Русский
Study of macrophage infiltration of various organs’ tissues in case of COVID-19 coronavirus infection
DOI: https://dx.doi.org/10.18565/therapy.2022.10.7-12
Vishnyakov D.S., Kabirov I.R., Enikeeva K.I., Kalimullina L.I., Sadretdinova L.D., Tyurin A.V., Pavlov V.N., Kzhyskowska Yu.G.
1) Bashkir State Medical University of the Ministry of Healthcare of Russia, Ufa; 2) University of Heidelberg, Germany; 3) National Research Tomsk State University
The aim of the study was to determine the presence of macrophage infiltration in various organs and tissues in patients with COVID-19.
Material and methods. A complex pathoanatomical study of sectional material obtained after autopsies of 23 deceased patients with the main diagnosis of COVID-19 was carried out.
Results. Multiple aberrant aggregations of obese CD68 positive macrophages were found, with lesions predominantly observed in the parenchyma of the lungs and kidneys.
Conclusion. CD68-positive macrophages were detected in all organs studied in COVID-19 patients, with different intensity and localization of infiltration, which may indicate a single mechanism of pathogenesis in lesions of various organs in patients with this disease.
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About the Autors
Dmitry S. Vishnyakov, assistant of the Department of pathological anatomy, Bashkir State Medical University of the Ministry of Healthcare of Russia. Address: 450071, Ufa, 3 Lesnoy Drive. E-mail: nomadsoul84@gmail.com. ORCID: https://orcid.org/0000-0001-7339-0589
Ildar R. Kabirov, PhD in Medicine, acting vice-rector for innovative work and digital transformation, associate professor of the Department of urology with the course of FVE, Bashkir State Medical University of the Ministry of Healthcare of Russia. Address: 450071, Ufa, 3 Lesnoy Drive. E-mail: ildarkabirov@gmail.ru.
ORCID: https://orcid.org/0000-0002-5496-0766
Kadriya I. Enikeeva, assistant of the Department of pharmacology with a course of clinical pharmacology, Bashkir State Medical University of the Ministry of Healthcare of Russia Address: 450071, Ufa, 3 Lesnoy Drive. E-mail: kalya1996@mail.ru. ORCID: https://orcid.org/0000-0002-5995-2124
Liliya I. Kalimullina, junior researcher at central scientific research laboratory, Bashkir State Medical University of the Ministry of Healthcare of Russia. Address: 450071, Ufa, 3 Lesnoy Drive. E-mail: lilia.kalim@mail.ru. ORCID: https://orcid.org/0000-0001-5355-9623
Lidiya D. Sadretdinova, assistant at the Department of internal medicine, Bashkir State Medical University of the Ministry of Healthcare of Russia. Address: 450071, Ufa, 3 Lesnoy Drive. E-mail: shuraleyka1@mail.ru. ORCID: https://orcid.org/0000-0002-7161-3977
Anton V. Tyurin, PhD in Medicine, professor, head of the Department of internal diseases, Bashkir State Medical University of the Ministry of Healthcare of Russia. Address: 450071, Ufa, 3 Lesnoy Drive. E-mail: anton.bgmu@gmail.com. ORCID: https://orcid.org/0000-0002-0841-3024
Valentin N. Pavlov, Dr. med. habil., professor, academician of the Russian Academy of Sciences, head of the Department of urology with the course of FVE, Bashkir State Medical University of the Ministry of Healthcare of Russia. Address: 450071, Ufa, 3 Lesnoy Drive. E-mail: pavlov@bashgmu.ru.
ORCID: https://orcid.org/0000-0003-2125-4897
Julia G. Kzhyshkovska, Doctor of Biological Sciences, professor, head of the Department of innate immunity and immunological tolerance, Institute of immunology and transfusion medicine, Faculty of Medicine, Mannheim, University of Heidelberg, head of the laboratory of translational cellular and molecular biomedicine, National Research Tomsk State University. Address: German Red Cross Blood Service of Baden-Wurttemberg – Hessen, Mannheim 13-17 D-68167 Ludolf Krehl Strasse Str. E-mail: julia.kzhyshkowska@medma.uni-heidelberg.de. ORCID: https://orcid.org/0000-0003-0898-3075
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