickness had a weak direct relationship with ASDAS-ESR index (r=0,29, p=0,03) and an inverse relationship with maximal vector modulus (r=-0,33, p=0,04).
Conclusion. Thus, in AS with extra-axial manifestations, there is an increase in atrial electrical activity accompanied by diastolic dysfunction of the right ventricle.
Literature
1. Эрдес Ш.Ф. Анкилозирующий спондилит. Серия «Тактика врача-специалиста». М.: ГЭОТАР-Медиа. 2020; 184 с. Erdes Sh.F. Ankylosing spondylitis. Series «Tactics of a specialist doctor». Moscow: GEOTAR-Media. 2020; 184 p. (In Russ.)].https://dx.doi.org/10.33029/9704-5732-0-ANK-2020-1-184. ISBN: 978-5-9704-5732-0.
2. Aggarwal R., Malaviya A.N. Clinical characteristics of patients with ankylosing spondylitis in India. Clin Rheumatol. 2009; 28(10): 1199–205. https://dx.doi.org/10.1007/s10067-009-1227-7.
3. Гайдукова И.З., Ребров А.П. Риск появления ишемической болезни сердца у больных анкилозирующим спондилитом (болезнью Бехтерева) и псориатическим артритом по результатам десятилетнего проспективного наблюдения (исследование прогресс). Клиницист. 2016; 10(3): 26–31. [Gaidukova I.Z., Rebrov A.P. The risk of coronary artery disease development in patients with ankylosing spondylitis (Bechterew’s disease) and psoriatic arthritis: a 10-year prospective follow-up study. Klinitsist = The Clinician. 2016; 10(3): 26–31 (In Russ.)]. https://dx.doi.org/10.17650/1818-8338-2016-10-3-26-31. EDN: XKOIOZ.
4. Vinker Shuster M., Gendelman O., Tiosano S. et al. Ischemic heart disease and ankylosing spondylitis - assessing the role of inflammation. Clin Rheumatol. 2018; 37(4): 1053–58. https://dx.doi.org/10.1007/s10067-018-4037-y.
5. Forsblad-d’Elia H., Wallberg H., Klingberg E. et al. Cardiac conduction system abnormalities in ankylosing spondylitis: A cross-sectional study. BMC Musculoskelet Disord. 2013; 14: 237. https://dx.doi.org/10.1186/1471-2474-14-237.
6. van der Linden S., Valkenburg H., Cats A. Evaluation of diagnostic criteria for ankylos-ing spondylitis: A proposal to modification of the New York criteria. Arthritis Rheum. 1984; 27(4): 361–68. https://dx.doi.org/10.1002/art.1780270401.
7. Бурдина Е.Н., Ховаева Я.Б., Головской Б.В., Бурдин В.В. Подход к оценке состояния миокарда по данным векторкардиографии в модифицированном варианте и эхокардиографии. Ультразвуковая и функциональная диагностика. 2008; 4: 48–52. [Burdina E.N., Khovaeva Ya.B., Golovskoy B.V., Burdin V.V. The approach to assessment of myocardium condition using the results of modified variant of vectorcardiography and echocardiography. Ul’trazvukovaya i funktsional’naya diagnostika = Journal of Ultrasound and Functional Diagnostics. 2008; 4: 48–52 (In Russ.)]. EDN: JWZUPN.
8. Фролов С.В., Строев В.М., Горбунов А.В., Трофимов В.А. Методы и приборы функциональной диагностики. Учебное пособие. Тамбов: Издательство Тамбовского государственного технического университета. 2008; с. 39–44. [Frolov S.V., Stroev V.M., Gorbunov А.V., Trofimov V.А. Methods and devices of functional diagnostics. Tutorial. Tambov: Publishing house of the Tambov State Technical University. 2008; pp. 39–44 (In Russ.)]. ISBN: 978-5-8265-0762-9.
9. Nazarinia M.A., Ghaffarpasand F., Heiran H.R., Habibagahi Z. Pattern of ankylosing spondylitis in an Iranian population of 98 patients. Mod Rheumatol. 2009; 19(3): 309–15. https://dx.doi.org/10.1007/s10165-009-0153-5.
10. Бурдина Е.Н. Особенности ремоделирования и электрической активности миокарда левого желудочка при артериальной гипертензии: автореферат диссертации на соискание ученой степени кандидата медицинских наук: 14.00.06. Пермь: ГОУВПО «Пермская государственная медицинская академия» Минздрава России. 2008; 129 с. Доступ: http://www.dslib.net/kardiologia/osobennosti-remodelirovanija-i-jelektricheskoj-aktivnosti-miokarda-levogo-zheludochka.html (дата обращения – 01.08.2022). [Burdina E.N. Features of remodeling and electrical activity of the myocardium of the left ventricle in arterial hypertension: abstract of the dissertation for the degree of candidate of medical sciences: 14.00.06. Perm: Perm State Medical Academy of the Ministry of Healthcare of Russia. 2008; 129 pp. URL: http://www.dslib.net/kardiologia/osobennosti-remodelirovanija-i-jelektricheskoj-aktivnosti-miokarda-levogo-zheludochka.html (date of access – 01.08.2022) (In Russ.)].
11. Годзенко А.А., Бочкова А.Г., Румянцева О.А. с соавт. Взаимосвязь между поражением сердца и другими клиническими проявлениями анкилозирующего спондилита. Научно-практическая ревматология. 2010; 48(5): 32–36. [Godzenko A.A., Bochkova A.G., Rumyantseva O.A. et al. Association between cardiac lesion and other clinical manifestations of ankylosing spondylitis. Nauchno-prakticheskaya revmatologiya = Scientific and Practical Rheumatology. 2010; 48(5): 32–36 (In Russ.)]. EDN: NDIFFF.
12. Chahal N.S., Lim T.K., Jain P. et al. Normative reference values for the tissue Doppler imaging parameters of left ventricular function: A population-based study. Eur J Echocardiogr. 2010; 11(1): 51–56. https://dx.doi.org/10.1093/ejechocard/jep164.
13. Шахнович П.Г., Захарова А.И., Черкашин Д.В. с соавт. Диастолическая дисфункция миокарда: эхокардиографический феномен или вид сердечной недостаточности? Вестник Российской военно-медицинской академии. 2015; 3: 54–57. [Shakhnovich P.G., Zakharova A.I., Cherkashin D.V. et al. Diastolic myocardium dysfunction: echocardiographic phenomenon or type of heart failure? Vestnik Rossiyskoy voyenno-meditsinskoy akademii = Herald of the Russian Military Medical Academy. 2015; 3: 54–57 (In Russ.)]. EDN: VSTUSX.
About the Autors
Lucia I. Feyskhanova, PhD in Medicine, associate professor of the Department of hospital therapy, Kazan State Medical University of the Ministry of Healthcare of Russia. Address: 420012, Kazan, 49 Butlerova Str. E-mail: ljuts@rambler.ru. ORCID: https://orcid.org/0000-0001-7830-5283
Rifkat Z. Abdrakipov, rheumatologist, head of the Department of rheumatology, Republican Clinical Hospital of the Ministry of Healthcare of the Republic of Tatarstan. Address: 420064 Kazan, 138 Orenburgsky tract. E-mail: hosptherapy@mail.ru. ORCID: https://orcid.org/0000-0003-1140-3238
Anastasia A. Vivolanets, 6th year student of the Faculty of general medicine, Kazan State Medical University of the Ministry of Healthcare of Russia. Address: 420012, Kazan, 49 Butlerova Str. E-mail: vivnastia@gmail.com. ORCID: https://orcid.org/0000-0001-6793-7939
Diana V. Akhmedieva, 6th year student of the Faculty of general medicine, Kazan State Medical University of the Ministry of Healthcare of Russia. Address: 420012, Kazan, 49 Butlerova Str. E-mail: adhimaa@yandex.ru. ORCID: https://orcid.org/0000-0002-7666-0326
Diana I. Abdulganieva, Dr. med. habil., professor, head of the Department of hospital therapy, Kazan State Medical University of the Ministry of Healthcare of Russia. Address: 420012, Kazan, 49 Butlerova Str. E-mail: diana_s@mail.ru. ORCID: https://orcid.org/0000-0001-7069-2725
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